RESUMEN
This study aims to optimize the performance of CrN coatings deposited on WC cutting tools for machining Ti6Al4V alloy, where the formation of built-up edge (BUE) is a prevalent and critical issue. In-house CrN coatings were developed using the PVD (Physical Vapor Deposition) process, with variations in deposition parameters including nitrogen gas pressure, bias voltage, and coating thickness. A comprehensive experimental approach encompassing deposition, characterization, and machining performance evaluation was employed to identify the optimal deposition conditions. The results indicated that CrN coatings deposited at a nitrogen gas pressure of 4 Pa, a bias voltage of -50 V, and a thickness of 1.81 µm exhibited superior performance, significantly reducing BUE formation and tool wear. These optimized coatings demonstrated enhanced properties, such as a higher elastic modulus and a lower coefficient of friction, which contributed to improved tool life and machining performance. Comparative studies with commercial CrN coatings revealed that the in-house developed coatings outperformed the commercial variants by approximately 65% in tool life, owing to their superior mechanical properties and reduced friction. This research highlights the potential of tailored CrN coatings for advanced machining applications and emphasizes the importance of optimizing deposition parameters to achieve high-performance tool coatings.
RESUMEN
Lung cancer is the primary cause of cancer related deaths worldwide. Limited therapeutic options and resistance to existing drugs are the major hindrances to the clinical success of this cancer. In the past decade, several studies showed the role of microRNA (miRNA) driven cell cycle regulation in lung cancer progression. Therefore, these small nucleotide molecules could be utilized as promising tools in lung cancer therapy. In this review, we highlighted the recent advancements in lung cancer therapy using cell cycle linked miRNAs. By highlighting the roles of the specific cell cycle core regulators affiliated miRNAs in lung cancer, we further outlined how these miRNAs can be explored in early diagnosis and treatment strategies to prevent lung cancer. With the provided information from our review, more medical efforts can ensure a potential breakthrough in miRNA-based lung cancer therapy.
RESUMEN
Chromium (Cr) is a trace element and plays a significant role in fish nutrition and physiology. An experiment was designed to know the effects of Cr addition in the diets to growth and feed utilization in striped catfish (Pangasianodon hypophthalmus). Four diets with Cr (0, 2, 4, and 8 mg kg-1) were fed to striped catfish in aquaria with triplicate groups for 60 days. Survival, growth parameters (weight gain, WG; %WG; specific growth rate, SGR), and feed utilization (feed intake, FI; feed efficiency, FE; protein efficiency ratio, PER; feed conversion ratio, FCR) were calculated at the end of the feeding trial. Several hemato-biochemical parameters, such as hemoglobin (Hb), red blood cell (RBC), white blood cell (WBC) and glucose level, and frequency of micronucleus (MN) formation in erythrocytes, were analyzed. The growth parameters (WG, %WG, and SGR) and feed utilization (FE and PER) increased significantly in the fish fed with 2 and 4 mg kg-1 Cr supplemented diets. On the other hand, the growth parameters suppressed in the fish fed with 8 mg kg-1 Cr-based diet. The polynomial regression analysis based on WG showed that 2.82 mg kg-1 Cr supplementation in the diet is optimum for the tested fish species. The values of Hb (g/dL), RBC (×106/mm3) and blood glucose (mg/dL) significantly decreased in the fish fed with the highest (8 mg kg-1) Cr-based feed. Conversely, MN frequency was significantly increased in the fish fed with 8 mg kg-1 Cr-based diet. Overall, 2.82 mg Cr kg-1 can be added to the diets of striped catfish for its better growth with maximum utilization of feed.