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Objectives: The transcription factor 7-like 2 gene (TCF7L2) is associated with a predisposition to type 2 diabetes mellitus (T2DM) in different ethnic populations. This article investigated the relationship between TCF7L2 gene expression and several biochemical indexes among different age categories of T2DM in a sample of the Iraqi population. Methods: One hundred and fifty blood samples were collected from three groups: young T2DM (10-35 years), old T2DM (40-80 years), and healthy control (10-65 years) groups. Both sexes were enrolled. qPCR was performed to explore the expression of the TCF7L2 gene. Biochemical tests were performed to assess hemoglobin A1C (HbA1c), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels. The body mass index (BMI) was calculated. The results were statistically analyzed. Results: Patients with T2DM had higher BMI, TG, and LDL, and lower HDL than the control group. There was a strong positive correlation between hemoglobin A1C (HbA1c) and BMI, TG, and LDL and a negative correlation between HbA1c and HDL. Expression of the TCF7L2 gene showed a significant difference between old and young patients by 1.68 and 0.207 fold, respectively. These results showed that old patients had higher gene expression than young patients. Conclusion: TCF7L2 gene expression was affected by age, with higher expression in old T2DM patients. This may influence beta cell functions and insulin secretion.

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The presence of a wastewater treatment plant in the Arab El-Madabegh region, which discharges excessive amounts of raw effluent toward the nearby farming fields, is the area's main issue. Examining the harmful implications of raw effluent releases on groundwater quality, determining if treated wastewater effluent complies with regulations for discharge into the aquatic environment, and assessing irrigation appropriateness by the effluent are the main goals of this work. In order to accomplish these targets, twelve treated effluent samples from the Arab El-Madabegh wastewater treatment plant were gathered every two weeks starting in January 2012 and finishing in June 2012. They were tested to determine pH, Total Dissolved Solids (TDS), Total Suspended Solids (TSS), Temperature (Temp), Conductivity (EC), Turbidity (Turb.), Chemical Oxygen Demand (COD), Biological Oxygen Demand (BOD), Total Organic Carbon (TOC), NO3-, SO42-, Cl-, Ca2+, PO43-, HCO3-, Na+, Mg2+, and heavy metals such as (Fe, Mn, K+, Cr, Pb, Zn, Ni, Cu, and Cd). The outcomes revealed that all Egyptian and Food and Agricultural Organization (FAO) standards for unrestricted irrigation were met by the treated effluents, except for COD, which exceeded than the Egyptian allowed limit. The evaluation indices of the effluent's EC, SAR, PI, MR, and MH were in the low-risk category according to indicators of water quality for irrigation, nevertheless, The SSP and RSC both showed slightly higher values (67.9% and 2.76, respectively). As well, The average values of heavy metals in treated wastewater effluent were found to be below permitted limits, with the exception of lead and phosphate, which exceeded permissible limits in Egypt. The environmental sustainability (ecological friendliness) of reusing and recycling tertiary treated wastewater can be achieved in agriculture to reduce the adverse impacts on the aquatic environment.

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Since soft computing has gained a lot of attention in hydrological studies, this study focuses on predicting aeration efficiency (E20) using circular plunging jets employing soft computing techniques such as reduced error pruning tree (REPTree), random forest (RF), and M5P. The study undertaken required the development and validation of models, which were achieved using 63 experimental data values with input variables, such as angle of inclination of tilt channel (α), number of plunging jets (JN), discharge of each jet (Q), hydraulic radius of each jet (HR), and Froude number (Fr. No), to evaluate the aeration efficiency (E20), which served as the output variable. To evaluate the effectiveness of the developed models, three different statistical indices were used such as the coefficient of correlation (CC), root-mean-square error (RMSE), and mean absolute error (MAE), and it was found that all of the applied techniques possessed good forecasting ability since their correlation coefficient values were greater than 0.8. Upon testing, it was discovered that the M5P model outperformed other soft computing-based models in its ability to predict E20, as demonstrated by its correlation coefficient value of 0.9564 and notably low values of MAE (0.0143) and RMSE (0.0193).

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Jet aeration is a commonly used technique for introducing air into water during wastewater treatment. In this investigation, the efficacy of different soft computing models, namely, Random Forest, Reduced Error Pruning Tree, Artificial Neural Network (ANN), Gaussian Process, and Support Vector Machine, was examined in predicting the aeration efficiency (E20) of circular and square jet configurations in an open channel flow. A total of 126 experimental data points were utilized to develop and validate these models. To assess the models' performance, three goodness-of-fit parameters were employed: correlation coefficient (CC), root-mean-square error (RMSE), and mean absolute error (MAE). The analysis revealed that all of the developed models exhibited predictive capabilities, with CC values surpassing 0.8. Nonetheless, when it comes to predicting E20, the ANN model outperformed other soft computing models, achieving a CC of 0.9748, MAE of 0.0164, and RMSE of 0.0211. A sensitivity analysis emphasized that the angle of inclination exerted the most significant influence on the aeration in an open channel. Furthermore, the results demonstrated that square jets delivered superior aeration compared to that of circular jets under identical operating conditions.

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The threat posed by invasive non-native species worldwide requires a global approach to identify which introduced species are likely to pose an elevated risk of impact to native species and ecosystems. To inform policy, stakeholders and management decisions on global threats to aquatic ecosystems, 195 assessors representing 120 risk assessment areas across all six inhabited continents screened 819 non-native species from 15 groups of aquatic organisms (freshwater, brackish, marine plants and animals) using the Aquatic Species Invasiveness Screening Kit. This multi-lingual decision-support tool for the risk screening of aquatic organisms provides assessors with risk scores for a species under current and future climate change conditions that, following a statistically based calibration, permits the accurate classification of species into high-, medium- and low-risk categories under current and predicted climate conditions. The 1730 screenings undertaken encompassed wide geographical areas (regions, political entities, parts thereof, water bodies, river basins, lake drainage basins, and marine regions), which permitted thresholds to be identified for almost all aquatic organismal groups screened as well as for tropical, temperate and continental climate classes, and for tropical and temperate marine ecoregions. In total, 33 species were identified as posing a 'very high risk' of being or becoming invasive, and the scores of several of these species under current climate increased under future climate conditions, primarily due to their wide thermal tolerances. The risk thresholds determined for taxonomic groups and climate zones provide a basis against which area-specific or climate-based calibrated thresholds may be interpreted. In turn, the risk rankings help decision-makers identify which species require an immediate 'rapid' management action (e.g. eradication, control) to avoid or mitigate adverse impacts, which require a full risk assessment, and which are to be restricted or banned with regard to importation and/or sale as ornamental or aquarium/fishery enhancement.

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Ethical challenges facing research and reporting from conflict-affected zones are well known; among them is the difficulty of finding reliable information; the tendency to take sides and define actors as either good or evil; the precarious security situation of residents and the ever-changing scenarios on the ground. We observed, however, that these challenges go unacknowledged in research and reporting on health state and on the health system from the conflict in Iraq and Syria, with the lines between science and journalistic reporting routinely blurred in the literature. What should be the restraining factor of academic research against prejudiced reporting on injury, death and the healthcare system has mostly failed in the Syrian conflict. Even social media, with its promise of 'independent' and 'citizens' voice', can be skewed, with much of the output in the Syria crisis coming from one side only, largely due to access issues. While researchers in conflict-affected zones, such as Syria, may need to take a position on one side or another when reporting, death, destruction and disease, it is important that they admit to the challenges of accessing unbiased data, the near impossibility of obtaining representative samples and the risk of the contamination of evidence, clinical or otherwise. The example of the Syrian and Iraqi conflicts (as context) indicates a need to reassess research ethics in conflict zones and their implications for policy.

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Sixty-three Arabic patients (16 males and 47 females) with thyroid toxic and nontoxic goiter who attended the endocrinologist in Nuclear Medicine Hospital and Al Yarmok Nuclear Medicine Department in Baghdad, Iraq were examined for thyroid peroxidase (TPO) gene mutations. A total of ten heterozygous mutations have been identified in the human TPO gene associated with thyroid toxic and nontoxic goiter. These mutations involved transition or transversion of cysteine either by thymine or guanine at the position 1708 of the exon 10 (c.1708C>T) and the position 1978 of the exon 11 (c.1978C>G). From a total of ten detected mutations, two c.1978C>G mutations were detected in nontoxic goiter patients and eight (two c.1708C>T and six c.1978C>G mutations) were detected in toxic goiter. In conclusion, this study identified ten TPO mutations associated with toxic and nontoxic goiter that have not been yet reported in Iraq, and most of them are detected among females (90 %) and adults age between 30 and 50 years old (80 %).

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The past year witnessed considerable turbulence in the Arab world-in this case, Syria, a lower middle-income country with a record of a strong public health infrastructure. This paper explores the current challenges facing its health system from reforms, civil strife and international sanctions all of which we argue have serious implications for population health. The health sector in Syria was little known, and until recently, it was well integrated to provide preventive and specialized care when needed. Regionally, it was one of the few countries ready and capable of addressing the challenges of demographic and epidemiologic transition with a long-standing emphasis on primary care and prevention, unlike most countries of the region. This context has changed dramatically through the recent implementation of reforms and the current civil war. Changes to financing, management and the delivery of health service placed access to services in jeopardy, but now, these are compounded by the destruction from an intractable and violent conflict and international sanctions. This paper explores some of the combined effects of reforms, conflict and sanctions on population health.

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The past 18 months have witnessed considerable turmoil in countries of the MENA region. The Syrian Arab Republic (SAR) is one such country, currently in the midst of a civil war. This report draws attention to some of the recent achievements of its health services, where, despite a dearth of published materials, the country achieved remarkable declines in maternal mortality and infant mortality rates. Its health sector now faces destruction from on-going violence compounded by economic sanctions that has affected access to health care, to medicines and to basic essentials as well as the destruction of infrastructure. This paper draws attention to the achievements of the country's health services and explores some of the consequences of conflict and of sanctions on population health. Readers need to be mindful that the situation on the ground in a civil war can alter on a daily basis. This is the case for Syria with much destruction of health facilities and increasing numbers of people killed and injured. We retain however our focus on the core theme of this paper which is on conflict and on sanctions.

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This descriptive study was designed to describe the patterns and determinants of maternity care among Syrian women living in Damascus. All 39 birth registers in 2 large provinces were used to recruit 500 mothers of healthy newborns. Mothers were interviewed in their homes using a semistructured questionnaire. Multivariate analysis of the determinants of the frequency of use of antenatal care showed the following variables were significant: urban residence and visit to antenatal care in the 1st trimester. The significant variables for an early visit to antenatal care were the woman's level of education; being pregnant with the 1st baby; and number of visits to antenatal care. Being young (age < 20 years) also correlated with early timing of the 1st antenatal visit.

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A community-based medical education programme at Damascus University was applied in a local setting from 2 to 12 July 2004 to assess the advantages and disadvantages. Three families and 10 medical students participated. The programme included teaching objectives, health education and approaches to application and evaluation. The design of the programme was appropriate for the community setting, but it needed a longer period to run and for contact between the students and the community. The students agreed with the structure of the programme and the role of the tutor and community, but were concerned about difficulties in implementation. Community members were enthusiastic about the programme.

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PURPOSE: To compare the safety and efficacy of single oral-dose azithromycin with a 7-week topical tetracycline ointment course in the treatment of active trachoma. METHODS: A total of 64 patients with active trachoma were selected randomly to receive azithromycin (20 mg/kg) in a single dose or topical tetracycline eye ointment for 6 weeks. Clinical assessments were made before and at 4, 8, 12, and 24 weeks after treatment. Conjunctival scrapings were obtained before and after 24 weeks after treatment and fixed for Giemsa and direct immunofluorescence staining. RESULTS: Trachoma resolved in 17 (63.3%) patients who received azithromycin compared with 19 (65.4%) who were treated with tetracycline ointment. There were no significant differences in treatment effect or baseline characteristics between the treatment groups. Both treatments were well tolerated, and no adverse events were noted. CONCLUSION: Single-dose azithromycin is as effective as a 6-week course of topical tetracycline ointment in the treatment of active trachoma. The findings may help establish high compliance in treating trachoma and could contribute to the control of trachoma worldwide.

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