RESUMEN
Blood and its products are valuable therapeutic resources for the pediatrician who care for newborns with severe illnesses. The use of blood and its products requires for the hospital personnel working at neonatal care units to be precise and up to date on the indications and complications of total blood, the globular package, albumin, plasma, the concentration of granulocytes, platelets and immunoglobulins for intravenous use. This review gathers, on the one hand, accumulated experiences by the members of the Commission of Blood and its Products from the Pediatric Hospital of the National Medical Center and on the other hand, a selection of the more important concepts which have been judged so by the authors and expressed in the current medical literature.
Asunto(s)
Transfusión Sanguínea , Enfermedades del Recién Nacido/terapia , Transfusión de Eritrocitos , Granulocitos/trasplante , Humanos , Inmunoglobulinas Intravenosas/administración & dosificación , Recién Nacido , Plasma , Transfusión de Plaquetas , Albúmina Sérica/administración & dosificación , Albúmina Sérica/efectos adversos , Reacción a la TransfusiónRESUMEN
The case of a 9-year old girl with end-stage refractory pre-B CD10/CALLA positive acute lymphoblastic leukaemia is described. The patient was treated with high doses of cytarabine followed by intravenous anti-CD10 monoclonal antibody (J5) in an effort to prevent the recovery of the leukemic CD10 positive clone following the bone marrow hypoplasia resulting from the chemotherapy. The number of CD10 positive cells dissapeared both in the peripheral blood as well as in the bone marrow, but when granulocytic recovery ensued, the patient died from respiratory infection. No evidence of antigenic modulation of the CD10 antigen was observed in the blast cells.
Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Anticuerpos Antineoplásicos/uso terapéutico , Antígenos de Diferenciación/inmunología , Antígenos de Neoplasias/inmunología , Leucemia-Linfoma Linfoblástico de Células Precursoras B/terapia , Terapia Recuperativa , Anticuerpos Monoclonales/inmunología , Anticuerpos Antineoplásicos/inmunología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Asparaginasa/administración & dosificación , Niño , Terapia Combinada , Ciclofosfamida/administración & dosificación , Citarabina/administración & dosificación , Daunorrubicina/administración & dosificación , Daunorrubicina/análogos & derivados , Femenino , Humanos , Mercaptopurina/administración & dosificación , Metotrexato/administración & dosificación , Neprilisina , Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras B/inmunología , Prednisona/administración & dosificación , Inducción de Remisión , Tenipósido/administración & dosificación , Vincristina/administración & dosificaciónAsunto(s)
Lupus Eritematoso Sistémico/clasificación , Anemia/etiología , Autoanticuerpos/análisis , Niño , Dermatosis Facial/etiología , Femenino , Fiebre/etiología , Humanos , Enfermedades Renales/etiología , Leucopenia/etiología , Lupus Eritematoso Sistémico/inmunología , Lupus Eritematoso Sistémico/patología , Masculino , Estudios RetrospectivosAsunto(s)
Anemia Aplásica/tratamiento farmacológico , Anemia de Fanconi/tratamiento farmacológico , Anomalías Múltiples , Médula Ósea/patología , Niño , Anemia de Fanconi/sangre , Anemia de Fanconi/patología , Femenino , Hemoglobinas/análisis , Hemorragia/etiología , Humanos , Lactante , Recién Nacido , Discapacidad Intelectual/etiología , Recuento de Leucocitos , Masculino , Oximetolona/uso terapéuticoRESUMEN
We present in this paper two cases of auto-immune hemolytic anemie caused by ingestion of alpha-metildope Coombs' test positive. We suggest to make Coombs test to every patient in whose treatment has been included the use of alpha-metildope.
Asunto(s)
Anemia Hemolítica Autoinmune/inducido químicamente , Metildopa/efectos adversos , Administración Oral , Adulto , Anemia Hemolítica Autoinmune/inmunología , Climaterio/efectos de los fármacos , Prueba de Coombs , Femenino , Humanos , Hipertensión/tratamiento farmacológico , Masculino , Metildopa/administración & dosificación , Persona de Mediana EdadRESUMEN
Two new cases of hemoglobin S-beta thalassemia are being reported. Twenty-six relatives are studied. The two cases were classified as Mediterranean variety. The diagnostic problem and the therapeutical possibilities are considered.
Asunto(s)
Talasemia/genética , Femenino , Hemoglobinas Anormales/análisis , Humanos , Masculino , México , Linaje , Talasemia/sangre , Talasemia/inmunologíaRESUMEN
Hereditary thrombocytopathic thrombocytopenia is reported in a family (mother and son) and is transmitted with dominant character of moderate to severe intensity (platelets fluctuated from less than 5,000 per mm-3 to 20,000 with sporadic higher rises), normal survivorhship, larger than normal diameter and abnormal platelet 3 factor. Comments are made on its resemblance to idiopathic thrombocytopenic purpura and stress is placed on the importance of its identification through the decision of splenectomy with negative results in these patients.
Asunto(s)
Genes Dominantes , Púrpura Trombocitopénica Trombótica/genética , Autopsia , Recuento de Células Sanguíneas , Factores de Coagulación Sanguínea/análisis , Plaquetas/patología , Niño , Femenino , Humanos , Recién Nacido , Masculino , Linaje , Embarazo , Púrpura Trombocitopénica Trombótica/sangre , Púrpura Trombocitopénica Trombótica/patología , EsplenectomíaRESUMEN
Thirty-two patients with hereditary hemorrhagic diseases and a platelet functional abnormality were set apart from our group of patients with hereditary hemorrhagic diseases, and their symptoms, signs and hematological examinations were collected; the initial events and the age of the patients when they were obsserved, the main hemorrhagic manifestations during their clinical course, the clinical severity of the disorders, the survival of the patients and the laboratory test for hemostasis useful to make the diagnosis, were evaluated. In reference to bleeding time, thirty patients had abnormal bleeding time, but the other two had normal bleeding time.