Asunto(s)
Enfermedad Crónica/epidemiología , Personal Militar , Centrales Eléctricas , Traumatismos por Radiación/complicaciones , Liberación de Radiactividad Peligrosa , Adulto , Anciano , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Personal Militar/estadística & datos numéricos , Morbilidad/tendencias , Dosis de Radiación , Federación de Rusia/epidemiología , UcraniaRESUMEN
The resistances to heat and trypsin hydrolysis served as indirect indices of conformational flexibility of glutamate dehydrogenase molecules. No difference in heat resistance was found between crystalline eletrophoretically homogeneous preparations of glutamate dehydrogenase from liver mitochondria of two species of frogs, the more southern Rana ridibunda and the more northern R. temporaria. However, glutamate dehydrogenase from R. ridibunda is digested by trypsin at a lower rate than that from R. temporaria, which may be explained by its lower conformational flexibility. Therefore positive correlation between conformational flexibility of glutamate dehydrogenase and mean ambient temperature of the species studied is revealed only with respect to resistance to proteolysis.