RESUMEN

Beta-Amyloid peptide (Abeta) is the main protein component of neuritic plaques in the brain of patients of Alzheimer's disease (AD), and its neurotoxicity would be exposed by the formation of aggregates. The aggregation inhibitors composed of an Abeta recognition element (KLVFF) and a hydrophilic moiety are evaluated by a novel fluorescence assay. These compounds inhibit growth of the model aggregates on the KLVFF immobilized surface. In addition, some compounds also possess disrupting activities of preformed aggregates. These compounds could be a key candidate for therapeutic drugs for AD by their novel molecular mechanisms.

Asunto(s)

Péptidos beta-Amiloides/antagonistas & inhibidores , Péptidos beta-Amiloides/química , Oligopéptidos/farmacología , Secuencia de Aminoácidos , Péptidos beta-Amiloides/toxicidad , Unión Competitiva , Colorantes Fluorescentes/química , Humanos , Interacciones Hidrofóbicas e Hidrofílicas , Modelos Químicos , Datos de Secuencia Molecular , Oligopéptidos/síntesis química , Oligopéptidos/química , Unión Proteica , Espectrometría de Fluorescencia