RESUMEN

Obiective To study the morphological changes of immature defected skull in later growth. Methods Twenty 2-month small-tail Han sheep (female/male ratio 1:1) were randomly divided into operation group(n=10)and control group(n=10).In the former,the parietal skull of 4 cm in diameter was removed in each sheep so as to observe the growth condition of defected bone.In the latter,the sheep were kept in the same envimnmem as the operation group,but without any operation.Results In the operation group, 2 sheep died from complications and trauma, 2 suffered from cerebral atrophy right under defected area,accompanied with psychiatric symptom,and 1 developed everted growth on the margin of bone window;in the others,the margin of bone window appeared afferent growth,which made the defected area smaller, but the new bone was thin and weak relatively. The rest indexes were not different between the 2 groups. Conclusions Skull defect won't lead to skull development malfomlation, and it can be repaired to some extent by bone growth, but the growth can not close completely the defect and make it strong enough for protecting the brain tissue.