RESUMEN
Single-photon emission CT of the heart was used to observe coronary blood flow and reveal the maximum perfusion region in patients with coronary heart disease (CHD) treated with beta-adrenoblockers and calcium channel blockers. Dynamic observation showed changes and redistribution of myocardial perfusion. Specific features of coronary blood flow were demonstrated depending on the therapeutic modality (beta-blocker metoprolol, calcium channel blocker amlodipine). Parameters of prognostic value were identified depending on the effectiveness of the agents used. This approach together with the traditional nosological one to the choice of CHD therapy permits to individualize the therapeutic influence depending on myocardial micriocirculatory features, such as the spread and depth of perfusion disturbances.
Asunto(s)
Amlodipino/administración & dosificación , Angina Estable , Metoprolol/administración & dosificación , Microcirculación/efectos de los fármacos , Antagonistas Adrenérgicos beta/administración & dosificación , Angina Estable/diagnóstico , Angina Estable/tratamiento farmacológico , Angina Estable/fisiopatología , Bloqueadores de los Canales de Calcio/administración & dosificación , Angiografía Coronaria , Vasos Coronarios/diagnóstico por imagen , Vasos Coronarios/efectos de los fármacos , Monitoreo de Drogas/métodos , Femenino , Pruebas de Función Cardíaca/métodos , Humanos , Masculino , Persona de Mediana Edad , Imagen de Perfusión Miocárdica/métodos , Pronóstico , Índice de Severidad de la Enfermedad , Tomografía Computarizada de Emisión de Fotón Único/métodos , Resultado del TratamientoRESUMEN
The authors presented the echocardiography and doppler sonography of aquanauts during the period of long-term effects of deep diving (to 500 m). According to the analysis of the given data the following was revealed: imperceptible atrium distensibility, left ventricular concentric remodeling without myocardial hypertrophy, saving of general and regional myocardial contractile function, left ventricular diastolic dysfunction grade 1, intact right ventricle, orthoarteriotony in pulmonary artery, change of size and distensibility of the aortic root. The authors came to conclusion that there are 2 different process in the structural ventricular remodeling during the period of long-term effects of deep diving--envolving myocardial consolidation and heart chamber dilation. These two processes is connected with temporary factor atypical for natural age dynamic. The aortic root has a atherosclerotic change and distensibility. There is no further dynamic distensibility. The abovementioned changes in heart and aorta can progress in aquanauts, which have too many dives. Patients in the study group haven't dived over the years, but nevertheless have the abovementioned changes.
Asunto(s)
Aorta , Buceo/efectos adversos , Ventrículos Cardíacos , Contracción Miocárdica , Exposición Profesional/efectos adversos , Arteria Pulmonar , Remodelación Ventricular , Adulto , Aorta/diagnóstico por imagen , Aorta/fisiopatología , Ventrículos Cardíacos/diagnóstico por imagen , Ventrículos Cardíacos/fisiopatología , Humanos , Masculino , Medicina Naval , Arteria Pulmonar/diagnóstico por imagen , Arteria Pulmonar/fisiopatología , UltrasonografíaRESUMEN
It is established that after the termination of deep saturation dives reorganization of respiratory system at navy aquanauts proceeds. This remodeling is specific, atypical for natural age dynamics.
Asunto(s)
Remodelación de las Vías Aéreas (Respiratorias) , Buceo/efectos adversos , Enfermedades Pulmonares/etiología , Personal Militar , Remodelación de las Vías Aéreas (Respiratorias)/fisiología , Buceo/fisiología , Humanos , Enfermedades Pulmonares/diagnóstico , Enfermedades Pulmonares/diagnóstico por imagen , Enfermedades Pulmonares/fisiopatología , Medicina Naval , Cintigrafía , Pruebas de Función Respiratoria , Factores de TiempoRESUMEN
Some new facts about the influence of different groups of drugs on myocardial perfusion were educed during the research. Educed facts conduce representation extension by matching the optimal therapy of ischemic heart disease. With the help of SPECT-scanning were educed myocardial blood flow, areas of maximal hypoperfusion and its influence on time pattern and redistribution of myocardial blood flow in patients receiving disease-modifying agents and statins. Some regularities of change of myocardial blood flow depending on applied group of drugs and peculiarities of influence of myocardial perfusion in certain time interval were revealed. Criteria with prognostic significance in prospective individual effectiveness of anti-ischemic drugs were pointed out. New approach, based on choice of anti-ischemic therapy depending on extent of influence on myocardial perfusion and also individual clinical and functional traits of patients, was applied.