RESUMEN
The aim of the study was to determine a complex of clinical and biological factors capable to serve as criteria for early prognosis of attack-like progredient schizophrenia course. Three hundred patients with attack-like progredient schizophrenia comprised two groups--with poor outcome and with favorable one. Clinical features of the disease at its early stage, premorbid peculiarities, family history, organism reactivity (type of higher nervous activity, type of familial biochemical polymorphism, immunogenetic features) were studied. Multifactor mathematical analysis enabled to determine and to present a contribution of each factor to the disease prognosis as a quantitative index (prognostic coefficient) and to design an appropriate prognostic table that allows practitioners to determine a disease course prognosis with higher probability.
Asunto(s)
Esquizofrenia/diagnóstico , Adulto , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Índice de Severidad de la EnfermedadRESUMEN
The clinico-follow-up study of 90 patients with recurrent schizophrenia with an early onset (up to 20 years) permitted to depict peculiarities of the clinical picture and the course at a remote period of the disease depending upon the clinical manifestations of the previous stage and the degree of the progressiveness. An analysis of the clinical material has demonstrated that periodic schizophrenic with an early onset contains, as well as in adults, various variants of the course that differ in the degree of progressiveness (mild cyclothimuc, reduced, "cliche" and complicated states) which most likely condition a different level of "outcome": from the mild ones on the level of psychic asthenia up to more expressed in the form of personality autization of a different degree. The stated negative symptomatology was determined on the background of asthenical remission of a combined character (affective and asthenical disorders).