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Patients with chronic obstructive pulmonary disease (COPD) may have a limited level of physical activity in daily life (PADL) and health-related quality of life (HRQOL). The interrelationships of these variables should be measure by cluster analysis to characterize this population and enable rehabilitation programs to target each patient profile identified. This study investigates different phenotypes in COPD according to PADL and HRQOL. A cross-sectional study with cluster analysis was done, in which 76 people with COPD were submitted to measurements to characterize the sample on first day, followed by used of physical activity monitor, which was worn for 7 days. After 7 days, the six-minute walk test (6MWT) and HRQOL questionnaires were applied (St. George's Respiratory Questionnaire). The main results: three phenotypes were identified (A, B and C), with phenotype A who exhibited an inactive physical activity level and HRQOL scores above the value deemed satisfactory, phenotype B those with active physical activity level and poor HRQOL scores, and phenotype C subjects with inactive physical activity level and HRQOL scores but the value is close to cutoff point. To conclude, three phenotypes were found, with one indicating disproportionality between PADL and HRQOL.

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OBJECTIVE: To determine the accuracy of incremental Shuttle Walking Test (ISWT) in detecting exercise-induced bronchospasm (EIB) in adults with asthma and to verify whether there is an association of the drop in FEV1 between ISWT and cardiopulmonary exercise testing with constant-load CPET-CL. METHODS: In this cross-sectional study 32 individuals with asthma performed two ISWTs, an incremental cardiopulmonary exercise test (CPET-I) and a constant-load cardiopulmonary exercise test (CPET-CL) with na interval of 48 h between tests. Spirometric measurements were obtained 5, 10, 15, 20 and 30 min after exercise; an FEV1 decline > 10% was considered EIB. RESULTS: Fifteen individuals had EIB in both tests [χ2 = 9.41; κ = 0.46 p < 0.002 (95% CI: 0.201-0.708)], with moderate agreement. There was a significant correlation between the greatest variation in the drop in FEV1 between the ISWT and the CPET-CL (r = 0.48; p < 0.01). There was a significant difference for ventilation maintenance time above 40% of Maximum Voluntary Ventilation between the groups of positive EIB (p = 0.001) and negative EIB (p = 0.001) and for ventilatory demand (positive EIB group) (p = 0.008) between ISWT vs CPET-CL. Moreover, assuming CPET-CL as the criterion test, ISWT presented a sensitivity of 62.5% and specificity was 100%. CONCLUSION: ISWT showed moderate accuracy in detecting EIB in adults with asthma and was able to show similar metabolic and ventilatory demand presented in CPET-CL.

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Physical inactivity and peripheral muscle dysfunction are considered two of the main contributors to hospitalizations due to exacerbation and, above all, predictors of mortality for these requirements in patients with COPD. Therefore, longitudinal studies are needed to determine the impact of exacerbations during hospitalization on these two factors, especially after three months of hospital discharge. The objectives of the present study were to assess the level of physical activity in daily life (PADL) and isometric muscle strength of the quadriceps in patients hospitalized for exacerbation of COPD and to verify changes after 3 months of hospital discharge. This is a longitudinal observational study that assessed the PADL level with an accelerometer, after 24 h of the hospitalization and the beginning of the drug treatment and assessed the quadriceps muscle strength with a manual dynamometer, after 72 h of hospitalization, in 32 patients with COPD (66 ± 7.61 years), in addition to repeating both assessments with 30 days of hospital discharge and after 3 months of follow-up. Cognition, dyspnea, general health, physical performance and lung function were assessed to characterize the sample. As main results, there was increase in active time (344 ± 260 - 447 ± 199 min; p = 0.04) and number of steps (4.241 ± 374 - 6.216 ± 400 steps; p = 0.02) after three months. In addition, inactive time showed significant reduction 30 days after hospital discharge (1.151 ± 249 - 1.065 ± 198 min; p = 0.02). The level of physical activity showed significant improvement due to the increase in active time and number of steps after three months of hospital discharge and to the reduction of inactive time 30 days after hospital discharge.

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BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) present pulmonary and extrapulmonary impairments. The strategies used to mitigate these impairments are pulmonary rehabilitation programs (PRP). However, there is limited access to PRP in specialized centers and the study of low-cost home rehabilitation programs had non-individualized prescription, which might have led to insignificant positive effects. So, it is important to develop new low-cost protocols that involve individualized prescription, as well as physiotherapist supervision. This study describes an accessible, low-cost, and individualized pulmonary rehabilitation protocol and compare its results when performed with or without a weekly physiotherapist-supervised session on patients with COPD. METHODS: This is a descriptive protocol of a clinical trial, randomized, single-blinded, and type of framework is superiority conducted at the Spirometry and Respiratory Physical Therapy Laboratory of the Federal University of São Carlos (UFSCar). The trial is registered in the Brazilian Clinical Trials Registry (ReBec) URL: http://www.ensaiosclinicos.gov.br/rg/RBR-533hht/ with Register Number UTN code U1111-1220-8245. The sample size is 50 patients and is calculated using the results of a pilot study. DISCUSSION-POTENTIAL IMPACT AND SIGNIFICANCE OF THE STUDY: It is expected that the low-cost and new supervised rehabilitation program complemented with home exercises will present positive results, especially on exercise capacity, which will make available a more accessible and effective PRP for patients with COPD. TRIAL REGISTRATION: ClinicalTrials.gov U1111-1220-8245 . Registered on September 20, 2018.

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OBJECTIVE: This study aimed to evaluate the intrarater and interrater reliability of isometric quadriceps strength (IQS) using a portable dynamometer in individuals with chronic obstructive pulmonary disease (COPD) and to verify their tolerance to the protocol. METHODS: A cross-sectional reliability study was conducted with 50 individuals with stable COPD (34 men and 16 women; mean age = 70 years [SD = 8]). The main outcome measure was obtained using a portable dynamometer (Microfet 2) to assess IQS. Two masked raters performed 2 assessments in the dominant lower limb on 2 nonconsecutive days. The intraclass correlation coefficient (ICC) was used to verify the intrarater and interrater reliability and was considered excellent when >0.90, with a 5% significance level. RESULTS: Rater 1 and 2 intrarater reliability was as follows: ICC = 0.96 (95% CI = 0.94 to 0.98) and ICC = 0.97 (95% CI = 0.95 to 0.98), respectively. The interrater reliability was as follows: ICC = 0.96 (95% CI = 0.93 to 0.98). The minimum detectable difference was 4 to 5 peak isometric strength, in mean, for intrarater and interrater reliability. Not all patients presented relevant changes in physiological responses, dyspnea, and lower limb fatigue. CONCLUSION: There was an excellent intrarater and interrater reliability for IQS, and the participants tolerated the protocol. IMPACT: This tool can be used to assess quadriceps strength in clinical practice in patients with COPD.

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INTRODUCTION: COPD Assessment Test (CAT) is a questionnaire defined as one of the main options in the assessment of the impact of Chronic Obstructive Pulmonary Disease on patients' life, according to the Global Initiative on Obstructive Lung Diseases. However, the Consensus-based Standards for the Selection of Health Measurement Instruments-COSMIN 2018 has recently determined a correlation coefficient greater than 0.70 and an optimal sample size must have a hundred subjects, hence, validity of the Brazilian version of this instrument is still not yet proven. OBJECTIVE: To verify the validity of the Brazilian version of the Questionnaire CAT in patients with Chronic Obstructive Pulmonary Disease, comparing it to the Saint George's Respiratory Questionnaire (SGRQ) and correlate it with other outcomes. MATERIALS AND METHODS: Observational transversal study with 101 COPD diagnosed subjects who underwent anthropometric data collection, life habits, CAT and SGRQ questionnaires, modified Medical Research Council (mMRC) dyspnoea scale. Spirometry, six-minute walking test (6MWT) and body mass index, Dyspnoea and exercise capacity (BODE). Each evaluative measure was compared to the total CAT score. The validity was considered for a significant Pearson correlation coefficient (r) greater than 0.7. RESULTS: It was observed a strong correlation between the total CAT score and the total SGRQ score (r = 0.703; P < 0.001), as well as moderate correlation with mMRC (r = 0.518; P < 0.001). SGRQ Symptoms (r = 0.627; P < 0.001). SGRQ Activity (r = 0.636; P < 0.001) and SGRQ Impact (r = 0.655; P < 0.001). There were similar correlations between CAT and other variables (6MWT, mMRC and BODE) and SGRQ and the same variables. CONCLUSION: The CAT questionnaire is a valid, reliable and easy-to-use instrument for assessing symptoms and can record the impact of COPD on the patient's quality of life.

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OBJECTIVE: To assess the validity and reliability of the 6-min step test (6MST) in individuals with coronary artery disease (CAD). METHODS: In a randomized and crossover design, 35 patients with CAD (65.8 ± 9.6 years), referred by a physician of a cardiology ambulatory, performed two 6MSTs and two 6-min walk tests (6MWTs) in order to assess reliability in patients with arterial coronary disease. The order of performance of the tests was established by a draw. RESULTS: 6MST test-retest reliability was excellent (intraclass correlation coefficient = 0.967; 95% CI: 0.766, 0.989; p < .05). There was an increase of 7.9 ± 8.2 steps from the first to the second 6MST, with a technical error of measurement = 8.0; p < .001. The correlations between distance walked in the 6MWT and number of steps in the 6MST in the first and second tests were 0.6 and 0.7 (p < .001), respectively. CONCLUSION: The 6MST is a reliable test to measure functional capacity in individuals with CAD. The test is valid when using 6MWT as the gold standard. There is an 88% chance of a subject classified in a given tertile by the 6MWT being in the same tertile in the 6MST.

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BACKGROUND: Respiratory secretions impact negatively on palliative patients. Unfortunately, a gold standard therapy is not yet available. The purpose of this study was to identify which interventions are in use to control respiratory secretions in patients with chronic disease with a poor prognosis and verify their effects on outcomes relevant for palliative care patients. METHODS: A systematic review of the literature with narrative summary was conducted. We searched eight electronic databases in April (6th), 2016. Citation-tracking and reference list searches were conducted. We included randomized controlled trials, crossover trials, observational and qualitative studies regarding interventions for respiratory secretion management in adult patients with chronic diseases that met inclusion criteria indicating short prognosis. RESULTS: Six randomized controlled trials, 11 observational studies, ten crossover trials and one qualitative study were found. Interventions included mechanical insufflation-exsufflation (MIE), expiratory muscle training, manually-assisted cough, tracheotomy, chest physiotherapy, suctioning, air stacking, electrical stimulation of abdominal muscles, nebulized saline, positive expiratory pressure masks, percussive ventilation, high frequency chest wall oscillations. The interventions with most promising benefits to patients in palliative care were manually-assisted cough and mechanical insufflation-exsufflation to promote expectoration and percussive ventilation to improve mucous clearance. CONCLUSION: Therapies, such as manually assisted cough, mechanical insufflation-exsufflation and percussive ventilation, which aim to deal with respiratory secretion, were the most promising treatment for use in palliative care for specific diseases. Nevertheless, the evidence still needs to improve in order to identify which treatment is the best.

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Objective To analyze if there is influence of body weight, body mass index (BMI), body composition, dyspnoea, grip strength and tolerance to exertion in the occurrence of exacerbation during a 12-month follow up of patients with COPD who underwent a physical training program. Material and methods Sixty three patients were distributed in two groups, (Exacerbation Group — EG, n = 29; Non-Exacerbated Group — NEG, n = 34). The Mann Whitney test was used for the comparison between groups, the Friedman test (posthoc Dunn) to compare the assessments and the logistic regression analysis, with a significance level of p < 0.05. Results There is a significant difference between the groups in age and walked distance (WD) in the sixminute walk test (6MWT). The WD was reduced in 6th, 9th and 12th month revaluation compared to baseline and 3 months for the EG. Logistic regression analysis showed a significant interaction between the lean body mass and the WD, BMI with the lean body mass and the BMI with the WD, this and the isolated dyspnoea, and lean body mass with body weight. Conclusion Involving several variables along the follow up of patients with COPD in physical therapy programs is important, since it may prevent or reduce the chance of the occurrence of exacerbations. In addition, older patients with less tolerance to physical activity had a higher number of episodes of exacerbation, even when participating in a physiotherapy program associated to exercise training. .

Objetivos Analisar se há influência do peso corporal, índice de massa corpórea (IMC), composição corporal, dispneia, força de preensão palmar (FPP) e tolerância ao esforço na ocorrência de exacerbação ao longo de 12 meses de acompanhamento de pacientes com DPOC submetidos a um programa de treinamento físico que desenvolveram ou não a exacerbação. Métodos Sessenta e três pacientes foram distribuídos em dois grupos (Grupo Exacerbação — GE, n = 29; Grupo Não Exacerbação — GNE, n= 34). O teste Mann-Whitney foi utilizado para a comparação entre os grupos, teste de Friedman (post-hoc e Dunn) para comparação das avaliações e a análise de regressão logística, com nível de significância p < 0,05. Resultados Há diferença significativa entre os grupos quanto à idade e distância percorrida (DP) no teste de caminhada de seis minutos (TC6). A DP apresentou-se reduzida no 6º, no 9º e no 12º mês de reavaliação comparados a avaliação e ao 3º mês para o GE. Na análise de regressão logística observou-se interação significativa entre a MM e a DP, IMC com a MM, bem como do IMC com a DP, desta e da dispneia isoladas e da MM com o peso corporal. Conclusão Conclui-se a importância de envolver diversas variáveis ao longo do acompanhamento de pacientes com DPOC em programas fisioterapêuticos na tentativa de prevenir a ocorrência de exacerbações ou reduzir sua chance de ocorrência. Além disso, pacientes mais idosos e com menor tolerância à atividade física tiveram maior número de episódios de exacerbação, mesmos estando inseridos em um programa fisioterapêutico de treinamento físico. .

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Introdução Força muscular de membros inferiores (MMII) diminuída associa-se à limitação da capacidade funcional; entretanto, existem poucas evidências sobre a repercussão direta da fraqueza muscular periférica sobre tarefas de equilíbrio, bem como com o prognóstico de mortalidade nos pacientes com doença pulmonar obstrutiva crônica (DPOC). Objetivos Verificar se há relação da força isométrica de MMII com Índice BODE e equilíbrio funcional de pacientes com DPOC em reabilitação pulmonar (RP), além de investigar se esses pacientes apresentam fraqueza muscular, e se tal característica é capaz de influenciar nessas variáveis. Materiais e métodos Trata-se de um estudo transversal, onde avaliou-se 24 pacientes (idade > 50 anos) de ambos os gêneros, com DPOC moderada a muito grave (VEF1 = 44 (31 - 62,8)% previsto), por meio de:modified Medical Research Council (mMRC), Teste de Caminhada de 6 minutos (TC6), Índice BODE, TesteTimed “Up and Go” (TUG), Escala de Equilíbrio de Berg (EEB),Dynamic Gait Index (DGI) e Teste de Força Isométrica de Extensores de Joelho (ExtJ) e Abdutores de Quadril (AbdQ). Resultados Na amostra estudada, 54% dos pacientes apresentaram fraqueza muscular em ExtJ, com correlações moderadas da força de MMII com Índice BODE (AbdQ = -0,58) e mMRC (ExtJ = -0,48; AbdQ = -0,49). Foram encontradas diferenças para DPTC6 e mMRC quando a força dos ExtJ foi classificada em normal ou diminuída. Conclusão A força de AbdQ está associada ao prognóstico de mortalidade e a força de MMII está associada à sintomatologia em pacientes com DPOC em RP. Embora a força de MMII apresente impacto negativo na capacidade funcional e na dispneia, os pacientes desse estudo mantiveram preservado o equilíbrio e mobilidade funcional.

Introduction Decreased lower limb’s isometric strength (LLIS) is associated with impaired functional capacity, however there is not sufficient evidence showing direct impact of peripheral muscle weakness on balance tasks, as well as on prognosis of mortality in patients with chronic obstructive pulmonary disease (COPD). Objectives To assess the correlation of the LLIS with BODE index and functional balance in patients with COPD in pulmonary rehabilitation (PR) and to investigate if these patients present muscle weakness, being able to influence the balance and the prognosis of mortality. Materials and methods This was a cross-sectional study which evaluated 24 patients (age > 50 years) of either genders, with moderate to very severe obstruction (FEV1 = 44 (31 - 62,8)% predicted). The following assessments were conducted: modified Medical Research Council (mMRC), Six-minute Walk Test (6MWT), BODE index, Timed Test "Up and Go" (TUG), Berg Balance Scale (BBS), Dynamic Gait Index (DGI), Muscle Strength Test in Knee Extensors (KExt) and Hip Abductors (HAbd). Results In this sample, 54% of patients had muscle weakness in ExtJ, with significant correlations of LLIS with BODE index (HAbd = -0.58) and mMRC (KExt = -0.48; HAbd = -0.49). There were differences for 6MWT and mMRC among patients with normal or decreased knee extensor strength. Conclusions The HAbd strength is associated with the prognosis of mortality and LLIS with dyspnea in patients with COPD, even under PR program. Although LLIS presented negative impact on functional capacity and dyspnea, these patients tend to keep preserved balance and functional mobility.

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INTRODUÇÃO: Os testes caminhada de seis minutos (TC6) e degrau de seis minutos (TD6) são meios de avaliação da capacidade funcional. No entanto, pouco se sabe sobre sua reprodutibilidade em adultos jovens. OBJETIVO: Avaliar a reprodutibilidade relativa e absoluta tanto intra quanto inter-avaliadores do TC6 e TD6 em indivíduos adultos jovens. MÉTODOS: Foram avaliados 33 indivíduos adultos jovens aparentemente saudáveis por meio da espirometria; e realizados os testes TC6 e TD6. Três (T1, T2 e T3) TC6 e TD6 foram feitos em cada indivíduo, sendo o último de cada teste realizado por um avaliador diferente. Para a análise intra-avaliadores foram comparados os desempenhos do T1 e T2 enquanto que a análise inter-avaliadores foi feita pela comparação dos desempenhos do T3 com: T1; T2; e escolha do melhor dos primeiros dois testes. Foi calculado o coeficiente de correlação intra-classe (CCI) como medida da reprodutibilidade relativa; o erro padrão de medida; a diferença mínima detectável; traçados gráficos de Bland-Altman e teste ANOVA para analisar a reprodutibilidade absoluta. RESULTADOS: Observaram-se, nos dois testes funcionais, intra e inter-avaliadores, valores excelentes de reprodutibilidade relativa (CCI>0,75) e a reprodutibilidade absoluta mostrou alto erro. CONCLUSÃO: O TD6 e o TC6 apresentaram reprodutibilidade intra e inter-avaliadores excelente para a população adulto jovem, mas altos valores de erro. .

INTRODUCTION: Six Minute Walk Test (6MWT) and Six Minute Step Test (6MST) are tests to evaluate functional capacity. However, reproducibility of these tests is still not well known in young adults. OBJECTIVE: To evaluate intra and inter-rater relative and absolute reproducibility of 6MWT and 6MST in young adults. METHODS: Thirty-three apparently health young adults were evaluated through spirometry, 6MWT and 6MST. Three (T1, T2 and T3) of each 6MWT and 6MST were carried out on each individual, the latter (T3) by a different evaluator. Intra-rater analysis was performed comparing the performance of T1 and T2, while the inter-rater analysis was executed using the comparisons of T3 with T1, T2 and the best result of the first two. Intra-class correlation coefficient (ICC) was calculated as a measure of relative reproducibility; the standard error of measurement, minimal detectable change, Bland-Altman plots and repeated measures ANOVA were used to verify absolute reproducibility. RESULTS: Excellent values of relative reproducibility (ICC>0.75) were observed in both 6MWT and 6MST, yet high error values were found in absolute reproducibility analysis. CONCLUSION: 6MWT and 6MST present excellent intra and inter-rater relative reproducibility, but high error values. .

INTRODUCCIÓN: Los tests de caminata de seis minutos (TC6) y escalón de seis minutos (TD6) son medios de evaluación de la capacidad funcional. Mientras tanto, poco se sabe sobre su reproductibilidad en adultos jóvenes. OBJETIVO: Evaluar la reproductibilidad relativa y absoluta tanto intra como inter-evaluadores del TC6 y TD6 en individuos adultos jóvenes. MÉTODOS: Fueron evaluados 33 individuos adultos jóvenes aparentemente saludables por medio de espirometría; y realizados los tests TC6 y TD6. Tres (T1, T2 y T3) TC6 y TD6 fueron hechos en cada individuo, siendo el último de cada test realizado por un evaluador diferente. Para el análisis intra-evaluadores fueron comparados los desempeños del T1 y T2 mientras que el análisis inter-evaluadores fue hecho por la comparación de los desempeños del T3 con: T1; T2; y selección del mejor de los primeros dos tests. Fue calculado el coeficiente de correlación intra-clase (CCI) como medida de la reproductibilidad relativa; el Error Estándar de Medida; la diferencia mínima detectable; trazados gráficos de Bland-Altman y test ANOVA para analizar la reproductibilidad absoluta. RESULTADOS: Se observaron, en los dos tests funcionales, intra e inter-evaluadores, valores excelentes de reproductibilidad relativa (CCI>0,75) y la reproductibilidad absoluta mostró alto error. CONCLUSIÓN: El TD6 y el TC6 presentaron reproductibilidad intra e inter-evaluadores excelente para la población adulto joven, pero altos valores de error. .