Asunto(s)
Fármacos Dermatológicos/uso terapéutico , Linfoma Cutáneo de Células T , Terapia PUVA/métodos , Radioterapia/métodos , Neoplasias Cutáneas , Piel/patología , Anciano , Antígenos de Diferenciación de Linfocitos T/análisis , Atrofia , Diagnóstico Diferencial , Manejo de la Enfermedad , Humanos , Linfoma Cutáneo de Células T/diagnóstico , Linfoma Cutáneo de Células T/inmunología , Linfoma Cutáneo de Células T/patología , Linfoma Cutáneo de Células T/terapia , Masculino , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapiaRESUMEN
Shiitake mushroom-induced toxicoderma, or shiitake dermatitis, is a widely recognized phenomenon in Japan, China, and Korea but only recently has been reported outside of Asia. Affected individuals develop a characteristic pattern of whiplike, linear, erythematous wheals within 1 to 2 days after consumption of raw or cooked shiitake mushrooms. Lentinan, a polysaccharide component of shiitake mushrooms with antitumor properties, is thought to instigate a toxic reaction, resulting in the appearance of a rash. Shiitake dermatitis is self-limited and typically resolves within days to weeks of its appearance.
Asunto(s)
Dermatitis/etiología , Intoxicación por Setas/complicaciones , Hongos Shiitake , Dermatitis/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Intoxicación por Setas/patología , Remisión EspontáneaAsunto(s)
Liquen Escleroso y Atrófico/diagnóstico , Esclerodermia Localizada/diagnóstico , Adulto , Antialérgicos/uso terapéutico , Dorso , Biopsia , Cetirizina/uso terapéutico , Humanos , Liquen Escleroso y Atrófico/patología , Masculino , Esclerodermia Localizada/patología , Urticaria/tratamiento farmacológicoAsunto(s)
Vesícula/diagnóstico , Liquen Plano/diagnóstico , Membrana Basal/patología , Vesícula/tratamiento farmacológico , Vesícula/patología , Complemento C3/metabolismo , Dermatitis/diagnóstico , Dermatitis/patología , Fármacos Dermatológicos/uso terapéutico , Eosinofilia/diagnóstico , Femenino , Humanos , Inmunoglobulina G/metabolismo , Liquen Plano/tratamiento farmacológico , Liquen Plano/patología , Persona de Mediana Edad , Trastornos de la Pigmentación/diagnóstico , Trastornos de la Pigmentación/patología , Prurito/diagnóstico , Prurito/patología , Piel/patología , Resultado del TratamientoRESUMEN
Cutaneous T-cell lymphomas most commonly have a CD4(+) memory T-cell phenotype with relatively indolent course, but may in rare cases present with a CD8(+) cytotoxic phenotype exhibiting strikingly more aggressive clinical behavior. We present two cases of the clinically aggressive subtype of primary cutaneous epidermotropic CD8(+) cutaneous T-cell lymphoma and review the current literature, clinical behavior, and recommendations for treatment distinct from that of more common CD4(+) variants of cutaneous T-cell lymphoma.
Asunto(s)
Linfocitos T CD8-positivos/inmunología , Linfoma Cutáneo de Células T/inmunología , Neoplasias Cutáneas/inmunología , Anciano , Anciano de 80 o más Años , Bexaroteno , Terapia Combinada , Humanos , Linfoma Cutáneo de Células T/patología , Linfoma Cutáneo de Células T/terapia , Masculino , Piel/inmunología , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapia , Tetrahidronaftalenos/uso terapéuticoAsunto(s)
Dermis , Neurotecoma/patología , Neoplasias Cutáneas/patología , Adulto , Humanos , Pierna , Masculino , Neurotecoma/cirugía , Neoplasias Cutáneas/cirugíaRESUMEN
BACKGROUND: Endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) has proven to be an effective diagnostic modality for the detection and staging of pancreatic malignancies. In recent years EUS-FNA has also been used to diagnose lesions of non-pancreatic sites such as structures in close proximity to the gut wall within the mediastinum, abdomen, pelvis and retro-peritoneum. AIMS: To evaluate experience with EUS-FNA of non-pancreatic sites at a large university medical centre. METHODS: The study cohort included 234 patients who underwent EUS-FNA of 246 lesions in non-pancreatic sites (122 peri-pancreatic and coeliac lymph nodes; 9 peri-pancreatic masses; other sites: mediastinum 12, gastric 25, liver 27, oesophagus 17, duodenum/colon/rectum 15, retro-peritoneum 8, lung 7, miscellaneous 4). RESULTS: The cytology diagnoses were classified as non-neoplastic/reactive in 82 (33%), atypical/suspicious for malignancy in 25 (10%), malignant in 86 (35%) and non-diagnostic in 53 (22%) cases. Surgical pathology follow-up was available in 75 (31%) cases. Excluding the non-diagnostic cases there were 7 false negative and 3 false positive cases. The sensitivity, specificity and positive predictive value of EUS-FNA in the diagnosis of lesions of non-pancreatic sites was 92%, 98% and 97%, respectively. CONCLUSIONS: EUS-FNA can be effectively used as a diagnostic modality in the diagnosis of lesions from non-pancreatic sites.