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J Infect Dis ; 202(11): 1708-12, 2010 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-20977342

RESUMEN

The increased incidence and severity of Clostridium difficile infection (CDI) in older adults (age, ≥65 years) corresponds with the emergence of the BI/NAP1 strain, making elucidation of the host immune response extremely important. We therefore infected germ-free C57BL/6 mice aged 7-14 months with a BI/NAP1 strain and monitored the mice for response. Infected mice were moribund 48-72 h after infection and developed gross and histological cecitis and colitis and elevated concentrations of keratinocyte chemoattractant, interleukin 1ß, monocyte chemotactic protein 1, and granulocyte colony-stimulating factor and decreased levels of interferon γ, interleukin 12 p40, interleukin 12 p70, and interleukin 10 compared with controls. We conclude that aged, germ-free C57BL/6 mice are susceptible to fulminant CDI from a BI/NAP1 strain and represent a novel model to further elucidate the host immune response to acute CDI.


Asunto(s)
Clostridioides difficile/inmunología , Clostridioides difficile/patogenicidad , Enterocolitis Seudomembranosa/microbiología , Animales , Clostridioides difficile/clasificación , Colon/microbiología , Colon/patología , Modelos Animales de Enfermedad , Enterocolitis Seudomembranosa/inmunología , Enterocolitis Seudomembranosa/patología , Vida Libre de Gérmenes , Factor Estimulante de Colonias de Granulocitos/análisis , Interferón gamma/análisis , Interleucina-10/análisis , Interleucina-12/análisis , Sudunidad beta 1 del Receptor de Interleucina-12/análisis , Interleucina-1beta/análisis , Ratones , Ratones Endogámicos C57BL
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