RESUMEN

B-cell activating factor (BAFF) is a B-cell growth factor. We measured its serum levels and correlated them with parameters of disease activity, as serum levels of tumor necrosis factor-α and lactate dehydrogenase, bone marrow microvascular density and proliferating cell nuclear antigen expression, in 50 myeloma patients, in 22 of them in plateau phase and in 20 controls. All of them were higher in patients and in advanced disease while reduced in plateau phase. BAFF correlated with all the above markers. Higher BAFF levels predicted a shorter survival, suggesting an important prognostic marker and a possible therapeutic target in myeloma.

Asunto(s)

Factor Activador de Células B/sangre , Mieloma Múltiple/diagnóstico , Neovascularización Patológica/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Factor Activador de Células B/análisis , Biomarcadores de Tumor/análisis , Biomarcadores de Tumor/sangre , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mieloma Múltiple/sangre , Mieloma Múltiple/irrigación sanguínea , Mieloma Múltiple/mortalidad , Neovascularización Patológica/sangre , Pronóstico , Análisis de Supervivencia