RESUMEN
PURPOSE: To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). MATERIALS AND METHODS: FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated. RESULTS: Progressive gliomas had higher SUVmax (3.57⯱â¯1.47 vs. 1.60⯱â¯0.51; pâ¯=â¯0.003) and TBRmax (3.00⯱â¯1.12 vs. 1.36⯱â¯0.33; pâ¯=â¯0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmaxâ¯<â¯2.0 compared to tumors with TBRmaxâ¯>â¯2.0 (665⯱â¯32â¯days versus 220⯱â¯39â¯days; pâ¯<â¯0.001). CONCLUSION: FET-PET uptake might be associated with disease progression in adult BSG.
Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Tronco Encefálico/diagnóstico por imagen , Glioma/diagnóstico por imagen , Tomografía de Emisión de Positrones/métodos , Tirosina/análogos & derivados , Adolescente , Adulto , Progresión de la Enfermedad , Supervivencia sin Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tirosina/farmacología , Adulto JovenRESUMEN
We report a case of intracerebral cystic schwannoma in the temporal fossa manifested as a gradually worsening headache in a 49-years-old woman. Computed Tomography (CT) and magnetic resonance imaging (MRI) showed a left temporal partly cystic, partly solid mass. The preoperative diagnosis was astrocytoma or glioblastoma multiforme (GBM), but microscopic examination of the mass showed the characteristic pattern with cellular Antony A component. Immunohistochemically, the tumor was positive for S-100 protein. These findings are consistent with a schwannoma. Intracerebral schwannomas not related to cranial nerves are rare and most reported cases involved young patients.