RESUMEN
We aimed to investigate the relationship between cortisol levels and bone mineral density (BMD) among premenopausal women with major depression. We compared BMD, plasma cortisol, osteocalcin and C-telopeptide (CTx) levels of 36 premenopausal women with major depression with 41 healthy women who were matched for age and body mass index. Osteocalcin and CTx were used for the evaluation of bone turnover. The clinical diagnosis of major depression was made by using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. The 21-item Hamilton Rating Scale for Depression was used for the assessment of depressive symptoms. In comparison with the controls, the mean BMD of the depressed women was significantly lower at the lumbar spine and at all sites of the proximal femur (p = 0.02, 0.01). Plasma cortisol levels were significantly higher in depressive patients than in controls (p = 0.001). Osteocalcin was lower and CTx was higher in the patient group than in controls (p = 0.04, p = 0.008). Lumbar and femur BMD scores were negatively correlated with cortisol levels in the patient group. Major depression had important effects on BMD and bone turnover markers. Depression should be considered among risk factors for osteoporosis in premenopausal women.
Asunto(s)
Densidad Ósea/fisiología , Trastorno Depresivo Mayor/sangre , Hidrocortisona/sangre , Osteoporosis/etiología , Adulto , Biomarcadores/sangre , Índice de Masa Corporal , Peso Corporal , Estudios de Casos y Controles , Trastorno Depresivo Mayor/complicaciones , Femenino , Humanos , Persona de Mediana Edad , Osteoporosis/prevención & control , Premenopausia/sangre , Escalas de Valoración PsiquiátricaRESUMEN
Rabbit syndrome is characterized by rapid, fine, rhythmic movements of the perioral muscles along a vertical axis, mimicking the chewing actions of a rabbit. The present case demonstrates the possible usefulness of quetiapine as a mono-drug treatment strategy for dealing with rabbit syndrome and simultaneously treating psychotic symptoms.
Asunto(s)
Antipsicóticos/efectos adversos , Enfermedades de los Ganglios Basales , Dibenzotiazepinas/uso terapéutico , Discinesia Inducida por Medicamentos/complicaciones , Labio/fisiopatología , Periodicidad , Adulto , Antipsicóticos/uso terapéutico , Enfermedades de los Ganglios Basales/inducido químicamente , Enfermedades de los Ganglios Basales/complicaciones , Enfermedades de los Ganglios Basales/tratamiento farmacológico , Discinesia Inducida por Medicamentos/tratamiento farmacológico , Discinesia Inducida por Medicamentos/etiología , Humanos , Masculino , Fumarato de Quetiapina , Esquizofrenia/tratamiento farmacológico , SíndromeRESUMEN
Many psychiatric disorders can be seen in patients with chronic renal failure (CRF). Haemodialysis (HD), which is a renal replacement treatment, causes various psychiatric and psychosocial problems. Patients are dependent on treatment and the illness causes various problems. In addition, strict diet and continuous treatment are other stress factors (1,2). Various studies have been published in different regions and countries about the prevalence of depression and the relation between sociodemographic factors and depression in patients treated by continuous ambulatory peritoneal dialysis (CAPD), which has gradually become common in Turkey. However studies, which reflect the authors' region, have become necessary (2,3).