RESUMEN

To evaluate the effect of empiric intralipid infusion therapy on pregnancy outcomes for patients with unexplained recurrent implantation failure (RIF) undergoing intracytoplasmic sperm injection (ICSI). A total of 142 patients with a history of unexplained RIF (3 or more cycles) were included in this randomized controlled trial. Patients were randomized into two groups, study group (n = 71) and control group (n = 71). The study group received intralipid 20% infusion on the day of embryo transfer (ET) and a second dose on the day of pregnancy test. The clinical pregnancy rate in the study group was 36.6% (n = 26) compared to 28.2% (n = 20) in the control group (OR 1.47, CI 0.72-2.98, p = .282). The live birth rate in the study group was 18.3% (n = 13) and 14.1% (n = 10) in the control group (OR 1.37, CI 0.55-3.36, p=.49). No side effects of intralipid therapy were reported in the study period. There was improvement in the pregnancy rate among women with unexplained RIF who received empiric intralipid infusion therapy; however, this improvement did not reach statistical significance.

Asunto(s)

Implantación del Embrión/efectos de los fármacos , Transferencia de Embrión/métodos , Fosfolípidos/uso terapéutico , Aceite de Soja/uso terapéutico , Inyecciones de Esperma Intracitoplasmáticas/métodos , Adulto , Emulsiones/farmacología , Emulsiones/uso terapéutico , Femenino , Humanos , Fosfolípidos/farmacología , Embarazo , Resultado del Embarazo , Índice de Embarazo , Aceite de Soja/farmacología , Resultado del Tratamiento

RESUMEN

OBJECTIVE: To report a case of Fowler's syndrome after oocyte retrieval. DESIGN: Case report. SETTING: Tertiary referral center, King Fahad Medical City. PATIENTS: A 23-year-old nulligravida with polycystic ovarian syndrome and primary infertility underwent oocyte retrieval for intracytoplasmic sperm injection (ICSI), and developed Fowler's syndrome (FS). INTERVENTIONS: Intermittent self-catheterization, insertion of sacral neuromodulator (SNM). MAIN OUTCOME MEASURES: Restoration of normal voiding. RESULTS: Immediate resolution of patient's symptoms after installation of SNM. CONCLUSIONS: Fowler's syndrome, although rare, may occur post routine oocyte retrieval; Successful restoration of voiding and resolution of symptoms is possible with SNM installation in similar patients.