RESUMEN
We present a traumatic fatality of a 19-year-old man who had ingested blotter paper containing 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine]. Postmortem specimens were analyzed by high performance liquid chromatography with tandem mass spectrometry (HPLC/MS/MS). Toxicology findings for fluids based upon blood or urine calibrators were as follows: peripheral blood, 405 pg/mL; heart blood, 410 pg/mL; urine, 2.86 ng/mL; and vitreous humor, 99 pg/mL. While findings based upon the method of standard additions were: gastric contents, 7.1 µg total; bile, 10.9 ng/g; brain, 2.54 ng/g and liver, 7.2 ng/g. To our knowledge the presented case is the first postmortem case of 25I-NBOMe intoxication documented by toxicological analysis of tissues and body fluids.
Asunto(s)
Bencilaminas/análisis , Drogas de Diseño/análisis , Fenetilaminas/análisis , Bencilaminas/química , Bencilaminas/envenenamiento , Bilis/química , Química Encefálica , Cromatografía Liquida , Drogas de Diseño/química , Drogas de Diseño/envenenamiento , Dimetoxifeniletilamina/análogos & derivados , Toxicología Forense , Contenido Digestivo/química , Humanos , Hígado/química , Masculino , Estructura Molecular , Papel , Fenetilaminas/química , Fenetilaminas/envenenamiento , Cambios Post Mortem , Espectrometría de Masas en Tándem , Cuerpo Vítreo/química , Adulto JovenRESUMEN
Hemoglobin (Hb) S and Hb E are the most common variant hemoglobins, but because of the geographical separation of the areas where they are prevalent, the combination of the 2 is uncommon. Approximately 46 cases of hemoglobin SE compound heterozygosity have been reported. No deaths from the condition have been reported previously, whereas death after vigorous physical activity in individuals with sickle cell trait (hemoglobin AS) has been described in a few case reports. Here we report previously undiagnosed hemoglobinopathy SE in a 12-year-old American boy who collapsed during football practice and had a cardiac arrest on the field after a brief lucid interval. The autopsy was significant only for postmortem intravascular sickling. A postmortem hemoglobin electrophoresis test revealed 57% S, 34% E, and 1% F hemoglobins. The death is attributed to cardiac ischemia from functional vaso-occlusion by sickled erythrocytes.