RESUMEN
La Leiomiomatosis peritoneal diseminada (LPD) es una entidad muy rara caracterizada por múltiples nódulos benignos del músculo liso que aparecen en mujeres en edad reproductiva. Su degeneración maligna sólo ha sido reportada en la literatutra mundial en 5 casos (1). el presente reporte, constituye el sexto caso con degeneración maligna histológicamente comprobada. nuestro caso representa el único con trasformación maligna en una paciente menopáusica que recibía tratamiento hormonal sustitutivo continuo y con todos los estudios preoperatorios
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Histerectomía , Leiomiomatosis/clasificación , Miometrio , Ovario/anomalías , Útero/anomalíasRESUMEN
Dopaminergic receptors have been involved in the cardiovascular and renin-angiotensin systems (RAS). We have recently reported that bromocriptine is an effective antihypertensive drug by stimulating DA(2) dopaminergic receptors. However, the nature of the dopaminergic receptors in RAS has not been established. Ten outpatients with essential hypertension were treated at the Vargas Hospital with bromocriptine (BR) (11.25 mg day(minus sign1)), a DA(2) dopaminergic agonist, for a 2-week period, after which an oral dose of 30 mg day(minus sign1) of domperidone (DO), a peripheric DA(2) dopaminergic antagonist, was added for 2 additional weeks. The active period was preceeded by a 2-week placebo period. Bromocriptine decreased blood pressure (BP) significantly by 19/9 mm Hg (systolic/diastolic BP). Bromocriptine did not cause heart rate (HR) changes. Bromocriptine decreased plasma aldosterone (ALD) without altering plasma renin activity (PRA). Domperidone partially blocked bromocriptine-induced antihypertensive submaximal treadmill effects and reversed ALD decrease. Exercise response was not significantly altered by BR + DO. We conclude the following: (1) BR is an effective antihypertensive agent; (2) BR seems to be acting at both the central and peripheric nervous systems, and (3) the nature of the dopaminergic receptor involved in renin secretion does not seem to be DA(2).