RESUMEN

The pharmacokinetics and metabolism of meloxicam was studied in camels (Camelus dromedarus) (n = 6) following intravenous (i.v.) administration of a dose of 0.6 mg·kg/body weight. The results obtained (mean ± SD) were as follows: the terminal elimination half-life (t(1/2ß) ) was 40.2 ± 16.8 h and total body clearance (Cl(T) ) was 1.94 ± 0.66 mL·kg/h. The volume of distribution at steady state (V(SS)) was 92.8 ± 13.7 mL/kg. One metabolite of meloxicam was tentatively identified as methylhydroxy meloxicam. Meloxicam and metabolite were excreted unconjugated in urine. Meloxicam could be detected in plasma 10 days following i.v. administration in camels using a sensitive liquid chromatography tandem mass spectrometry (LC/MS/MS) method.

Asunto(s)

Antiinflamatorios no Esteroideos/sangre , Antiinflamatorios no Esteroideos/farmacocinética , Camelus/sangre , Tiazinas/sangre , Tiazinas/farmacocinética , Tiazoles/sangre , Tiazoles/farmacocinética , Animales , Antiinflamatorios no Esteroideos/metabolismo , Antiinflamatorios no Esteroideos/orina , Área Bajo la Curva , Camelus/orina , Cromatografía Liquida/veterinaria , Residuos de Medicamentos , Semivida , Inyecciones Intravenosas , Masculino , Meloxicam , Espectrometría de Masas en Tándem/veterinaria , Tiazinas/metabolismo , Tiazinas/orina , Tiazoles/metabolismo , Tiazoles/orina