RESUMEN

Elk-1 belongs to the Ternary Complex Factor (TCF) subfamily of the ETS (from E26 viral oncogene) domain superfamily of transcription factors, and has been known as a regulator of mitogen-induced immediate early gene transcription upon Mitogen Activated Protein Kinase (MAPK) activation. Elk-1 has been previously shown to interact with neuronal microtubules, and here we show that P-S383-Elk-1, in addition to co-localizing with motor proteins kinesin, Eg5 and Mitotik Kinesin-Like Protein (MKLP) at the mitotic spindles, it physically interacts with dynein in a serum induction-dependent but Ser383 phosphorylation-independent manner.

Asunto(s)

Dineínas/metabolismo , Fosfoserina/metabolismo , Suero/metabolismo , Proteína Elk-1 con Dominio ets/metabolismo , Animales , Línea Celular Tumoral , ADN/metabolismo , Humanos , Fosforilación , Unión Proteica , Transporte de Proteínas , Ratas , Tubulina (Proteína)/metabolismo