RESUMEN

OBJECTIVE: To correlate the susceptibility of low-(LDL) and very-low-density lipoprotein to oxidation in vitro and the concentrations of serum antibodies against malondialdehyde-modified LDL and plasma vitamin E with the anthropometric and laboratory characteristics of obesity. RESEARCH METHODS AND PROCEDURES: A total of 75 nondiabetic, normotensive obese patients were assigned to one of four groups according to their body mass index (BMI): moderately obese (30 50 kg/m(2), n = 15). RESULTS: The oxidation lag time for LDL from patients with a BMI >or=35 kg/m(2) was shorter than that for LDL from non-obese controls (n = 13), whereas very-low-density lipoprotein oxidation lag times were not significantly different. The serum antibodies against modified LDL were similar in all groups, whereas the plasma vitamin E concentrations of obese patients were decreased (p

Asunto(s)

Peroxidación de Lípido , Obesidad/sangre , Vitamina E/sangre , Adulto , Consumo de Bebidas Alcohólicas , Anticuerpos/sangre , Constitución Corporal , Índice de Masa Corporal , Colesterol/sangre , Cobre/química , Femenino , Humanos , Lipoproteínas LDL/sangre , Lipoproteínas LDL/inmunología , Lipoproteínas VLDL/sangre , Masculino , Malondialdehído/farmacología , Persona de Mediana Edad , Obesidad Mórbida/sangre , Fumar , Triglicéridos/sangre