RESUMEN

BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.

Asunto(s)

Genes Virales/genética , Infecciones por VIH/virología , VIH-1 , Herpes Genital/virología , Herpesvirus Humano 2/genética , Brasil , Coinfección/virología , Femenino , Infecciones por VIH/complicaciones , Herpes Genital/complicaciones , Humanos , Filogenia , Reacción en Cadena de la Polimerasa