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OBJECTIVES: To identify the dysregulated functional miRNAs, miRNA-16, miRNA-143, and miRNA-200 as potential biomarkers of cerebral aneurysms(CAs) to aid in diagnosis and prognosis. METHODS: This is a prospective case-control study conducted among patients with CA. All patients' computed tomography angiography (CTA) and interventional angiogram were assessed and studied. The miRNAs were isolated and quantified from peripheral blood samples and the expression profiling was done using TaqMan chemistry on Real-Time PCR. RESULTS: A total of 37 samples were included. Three cases had double aneurysms and 10 cases presented with aneurysmal rupture. miRNA-16, miRNA-143, and miRNA-200 were upregulated with an absolute fold-change of >8 in the CA group in comparison to controls (p<0.05). miRNA-200 showed double expression in patients with single aneurysm. A statically significant increase was observed in the expression of miRNA-143 in patients who had an aneurysmal rupture with p<0.05. Diabetic patients showed an obvious increase in miRNA-200 (13.03 folds) and miRNA-16 (26.82 folds) expression. Also, there was a notable elevation in miRNA-16, miRNA-143, and miRNA-200 in patients who had hypertension in comparison to those who did not. CONCLUSION: miRNA-16, miRNA-143, and miRNA-200 showed statically significant higher expression among cases with cerebral aneurysms in comparison to controls. Thus, these preliminary results of miRNAs biomarkers are promising future tool to be used for aneurysmal screening.

Asunto(s)

Aneurisma Intracraneal , MicroARNs , Humanos , MicroARNs/genética , Aneurisma Intracraneal/diagnóstico por imagen , Aneurisma Intracraneal/genética , Pronóstico , Estudios de Casos y Controles , Biomarcadores

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Objectives: The quality of health care is individually and subjectively reflected through patients' level of satisfaction, as well as the optimality and effectiveness of the provided postoperative pain management. The provision of postanesthesia care unit (PACU) service in hospitals has led to overall positive outcomes, in addition to the enhancement of patients' satisfaction with the provided pain management service. This study assessed patients' level of satisfaction with PACU service at a university hospital and discussed different factors that might have contributed to the level of satisfaction. Methods: A prospective cross-sectional study was carried out among patients after being discharged from PACU. The study took place at King Fahad Hospital of the University in Al Khobar, KSA between November 2021 and February 2022. The data were collected using a three-section predesigned questionnaire. Results: Two hundred patients were included in this study. Nearly all patients (95.5%) were satisfied with the provided pain management service. Almost all patients (99.5%) indicated that the PACU staff was courteous and professional during the entire pain management service. More patients complained about pain before using analgesia and this difference was statistically significant (Z = 8.642; p < 0.001). The satisfaction rate was significantly higher in the older age group (>45 years) (Z = 2.114; p = 0.035), in patients with American Society of Anesthesiology (ASA) 3 physical status (H = 13.130; p = 0.001), and those with a previous surgical history (Z = 2.139; p = 0.032). Conclusion: This study concluded that the level of patients' satisfaction with PACU service was high, and established a statistically significant association with age, ASA score, and previous surgical history. Healthcare providers should consider patient education and effective communication to increase patients' satisfaction level and improve the overall quality of care.

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Aims: The aim of this study was to evaluate the impact of domestic violence on depression among females' students of Imam Abdulrahman bin Faisal University in the Kingdom of Saudi Arabia. Settings and Design: A cross-sectional study conducted from 2019 to 2020. Methods and Material: An electronic questionnaire containing biographical data, 2 nd edition of Beck Depression Inventory (BDI), and The NorVold Abuse Questionnaire (NorAQ) was sent to the participants. Statistical Analysis Used: Data were analyzed using SPSS version 24 with a statistical significance set at P < 0.05. Tests of significance measured using independent t test and Chi-square test. Results: The study included 214 female medical students and 11 interns aged 18 to 26 with a mean of 20.66 ± 1.725 years. Most women (92.4%) were single, and the highest responders (30.2%) were second-year students. Based on The NorVold Abuse Questionnaire (NorAQ), the prevalence of violence was 56.9%. The most common form of violence was emotional abuse (50.2%) and the highest combined types of abuse were emotional and physical abuse (14.7%). Based on BDI scale, the prevalence of depression amongst our sample was 32.9%; it was mild in 14.2%, moderate in 15.6% and severe in 3.1%. None of the types of abuse were significantly associated with depression. However, severe depression was highest amongst students/interns with history of emotional or sexual violence. Conclusion: More than half of the participants were subjected to domestic abuse throughout their lives. Emotional abuse was the commonest type followed by physical, sexual, and healthcare abuses, respectively. However, the present study demonstrated no significant association between abuse and depression.