RESUMEN

Complexities of lethal challenge models have prompted the investigation of immunogenicity assays as potency tests of anthrax vaccines. An ELISA and a lethal toxin neutralization assay (TNA) were used to measure antibody response to Protective Antigen (PA) in mice immunized once with either a commercial or a recombinant PA (rPA) vaccine formulated in-house. Even though ELISA and TNA results showed correlation, ELISA results may not be able to accurately predict TNA results in this single immunization model.

Asunto(s)

Vacunas contra el Carbunco/inmunología , Carbunco/prevención & control , Antígenos Bacterianos/inmunología , Toxinas Bacterianas/inmunología , Animales , Carbunco/inmunología , Anticuerpos Antibacterianos/inmunología , Ensayo de Inmunoadsorción Enzimática , Femenino , Ratones , Pruebas de Neutralización , Proteínas Recombinantes/inmunología , Vacunas Sintéticas/inmunología