RESUMEN
Mycotoxins are naturally occurring food toxins worldwide that can cause serious health effects. The measurement of mycotoxin biomarkers in biological fluids is needed to assess individuals' exposure. The aim of this study was to investigate the incidence of mycotoxins in the Qatari population. Serum samples from 412 adults and urinary samples from 559 adults were analyzed for the presence of mycotoxin biomarkers. Multimycotoxin approaches have been applied, using liquid chromatography mass spectrometry methods. Samples were further analyzed for the oxidative stress markers and compared with regard to the incidence of mycotoxins. The presence of mycotoxins was identified in 37% of serum samples and in less than 20% of urine samples. It was found that 88% of positive of the samples were positive for only one mycotoxin, while 12% of positive samples had two or more mycotoxins. Trichothecenes and zearalenone metabolites were most commonly detected mycotoxins, followed by aflatoxins, roquefortine C and mycophenolic acid. The presence of mycotoxins was found to positively correlate with oxidative stress markers. The obtained results illustrate the importance of mycotoxin biomonitoring studies in humans and the need to elucidate the underlying mechanisms of mycotoxin-induced toxicity.
Asunto(s)
Monitoreo Biológico , Contaminación de Alimentos , Micotoxinas/sangre , Micotoxinas/orina , Estrés Oxidativo , Adulto , Biomarcadores/sangre , Biomarcadores/orina , Carga Corporal (Radioterapia) , Cromatografía Líquida de Alta Presión , Daño del ADN , Femenino , Humanos , Masculino , Persona de Mediana Edad , Qatar , Espectrometría de Masa por Ionización de Electrospray , Espectrometría de Masas en TándemRESUMEN
Mycotoxins are secondary metabolites produced by different fungal spices and are found in diverse agricultural crops worldwide; they pose a severe threat to public health. Mycotoxins can cause either acute or chronic symptoms, depending on the type and dose of mycotoxin one has been exposed to. Thus, a continuous monitoring of mycotoxins is needed. Since the discovery of mycotoxins, numerous countries, including the Gulf Cooperation Council (GCC) countries, have established mycotoxin-specific regulations for feed and food. Although a number of studies in GCC countries have investigated the presence of mycotoxins, till date, there are no reviews focusing on the mycotoxin contamination of the food and feed from this region. This review is the first study to present an up-to-date overview of the occurrence of mycotoxins in feed and food in the GCC countries and to discuss the techniques used for mycotoxin analysis.
Asunto(s)
Alimentación Animal/análisis , Contaminación de Alimentos/análisis , Micotoxinas/análisis , Análisis de los Alimentos/métodos , Medio OrienteRESUMEN
Human exposure to mycotoxins occurs mostly through dietary intake, although exposure through dermal and inhalation routes has also been shown. Depending on the type of mycotoxins, the applied dose and duration of exposure, a particular toxin can cause either chronic or acute illnesses such as kidney failure and cancer. Thus, understanding the biotransformation of mycotoxins and identification of reliable biomarkers in the human body is important for accurate risk assessment of mycotoxin exposure. This review provides a comprehensive overview of worldwide aflatoxins, fumonisins, ochratoxin, zearalenone and deoxynivalenol mycotoxin biomonitoring studies reported in the last 18 years. The studies performed in Africa, Europe, Asia and America are based on the measurement of a limited number of mycotoxin biomarkers and do not provide a comprehensive risk assessment of the mycotoxin exposure. Although the findings represent a small segment of a much larger health risk of mycotoxins exposure, it is acknowledged that a multianalyte approach covering bioconjugated and other metabolites of most often occurring mycotoxins would better reflect the extent of the global exposure problems with these highly toxic compounds.