RESUMEN
SARS-CoV-2 infection in children produces mild respiratory symptoms or no symptoms at all in most cases. Some pediatric patients develop a severe complication associated with high mortality, the multisystem inflammatory syndrome in children (MIS-C). In both scenarios, there are reports of neurological manifestations. This article aims to review the cases of pediatric patients with severe neurological issues and a coexisting positive SARS-CoV-2 test. A literature search was performed between March 2020 and May 2021. The results included the data from 41 studies, with 159 children with severe neurological manifestations, within an age range from 24 h to 17 years. The neurological disorders included 38 cases with stroke, 32 with encephalitis, 22 with encephalopathy, and 10 with Guillain-Barre syndrome. Sixty-five out of 159 cases with severe neurological manifestations were diagnosed with MIS-C. Direct neuroinvasion and the exaggerated immune response in some patients seem to be the most critical factors triggering these manifestations. Further research in the ongoing pandemic is needed to elucidate the precise mechanism.
RESUMEN
La hemidisplasia congénita con ictiosis y defectos de las extremidades o síndrome de CHILD, es una enfermedad infrecuente (solo 30 casos reportados en la literatura), hereditaria, monogénica, que se transmite como un rasgo dominante ligado al cromosoma X. Se presenta el caso de una paciente de 17 años de edad con este diagnóstico neonatal, que presentó al momento del nacimiento eritrodermia ictiosiforme en el hemicuerpo izquierdo, acompañada de hipomelia del miembro superior e inferior izquierdos, defectos óseos en miembros afectados y columna vertebral (escoliosis), entre otras. Se realizaron las interconsultas, estudios ultrasonográficos y radiológicos para completar el diagnóstico y se ofreció asesoramiento genético. Evolucionó satisfactoriamente hasta los 16 años, edad en la que comenzó a padecer de frecuentes infecciones(AU)
Congenital hemidysplasia with ichthyosis and limb defects or CHILD syndrome is a rare disorder (only 30 cases reported on medical literature), monogenic inherited in an X-linked dominant trait. A 17 year old-female patient having the diagnosis at birth is the case presented. At birth the patient presented ichthyosiform erythroderma on left hemi-body with hypomelia of left superior and inferior limbs, osseous defects in the members affected and vertebral column (scoliosis), among other anomalies. Medical consultations, sonographic and radiological studies to complete the diagnosis and genetic counselling were conducted. The patient had a satisfactory development up to 16 years old, the age where frequent infections appeared(AU)
Asunto(s)
Humanos , Enfermedades Cutáneas Genéticas , Anomalías CongénitasRESUMEN
La investigación presenta un estudio del desarrollo de la especialidad de Medicina Interna en Pinar del Río. El objetivo propuesto fue valorar el desarrollo de las especialidades de Medicina Interna, Medicina General Integral y Gastroenterología en Pinar del Río. La metodología utilizada es la que plantea la Filosofía Marxista. Es una investigación novedosa por cuanto existe muy poca información sobre esta temática y ofrece valiosos elementos basados en la escasa literatura que existe del tema y en los testimonios de los propios protagonistas. Puede servir como material de consulta y para futuras investigaciones, teniendo en cuenta los resultados y conclusiones expresan que el desarrollo de médico en Pinar del Río fue el producto del propio incremento de la información científica, las necesidades de la población y una voluntad política que se hizo realidad con el triunfo de la Revolución...(AU)
This research paper presents a study of the Internal Medicine development in Pinar del Rio province. This study was aimed at assessing the medical specialties of internal medicine, comprehensive medicine and gastroenterology in the province. Marxist Philosophy was the methodology presented to conduct this study. This a completely new research, thus theres not much information about the topic, offering valuable elements based on the lack of literature for the topic as well as in the testimonies of their own protagonists. This paper can be of reference for future researches. Taking into account the results we concluded that the medical development in Pinar del Rio was determined by the enhancement of the scientific information, the needs of the population and the political will, which became true after the Triumph of the Revolution...(AU)