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1.
Rheumatology (Oxford) ; 62(9): 2951-2962, 2023 09 01.
Artículo en Inglés | MEDLINE | ID: mdl-37104741

RESUMEN

OBJECTIVES: This systematic review and meta-analysis synthesizes the evidence on prospective bidirectional associations between sleep-related problems (SRP) and chronic musculoskeletal pain (CMP). METHODS: A literature search for cohort studies available in the PubMed, Scopus, Web of Science, PsycINFO and Cochrane Library databases as of 19 July 2022 was performed. Pooled odds ratios and effect sizes were calculated through random effects meta-analysis. Subgroup and meta-regression analyses were performed to explore differences by follow-up time, proportion of each sex and mean age. The Meta-analysis Of Observational Studies in Epidemiology guidelines were strictly followed. RESULTS: Twenty studies with a total of 208 190 adults (aged 34.4-71.7 years) were included, with 17 of them being used in the meta-analysis. Individuals with SRP at baseline had a 1.79-fold higher incidence (odds ratio [OR] = 1.79; 95% CI: 1.55, 2.08; I2 = 84.7%; P < 0.001) and a 2.04-fold higher persistence (OR = 2.04; 95% CI: 1.42, 2.94; I2 = 88.5%; P < 0.005) of CMP than those without SRP. In the subgroup analysis of the association between SRP and CMP, the longer the follow-up time of the studies, the higher the heterogeneity between them. In the corresponding meta-regression, no significant effect was observed for follow-up time, sex proportion or age. Individuals with CMP at baseline had a 2.02-fold higher incidence of SRP (OR = 2.02; 95% CI: 1.62, 2.53; I2 = 90.0%; P < 0.001) than those without CMP. CONCLUSION: This study provides robust evidence concerning the longitudinal association between SRP and incidence-persistence of CMP in adults. In addition, the available prospective studies support the existence of a bidirectional relationship between CMP and SRP. PROSPERO REGISTRATION NUMBER: CRD42020212360.


Asunto(s)
Dolor Musculoesquelético , Adulto , Humanos , Estudios Prospectivos , Dolor Musculoesquelético/epidemiología , Sueño , Estudios de Cohortes
2.
Behav Sleep Med ; 21(4): 397-410, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-35930240

RESUMEN

OBJECTIVE: To analyze the occupational factors associated with poor sleep quality in correctional officers (COs). METHOD: This is a cross-sectional study involving COs who work at four prison facilities in the state of São Paulo, Brazil. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Logistic and linear regression models were used to calculate the odds ratio (OR) and beta coefficient (ß) of poor sleep quality and the corresponding 95% confidence interval (CI), respectively. The analyses were adjusted for the main confounders. RESULTS: Considering the 256 male COs who participated in the study, 148 (57.8%) had poor sleep quality. In the adjusted analyses, poor sleep quality was associated with higher mental demands (OR = 3.10; 95% CI: 1.40-6.85), having suffered psychological violence at work (OR = 2.13; 95% CI: 1.04-4.35), agreeing with the following statement: "I think about work-related issues in my free time" (OR = 5.13; 95% CI: 1.26-20.78), feeling partially dissatisfied (OR = 2.26; 95% CI: 1.09-4.68) or dissatisfied with work (OR = 4.52; CI: 1.32-15.46) and willingness to find another job (OR = 3.20; 95% CI: 1.53-6.71). The occupational factors dissatisfaction with work (ß = 1.02; 95% CI: 0.05-1.98) and having health problems related to the work environment (ß = 0.32; 95% CI: 0.24-2.41) were also associated with higher scores on the PSQI. CONCLUSION: Poor quality of sleep is a highly frequent health problem among correctional officers, and this condition is associated with the perception of poor working conditions, professional dissatisfaction and the fact that such professionals think about work during their free time.


Asunto(s)
Trastornos del Inicio y del Mantenimiento del Sueño , Calidad del Sueño , Humanos , Masculino , Brasil/epidemiología , Estudios Transversales , Personal de Instituciones Correccionales , Sueño
3.
Physiol Behav ; 254: 113880, 2022 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-35705156

RESUMEN

AIMS: Although both chronic low back pain (cLBP) and sleep problems are prevalent among active workers, the relation between these variables is not well established. This study aimed to examine the bidirectional association between cLBP and sleep in schoolteachers. METHODS: The Pittsburgh Sleep Quality Index (PSQI) and cLBP were self-reported by 530 schoolteachers in Londrina, Brazil, at baseline and after 2 years of follow-up. Generalized estimating equations were adjusted for sociodemographic, lifestyle and mental health variables. RESULTS: Poor sleep quality at baseline was associated with cLBP at follow-up after adjusting for sociodemographic and lifestyle variables (OR=1.61; 95% confidence interval [95% CI]=1.06, 2.47). Changes in the PSQI score over time were also associated with a higher likelihood of cLBP at follow-up (OR=1.13; 95% CI=1.07, 1.20 for each 1-point increase in the PSQI score), regardless of mental health condition. cLBP at baseline was associated with worse sleep quality at follow-up after adjusting for sociodemographic and lifestyle variables (OR=1.56; 95% CI=1.02, 2.37). The presence of cLBP also changed the PSQI score over time (ß coefficient=1.153; 95% CI=0.493, 1.814). CONCLUSIONS: Worse sleep quality was prospectively and bidirectionally associated with cLBP. Concretely, changes in PSQI values after 2 years of follow-up increased the likelihood of reporting cLBP, and baseline cLBP was associated with sleep quality worsening (i.e., higher score in the PSQI). Mental health conditions such as self-rated health, depression and anxiety play a relevant confounding role in the bidirectional associations between sleep and chronic low back pain.


Asunto(s)
Dolor Crónico , Dolor de la Región Lumbar , Trastornos del Sueño-Vigilia , Dolor Crónico/complicaciones , Dolor Crónico/epidemiología , Estudios de Cohortes , Humanos , Dolor de la Región Lumbar/complicaciones , Dolor de la Región Lumbar/epidemiología , Dolor de la Región Lumbar/psicología , Sueño , Calidad del Sueño , Trastornos del Sueño-Vigilia/complicaciones , Trastornos del Sueño-Vigilia/epidemiología
4.
Saf Health Work ; 13(2): 201-206, 2022 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-35664915

RESUMEN

Background: The present objective was to verify whether burnout (emotional exhaustion [EE], depersonalization [DP] and low professional efficacy [PE]) is a risk factor for long-term sickness absence (LTSA; ≥30 consecutive days) from the teaching role. Methods: This was a prospective cohort study with two years of follow-up that investigated 509 elementary and high-school teachers. Burnout was identified by Maslach Burnout Inventory. Poisson regression with robust variance was used to adjust for possible confounders. Results: The incidence of LTSA was 9.4%. High EE levels were associated with LTSA in the crude analysis, but the association lost statistical significance after adjustments (for sex, age, perception of work-life balance, general self-rated health, chronic pain and depression). High DP levels were associated with this outcome, even after all adjustments (relative risk = 1.80; 95% confidence interval: 1.05-3.09). Low PE levels were not related to LTSA. Conclusion: The results reinforce the need to improve teachers' work conditions to reduce burnout, particularly DP, and its consequences.

5.
J Nutr Educ Behav ; 52(5): 503-511, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-31699617

RESUMEN

OBJECTIVE: To explore the associations between the eating habits of sons and daughters and the eating habits, sedentary behavior, and physical activity of their fathers and mothers. DESIGN: A cross-sectional survey of adolescents. SETTING: The 6 largest schools in Londrina, Brazil. PARTICIPANTS: A total of 842 adolescents, 842 mothers, and 842 fathers participated in this study. MAIN OUTCOMES MEASURES: Eating habits of adolescents and sedentary behavior, physical activity, and eating habits of their fathers and mothers, measured by questionnaire. ANALYSIS: The associations were identified by binary logistic regression, adjusted by adolescent's age, family's socioeconomic status, parents' educational level, and the other parental behavior. RESULTS: Independent of educational level and socioeconomic condition, mothers' eating behaviors seem to be more closely related to their adolescent children's eating behavior (vegetables, fruits, fried foods, soft drinks, and sweets [P = .001]) than fathers' behaviors (fried foods and sweets [P = .01], soft drinks [P = .001]). In addition, the behaviors of mothers were more associated to the behaviors of daughters than to the behaviors of sons (7 vs 5 associated behaviors), while behaviors of fathers were more associated with the behaviors of sons than to the behaviors of daughters (4 vs 2 associated behaviors). No associations were noted for sedentary and physical activity behavior and eating behaviors between adolescents and their parents. CONCLUSIONS AND IMPLICATIONS: Many eating habits of adolescents were associated with eating habits of both fathers and mothers, emphasizing the importance of family-focused health promotion actions. Future research is needed incorporating into the analyses, among others, the nutritional statuses and the clustering of healthy and unhealthy behaviors of parents and their children.


Asunto(s)
Conducta del Adolescente/fisiología , Ejercicio Físico/fisiología , Conducta Alimentaria/fisiología , Conductas Relacionadas con la Salud/fisiología , Adolescente , Adulto , Brasil , Estudios Transversales , Dieta/estadística & datos numéricos , Femenino , Humanos , Masculino , Padres , Conducta Sedentaria , Factores Sexuales
6.
J Am Soc Hypertens ; 12(3): 182-189, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29361430

RESUMEN

Hypertension in adolescence may be a predictor of cardiovascular problems in adulthood. Therefore, verification of the factors associated with this condition in adolescence is important. The aim of this study was to analyze the relationship between hypertension in adolescents with hypertension and the sociodemographic characteristics and lifestyle of their parents. This study was conducted on 1231 adolescents, 1202 mothers, and 871 fathers. The blood pressure of the adolescents was measured with an oscillometric device. Details of parental hypertension, sociodemographic characteristics, and lifestyle were obtained by self-report. The prevalence of hypertension was higher among adolescents with older fathers and older mothers, with both parents reporting hypertension and with mothers who were overweight. In multivariable analysis, adolescents with older mothers (OR = 2.36; 95% confidence interval [CI] = 1.12-4.98), hypertensive mothers (OR = 2.22 [95% CI = 1.26-3.89]), and hypertensive fathers (OR = 1.70 [95% CI = 1.03-2.81]) were more likely to have hypertension. In the analysis that considered clusters of health risk factors, higher risks of hypertension were observed in adolescents whose mothers had four or more aggregated risk factors (OR = 2.53 [95% CI = 1.11-5.74]). In conclusion, there was a relationship between hypertension in adolescents and hypertension in their parents. However, an association between hypertension in adolescents and parental age and clusters of health risk factors was only observed for their mothers.


Asunto(s)
Salud del Adolescente/estadística & datos numéricos , Hipertensión/epidemiología , Edad Materna , Padres , Adolescente , Adulto , Factores de Edad , Determinación de la Presión Sanguínea , Brasil/epidemiología , Femenino , Humanos , Hipertensión/diagnóstico , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Riesgo
7.
Behav Med ; 44(4): 335-343, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-28985158

RESUMEN

Chronic pain (CP) is a public health problem with harmful social and individual effects, and its relationships with physical activity (PA) and sedentary behaviors are unclear. This study examined the relationship between CP and PA and time spent watching television as an indicator of leisure time sedentary behavior, and explored the effects of major confounding factors. The information was obtained between 2012 and 2013 from individual interviews with 943 teachers from public schools in Londrina, Brazil. Statistical analysis was performed in 2014 using a logistic regression model adjusted for sociodemographic, lifestyle, depression, and working conditions variables. The prevalence of CP was 31.9%. No statistically significant association was observed between PA and CP. In the adjusted analyses, CP was associated with time > 60 minutes/day spent watching television (odds ratio [OR] = 1.39, 95% confidence interval [CI] 1.03, 1.89) on weekdays. In analyses stratified according to body areas affected by CP, only pain in the lower limbs was associated with more time watching television (OR = 1.62, 95% CI 1.06, 2.47). Watching television on a weekday for > 60 minutes is a sedentary behavior associated with a greater likelihood of teachers having chronic pain, especially in the lower limbs. This association was observed independently of the main confounders such as sex, age, leisure time physical activity, depression and working conditions.


Asunto(s)
Dolor Crónico/psicología , Ejercicio Físico/psicología , Maestros/psicología , Conducta Sedentaria , Adulto , Anciano , Brasil/epidemiología , Dolor Crónico/epidemiología , Estudios Transversales , Femenino , Humanos , Actividades Recreativas/psicología , Masculino , Persona de Mediana Edad , Televisión/estadística & datos numéricos , Factores de Tiempo , Adulto Joven
8.
MedicalExpress (São Paulo, Online) ; 2(1)Jan.-Feb. 2015. tab
Artículo en Inglés | LILACS | ID: lil-777594

RESUMEN

OBJECTIVE: This study examined the prevalence of body weight dissatisfaction and its relationship to physical activity and nutritional status in adolescents. METHOD: The study enrolled 2,288 adolescents. The dependent variable was body weight dissatisfaction. The independent variables were physical activity and nutritional status. The confounders were gender, and economic condition. Associations between dependent and independent variables were analyzed through the chi-square test and the magnitude of the associations was estimated by Poisson regression. RESULTS: A total of 56.6% of adolescents were not satisfied with their weight, with 17.9% wanting to increase it, while 37.7% wanted to decrease their weight. In boys and girls, body weight dissatisfaction was associated with nutritional status, abdominal obesity and physical activity in crude analyses. After adjustments, nutritional status and abdominal obesity remained significantly associated to body weight dissatisfaction in both sexes. CONCLUSION: A high prevalence of body weight dissatisfaction was identified, which was associated with the nutritional status and abdominal obesity in adolescents.


RESUMO OBJETIVOS: Esse estudo teve como objetivo analisar a prevalência de insatisfação com o peso corporal e sua relação com atividade física e estado nutricional em adolescentes. MÉTODO: O estudo envolveu 2.288 adolescentes. A variável dependente foi a insatisfação com o peso corporal. As variáveis independentes foram a atividade física e estado nutricional. Os fatores de confusão foram: sexo e condição econômica. As associações entre as variáveis dependentes e independentes foram analisadas por meio do teste do qui-quadrado e a magnitude das associações foi estimada pela regressão de Poisson. RESULTADOS: Um total de 56,6% dos adolescentes não se declararam satisfeitos com seu peso, 17,9% queriam aumentar, enquanto que 37,7% queriam diminuir o seu peso. Entre meninos e meninas, a insatisfação como peso corporal associou-se com o estado nutricional, obesidade abdominal e atividade física em análises primárias. Após os ajustes, o estado nutricional e a obesidade abdominal permaneceram significativamente associados à insatisfação com o peso corporal em ambos os sexos. CONCLUSÕES: Uma elevada prevalência de insatisfação com o peso corporal foi identificada e associada com o estado nutricional e com obesidade abdominal em adolescentes.


Asunto(s)
Humanos , Adolescente , Peso Corporal , Ejercicio Físico , Estado Nutricional , Obesidad/psicología , Obesidad/epidemiología , Brasil , Prevalencia
9.
Arq. bras. cardiol ; 96(6): 465-470, jun. 2011. ilus, tab
Artículo en Portugués | LILACS | ID: lil-593820

RESUMEN

FUNDAMENTO: A obesidade está ligada à hipertensão arterial (HA) na infância. Entretanto, o papel da gordura como preditor de HA em adolescentes permanece desconhecido. OBJETIVO: Investigar a associação entre obesidade geral e abdominal com HA e identificar a sensibilidade e especificidade desses indicadores para detectar HA em adolescentes. MÉTODOS: A amostra consistiu em 1.021 adolescentes com idade de 10-17 anos. Os indivíduos foram classificados como normal, sobrepeso/obesidade, de acordo com as medidas do IMC, e como não-obeso com obesidade abdominal, de acordo com as medidas da circunferência da cintura (CC). A pressão arterial sistólica (PAS) e diastólica (PAD) foi avaliada através de um dispositivo oscilométrico. Regressão logística e curvas ROC foram usadas na análise estatística. RESULTADOS: A prevalência geral de HA foi 11,8 por cento (13,4 por cento em meninos e 10,2 por cento em meninas). A prevalência de HA em meninos e meninas com sobrepeso/obesidade foi 10 por cento e 11,1 por cento, respectivamente. A prevalência de HA em meninos com obesidade abdominal foi 28,6 por cento. Para ambos os sexos, o odds ratio (OR) para HA foi mais alto na obesidade abdominal do que no sobrepeso/obesidade geral (4,09 [OR IC95 por cento = 2,57-6,51]) versus 1,83 [OR IC95 por cento = 1,83-4,30]). O OR para HA foi mais alto quando sobrepeso/obesidade geral e obesidade abdominal estavam agrupados (OR = 4,35 [OR IC95 por cento = 2,68 -7,05]), do que quando identificados como sobrepeso/obesidade geral ou obesidade abdominal apenas (OR = 1,32 [OR IC95 por cento = 0,65- 2,68]). Entretanto, ambos os tipos de obesidade apresentavam baixo poder preditivo na detecção de HA. CONCLUSÃO: Obesidade geral e obesidade abdominal foram associadas com HA; entretanto, a sensibilidade e especificidade dessas variáveis na detecção de HA são baixas em adolescentes brasileiros.


BACKGROUND: Obesity is linked to high blood pressure (HBP) in childhood. However, the role of fat as a predictor of HBP in adolescents remains unknown. OBJECTIVE: To investigate the association between general and abdominal obesity with HBP and to identify the sensitivity and specificity of these indicators to detect HBP in adolescents. METHODS: The sample was composed of 1,021 adolescents aged 10-17 years. Subjects were classified as normal, overweight/obese, according to BMI measurements, and as non-obese and with abdominal obesity, according to waist circumference (WC) measurements. Systolic (SBP) and diastolic (DBP) blood pressure were assessed using an oscillometric device. Logistic regression and ROC curves were used in the statistical analysis. RESULTS: The overall prevalence of HBP was 11.8 percent (13.4 percent in boys and 10.2 percent in girls). The prevalence of HBP among general overweight/obese boys and girls was 10 percent and 11.1 percent, respectively. The prevalence of HBP among boys with abdominal obesity was 28.6 percent. For both genders, the odds ratio (OR) for HBP was higher in abdominal obesity than in general overweight/obesity (4.09 [OR95 percentCI = 2.57-6.51]) versus 1.83 [OR95 percentCI = 1.83-4.30]). The OR for HBP was higher when general overweight/obesity and abdominal obesity were clustered (OR = 4.35 [OR95 percentCI = 2.68-7.05]), than when identified by either general overweight/obesity or abdominal obesity alone (OR = 1.32 [OR95 percentCI = 0.65-2.68]). However, both types of obesity had low predictive power in HBP detection. CONCLUSION: General and abdominal obesity were associated to HBP, however, the sensitivity and specificity of these variables to detect HBP are low in Brazilian adolescents.


FUNDAMENTO: La obesidad está vinculada a la hipertensión arterial (HA) en la infancia. Sin embargo, el papel de la grasa como predictor de HA en los adolescentes permanece sin conocerse. OBJETIVO: Investigar la asociación entre la obesidad general y abdominal con HA e identificar la sensibilidad y la especificidad de esos indicadores para detectar HA en adolescentes. MÉTODOS: La muestra se constituyó de 1.021 adolescentes con una edad entre los 10 a los 17 años. Los individuos se clasificaron como normal, sobrepeso/obesidad, de acuerdo con las medidas del IMC, y como no obeso con obesidad abdominal, de acuerdo con las medidas de la circunferencia de la cintura (CC). La presión arterial sistólica (PAS) y diastólica (PAD), se evaluaron por medio de un dispositivo oscilométrico. La regresión logística y las curvas ROC fueron usadas en el análisis estadístico. RESULTADOS: La prevalencia general de HA rondó el umbral del 11,8 percent (13,4 percent en niños y 10,2 percent en niñas). La prevalencia de HA en niños y niñas con sobrepeso/obesidad fue 10 percent y 11,1 percent, respectivamente. La prevalencia de HA en niños con obesidad abdominal fue 28,6 percent. Para ambos sexos, el odds ratio (OR) para HA fue más alto en la obesidad abdominal que en el sobrepeso/obesidad general (4,09 [OR IC95 percent = 2,57-6,51]) versus 1,83 [OR IC95 percent = 1,83-4,30]). El OR para HA fue más alto cuando el sobrepeso/obesidad general y la obesidad abdominal estaban agrupados (OR = 4,35 [OR IC95 percent = 2,68-7,05]), que cuando estaban identificados como sobrepeso/obesidad general u obesidad abdominal solamente (OR= 1,32 [OR IC95 percent = 0,65-2,68]). Pero los dos tipos de obesidad presentaban un bajo poder predictivo en la detección de HA. CONCLUSIÓN: La obesidad general y la obesidad abdominal estuvieron asociadas a la HA; pero la sensibilidad y la especificidad de esas variables en la detección de HA son bajas en los adolescentes brasileños.


Asunto(s)
Adolescente , Niño , Femenino , Humanos , Masculino , Índice de Masa Corporal , Presión Sanguínea/fisiología , Hipertensión/diagnóstico , Obesidad Abdominal/epidemiología , Circunferencia de la Cintura/fisiología , Métodos Epidemiológicos , Hipertensión/epidemiología , Obesidad/epidemiología , Factores de Riesgo , Distribución por Sexo
10.
Arq Bras Cardiol ; 96(6): 465-70, 2011 Jun.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-21537530

RESUMEN

BACKGROUND: Obesity is linked to high blood pressure (HBP) in childhood. However, the role of fat as a predictor of HBP in adolescents remains unknown. OBJECTIVE: To investigate the association between general and abdominal obesity with HBP and to identify the sensitivity and specificity of these indicators to detect HBP in adolescents. METHODS: The sample was composed of 1,021 adolescents aged 10-17 years. Subjects were classified as normal, overweight/obese, according to BMI measurements, and as non-obese and with abdominal obesity, according to waist circumference (WC) measurements. Systolic (SBP) and diastolic (DBP) blood pressure were assessed using an oscillometric device. Logistic regression and ROC curves were used in the statistical analysis. RESULTS: The overall prevalence of HBP was 11.8% (13.4% in boys and 10.2% in girls). The prevalence of HBP among general overweight/obese boys and girls was 10% and 11.1%, respectively. The prevalence of HBP among boys with abdominal obesity was 28.6%. For both genders, the odds ratio (OR) for HBP was higher in abdominal obesity than in general overweight/obesity (4.09 [OR(95%CI) = 2.57-6.51]) versus 1.83 [OR(95%CI) = 1.83-4.30]). The OR for HBP was higher when general overweight/obesity and abdominal obesity were clustered (OR = 4.35 [OR(95%CI) = 2.68-7.05]), than when identified by either general overweight/obesity or abdominal obesity alone (OR = 1.32 [OR(95%CI) = 0.65-2.68]). However, both types of obesity had low predictive power in HBP detection. CONCLUSION: General and abdominal obesity were associated to HBP, however, the sensitivity and specificity of these variables to detect HBP are low in Brazilian adolescents.


Asunto(s)
Presión Sanguínea/fisiología , Índice de Masa Corporal , Hipertensión/diagnóstico , Obesidad Abdominal/epidemiología , Circunferencia de la Cintura/fisiología , Adolescente , Niño , Métodos Epidemiológicos , Femenino , Humanos , Hipertensión/epidemiología , Masculino , Obesidad/epidemiología , Factores de Riesgo , Distribución por Sexo
11.
J. pediatr. (Rio J.) ; 77(5): 387-392, set.-out. 2001. tab
Artículo en Portugués | LILACS | ID: lil-303537

RESUMEN

Objetivo: no segundo semestre de 1996, os municípios de Londrina e Curitiba (Paraná) iniciaram a vacinaçãocontra Haemophilus influenzae b (Hib), aproximadamente trinta meses antes de sua introdução no Programa Nacional de Imunização. O presente trabalho objetivou avaliar a incidência da meningite por Hib, entre crianças, em Londrina, Curitiba e nos demais municípios do estado do Paraná, antes e após a introdução da vacina nessas duas cidades. Métodos: foi realizado um estudo observacional retrospectivo de todos os casos de meningite por Hib, entre menores de 5 anos, diagnosticados pelo sistema de vigilância epidemiológica de Londrina e pela Secretaria de Estado da Saúde do Paraná, de 1992 a 1999. Taxas de incidência da meningite por Hib foram calculadas por 100.000 menores de cinco anos. Resultados: comparando com o período anterior à vacinação, houve redução importante do coeficiente de incidência da meningite por Hib em Londrina, passando de 23,91, em 1996, para 2,79 por 100.000 menores de cinco anos, em 1999. Redução semelhante foi observada em Curitiba, enquanto nos demais municípios do Paraná, que não dispunham da vacina até meados de 1999, o coeficiente se manteve praticamente inalterado. Conclusão: a vacinação contra Hib foi efetiva na redução da incidência da meningite entre menores de cinco anos em Londrina e Curitiba. Para a manutenção dessa baixa incidência devem ser garantidas adequada cobertura vacinal e boa qualidade do serviço de vigilância epidemiológica


Asunto(s)
Humanos , Preescolar , Haemophilus influenzae tipo b , Vacunas contra Haemophilus , Meningitis por Haemophilus
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