RESUMEN
Epidermodysplasia verruciformis (EV) is a rare, lifelong, autosomal recessive genodermatosis characterized by susceptibility to certain human papillomavirus (HPV) types and increased risk of skin cancer. This report describes a 22-year-old male presenting with multiple flat erythematous papules on the trunk and extremities. Histopathological examination of a skin biopsy revealed features consistent with EV, including hypergranulosis, hyperkeratosis, and acanthosis, with notable keratohyalin granules and perinuclear vacuolization of keratinocytes. No mitotic activity or cellular atypia was observed. This case underscores the importance of early diagnosis and management of EV, which includes genetic counseling, photoprotection, and regular monitoring for premalignant lesions. Treatment options, ranging from pharmacologic interventions to surgical excision, aim to mitigate the risk of malignant transformation. This report highlights the clinical and histopathological presentation of EV, contributing to the understanding and management of this rare genodermatosis.
RESUMEN
OBJECTIVES: Patients with vitiligo experience emotional and psychological stress as they undergo long-term therapy. The debilitating psychosocial effects of this disease on patients' quality of life is well-documented. This study evaluates the effect of the introduction of narrow-band ultraviolet-B (NB-UVB) therapy on the quality of life of patients with vitiligo in Almadinah Almunawwarah, KSA. METHODS: Thirty-eight patients from the main dermatology center of Ohud Hospital, Almadinah Almunawwarah, were interviewed between June 2017 and March 2019 using the Dermatology Life Quality Index (DLQI) questionnaire. The interviews were conducted before and one year after the course of NB-UVB therapy, which was added as a new treatment modality to the basic therapeutic regimen of topical medications. RESULTS: The patients' response to vitiligo therapy was positive. The overall patient satisfaction score regarding the NB-UVB therapy was as high as 9.1 out of 10. The initial overall DLQI score (5.67 ± 0.90) markedly decreased after the NB-UVB therapy (3.08 ± 0.56), indicating a significant improvement. The patients' adherence to the follow-up visits also improved. CONCLUSION: NB-UVB therapy is effective in alleviating psychological stress and improving the quality of life of patients with vitiligo.