Asunto(s)
Dermatitis Alérgica por Contacto , Eccema , Humanos , Preescolar , Brazo , Prurito/diagnóstico , Prurito/etiología , Extremidad SuperiorAsunto(s)
Cabeza , Neoplasias de la Tiroides , Humanos , Niño , Ultrasonografía , Diagnóstico Diferencial , Ganglios LinfáticosRESUMEN
The cutaneous toxicity of MEK inhibitors may limit treatment adherence. The authors present a retrospective study of 41 paediatric patients with NF-1 undergoing therapy with selumetinib and propose a treatment algorithm.
Asunto(s)
Paroniquia , Enfermedades de la Piel , Humanos , Niño , Estudios Retrospectivos , Paroniquia/inducido químicamente , Inhibidores de Proteínas Quinasas/efectos adversos , Enfermedades de la Piel/inducido químicamente , Quinasas de Proteína Quinasa Activadas por Mitógenos/efectos adversosRESUMEN
Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1ß, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.
Asunto(s)
Coinfección , Privación de Alimentos , Helmintiasis/parasitología , Parasitosis Intestinales/parasitología , Pulmón/microbiología , Mycobacterium tuberculosis/patogenicidad , Nematospiroides dubius/patogenicidad , Infecciones por Strongylida/parasitología , Tricuriasis/parasitología , Trichuris/patogenicidad , Tuberculosis Pulmonar/microbiología , Fenómenos Fisiológicos Nutricionales de los Animales , Animales , Citocinas/metabolismo , Modelos Animales de Enfermedad , Progresión de la Enfermedad , Femenino , Helmintiasis/inmunología , Helmintiasis/metabolismo , Interacciones Huésped-Parásitos , Mediadores de Inflamación/metabolismo , Parasitosis Intestinales/inmunología , Parasitosis Intestinales/metabolismo , Pulmón/inmunología , Pulmón/metabolismo , Masculino , Ratones Endogámicos C3H , Mycobacterium tuberculosis/inmunología , Nematospiroides dubius/inmunología , Estado Nutricional , Infecciones por Strongylida/inmunología , Infecciones por Strongylida/metabolismo , Tricuriasis/inmunología , Tricuriasis/metabolismo , Trichuris/inmunología , Tuberculosis Pulmonar/inmunología , Tuberculosis Pulmonar/metabolismoRESUMEN
Papular epidermal nevus with "skyline" basal cell layer (PENS) is a keratinocytic nevus that can occur sporadically or has a familial transmission. There are 5 families reported with PENS, in which there are 2 family members affected with each case. We present the sixth familial case, with the peculiarity of being the first time in which there are 3 family members with PENS, while reviewing the other cases described until now. In addition, we present a new histopathological finding, an inflammatory lichenoid infiltrate on the upper dermis in PENS lesions. This finding could be the result of trauma to the biopsied lesion, or it may represent a new inflammatory histological variant.
Asunto(s)
Nevo/patología , Adulto , Niño , Femenino , Humanos , Lactante , Masculino , LinajeAsunto(s)
Dermatitis Alérgica por Contacto/etiología , Dermatitis Profesional/etiología , Dermatosis de la Mano/etiología , Goma/efectos adversos , Anciano , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Profesional/diagnóstico , Diagnóstico Diferencial , Guantes Protectores , Humanos , Masculino , Psoriasis/diagnóstico , Ingeniería SanitariaRESUMEN
Immune reconstitution inflammatory syndrome (IRIS) represents paradoxical immune-mediated inflammation in response to an infecting pathogen, occurring after initiation of antiretroviral therapy (ART), concomitantly with immune system recovery. It has also been described in Kaposi's sarcoma (KS). We report a case of a 9-year-old Guinean girl, who developed Kaposi's sarcoma, following introduction of ART. KS associated with immune reconstitution inflammatory syndrome is rare, especially in children, but with the increased use of ART is becoming more prevalent.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/tratamiento farmacológico , Fármacos Anti-VIH/efectos adversos , Fármacos Anti-VIH/uso terapéutico , Terapia Antirretroviral Altamente Activa/efectos adversos , Síndrome Inflamatorio de Reconstitución Inmune/inducido químicamente , Sarcoma de Kaposi/tratamiento farmacológico , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Niño , Didesoxinucleósidos/administración & dosificación , Didesoxinucleósidos/efectos adversos , Quimioterapia Combinada , Femenino , Humanos , Síndrome Inflamatorio de Reconstitución Inmune/etiología , Lamivudine/administración & dosificación , Lamivudine/efectos adversos , Lopinavir/administración & dosificación , Lopinavir/efectos adversos , Ritonavir/administración & dosificación , Ritonavir/efectos adversos , Sarcoma de Kaposi/etiología , Sarcoma de Kaposi/patologíaAsunto(s)
Dermatitis Alérgica por Contacto/etiología , Ácido Pantoténico/análogos & derivados , Crema para la Piel/efectos adversos , Complejo Vitamínico B/efectos adversos , Administración Oral , Antiinflamatorios/uso terapéutico , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Ácido Pantoténico/efectos adversos , Pruebas del Parche , Prednisolona/uso terapéutico , Crema para la Piel/químicaAsunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Artralgia/tratamiento farmacológico , Vesícula/inducido químicamente , Celecoxib/uso terapéutico , Erupciones por Medicamentos/etiología , Etoricoxib/efectos adversos , Antiinflamatorios no Esteroideos/uso terapéutico , Vesícula/diagnóstico , Erupciones por Medicamentos/diagnóstico , Femenino , Humanos , Persona de Mediana Edad , Pruebas del ParcheRESUMEN
Abstract: Rapidly involuting congenital hemangioma is a rare vascular tumor that generally has a good prognosis. The authors describe a case of a newborn girl with a left cervical vascular lesion. Image exams were performed, and the lesion slowly decreased, leaving redundant skin. Considering all of the findings, a final diagnosis of a rapidly involuting congenital hemangiomas was suspected.