RESUMEN

Several new pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-g) and their corresponding heterocycle moieties (3a-g) were synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). The derivatives 3c and 3d showed modest inhibitory activity against vaccinia virus reaching 70% at a concentration of 100 microM. All heterocyclic compounds (3a-f) showed a modest inhibition against HSV-1, reaching the maximal inhibitory effect around 20-30%. The antiviral effects of most of the pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-f) on VV and HSV were not impressive.

Asunto(s)

Antivirales/síntesis química , Antivirales/farmacología , Pirazoles/farmacología , Quinolinas/farmacología , Ribonucleósidos/síntesis química , Ribonucleósidos/farmacología , Animales , Línea Celular , Herpesvirus Humano 1/efectos de los fármacos , Humanos , Pirazoles/química , Quinolinas/química , Virus Vaccinia/efectos de los fármacos , Replicación Viral/efectos de los fármacos