RESUMEN

This chapter will focus on the therapeutic potential of oligomeric GPCR structures. We will discuss the history of these complexes and their connection with treatment. We will highlight several examples from the literature of complexes of therapeutic or theranostic opportunity. As part of this we will discuss different mechanisms that oligomers use to modulate their partner that could be taken advantage of from a drug targeting perspective. We will also discuss the challenges and hurdles to targeting such complexes.

Asunto(s)

Sistemas de Liberación de Medicamentos , Descubrimiento de Drogas , Péptidos/química , Receptores Acoplados a Proteínas G/química , Sitio Alostérico , Animales , Arrestinas/química , Cristalografía por Rayos X , Diseño de Fármacos , Humanos , Ligandos , Ratones , Medicina de Precisión , Multimerización de Proteína , Transporte de Proteínas , Rodopsina/química , Transducción de Señal