RESUMEN
The effects of Tissucol on alveolar healing following stress were evaluated histologically, comparing three groups of 28 male albino rats each. Stress was applied and their right upper incisors were extracted. Group A served as an empty control site. In Group B, Tissucol was applied into the alveolar cavity. Group C received local antifibrinolytic treatment (alveolar irrigation with epsilon-aminocaproic acid solution) before implant of Tissucol into the tooth socket. Four animals in each group were killed at 1, 3, 6, 9, 15, 21 and 24 days after surgery. Results showed that: 1) Tissucol did not interfere with connective and osseous tissue formation; 2) Tissucol allowed new bone formation; 3) Tissucol residues in Group B in sections of 24-day specimens did not impair healing; 4) Tissucol was usually completely resorbed and healing was complete 24 days after surgery in Group C.
Asunto(s)
Proceso Alveolar/efectos de los fármacos , Adhesivo de Tejido de Fibrina/farmacología , Estrés Fisiológico/fisiopatología , Adhesivos Tisulares/farmacología , Cicatrización de Heridas/efectos de los fármacos , Proceso Alveolar/fisiopatología , Animales , Incisivo/cirugía , Masculino , Maxilar , Ratas , Ratas Wistar , Restricción Física , Factores de Tiempo , Extracción DentalRESUMEN
The effects of Tissucol and Tissucol/EACA on bone healing were evaluated histologically. Experimental defects were made in both tibias of 25 rats. Test materials were placed in defects in right tibias and left tibias served as control. Five animals in each group were killed at 1, 3, 7, 14 and 21 days after surgery. Results showed that: a) Tissucol did not interfere with connective and osseous tissue formation; b) Tissucol allowed new bone formation; c) Tissue residues in Tissucol groups in sections of 21-day specimens did not impair healing; d) Tissucol/EACA was usually completely resorbed and healing was complete 21 days after surgery in the Tissucol/EACA group.
Asunto(s)
Ácido Aminocaproico/farmacología , Regeneración Ósea/efectos de los fármacos , Adhesivo de Tejido de Fibrina/farmacología , Hemostáticos/farmacología , Cicatrización de Heridas/efectos de los fármacos , Ácido Aminocaproico/uso terapéutico , Animales , Adhesivo de Tejido de Fibrina/uso terapéutico , Hemostáticos/uso terapéutico , Masculino , Odontogénesis/efectos de los fármacos , Prótesis e Implantes , Ratas , Ratas Wistar , Irrigación Terapéutica , TibiaRESUMEN
The interference of a blood clot in the first postoperative hours of dental extraction wounds was studied in rats. Sixty male albino rats were divided into two groups: Group I, immediately after extraction of right maxillary incisor the gingival mucosa was approximated and sutured; Group II, after 6 to 8 minutes postoperatively the blood clot was removed with saline irrigation and absorbent paper cones. The mucosa was then approximated and sutured. Six animals in each group were sacrificed after 12 hours, 1, 4, 7 and 10 days. There was a profound delay in healing in Group II since, although a new blood clot was later formed, it was not organized. The quality and the constitution, maintenance and retraction of the clot are the regulating factors in connective tissue formation during alveolar healing.