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Both diabetes and peripheral arterial disease (PAD) have complex interactions with COVID-19. PAD is one of the most important underlying factors in the development of diabetic foot. The COVID-19 pandemic has also caused an increase in cardiovascular complications in those with chronic diseases, including diabetics, due to both the thrombophilic course of the viral disease and the lockdown measures applied for prevention. Since both COVID-19 and diabetes mellitus predispose to thrombosis, PAD is likely to have a more severe course in diabetic patients with COVID-19. The aim of our study is to discuss the complications, prophylaxis, and treatment of PAD, which is a serious complication of diabetes, during the pandemic period.
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This study was conducted to evaluate the wound-healing activities of a Cannabis sativa L. plant extract and cannabidiol on incision wounds. An incision was created and sutured in rats under anaesthesia. Routine wound care procedures were applied for 10 days, followed by histological wound examinations. The cellular bioactivities of the hemp extract and CBD were assessed for MCP-1, EGF, BFGF, IL-8, and COL-1 using ELISA on the rat skin wound healing activity. A one-way ANOVA was used for the data analysis. The EGF values in the plasma were similar in the povidone-iodine, hemp seed oil, and hemp essential oil groups (P > 0.05). However, the EGF levels were lower in the CBD group compared to the other groups (P < 0.001, P < 0.005). The MCP-1 values in the hemp seed oil, hemp essential oil, and CBD were similar (P > 0.05), whereas povidone iodine exhibited lower MCP-1 levels compared to the other groups (P < 0.001, P < 0.005). It was determined that the plasma BFGF, IL-8, and COL 1 values of the groups were similar (P > 0.05). To our knowledge, this study is the first to evaluate the effects of CBD, seed oil, and hemp leaf extract on incision wound healing. It demonstrates that hemp extract holds greater potential benefits for wound healing compared to CBD.
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INTRODUCTION: In this study, it was aimed to investigate the effect of thymoquinone (TQ) on oxidative stress and apolipoprotein E (ApoE) in an experimental Alzheimer's model created with AlCl3 and D-galactose in rats. METHODS: Thirty-six Wistar Albino male rats saline group (Group 1), aluminum chloride (AlCl3) + D-galactose (D-Gal) group (Group 2), AlCl3 + D-Gal + TQ group (Group 3) were divided into 3 groups. The study was completed with 33 rats. Group 1 was given saline intraperitoneally (i.p) for 28 days. 2nd group; D-Gal at a dose of 60 mg/kg/day and AlCl3 at a dose of 40 mg/kg/day were given i.p. daily for 28 days. 3rd group; D-Gal at a dose of 60 mg/kg/day and AlCl3 at a dose of 40 mg/kg/day were given i.p. daily for 28 days. Group 3 rats were given 20 mg/kg/day TQ in corn oil by gavage for 14 days. Malonyl dialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAS), total oxidant capacity (TOS), glutathione peroxidase (GsH-Px), and ApoE levels were determined in the blood and brain tissues of rats in all three groups. One-way ANOVA test was used in the statistical analysis of the data. RESULTS: Means of TAS, TOS, GSH-Px, SOD, MDA, and ApoE in blood and brain tissue of all three groups (excluding ApoE in brain tissue) were different from each other and this difference was statistically significant (p < 0.05). CONCLUSION: In this study, TQ, it was determined that all oxidative stress parameters examined had positively affected and decreased blood tissue ApoE levels. TQ can be used as an antioxidant and curative in Alzheimer's disease.
Asunto(s)
Enfermedad de Alzheimer , Antioxidantes , Humanos , Animales , Ratas , Cloruro de Aluminio/farmacología , Antioxidantes/farmacología , Galactosa/farmacología , Enfermedad de Alzheimer/tratamiento farmacológico , Ratas Wistar , Estrés Oxidativo , Superóxido Dismutasa/metabolismo , Superóxido Dismutasa/farmacología , Apolipoproteínas ERESUMEN
AIM: The aim of this study was to determine the health problems experienced by young adults after the COVID-19 vaccine. METHOD: This study is a quantitative and descriptive study and was completed with 590 undergraduate students studying at a state university in Central Anatolia in the spring semester of the 2021-2022 academic year. The data were collected by the researcher through a one-to-one interview with the students and a questionnaire prepared in line with the literature. Number, percentage and chi-square tests were used in the analysis of the data. RESULTS: A total of 81.4% of the students participating in the study had the BioNTech-Pfizer vaccine. A total of 67.3% of them had two doses of COVID-19 vaccine, 35.9% of the vaccinated students experienced some health problems in the days following the vaccination, and the most common health problems were fatigue, a cough, sleep disturbance, psychological discomfort, a heart ache feeling and sweating. Most of the post-vaccine health problems lasted for 2 days, 3.7% of the participants were diagnosed with hypertension, 2.7% were diagnosed with diabetes mellitus and 10.52% of the female participants went to the doctor due to menstrual irregularity and received treatment. It was determined that 12.2% of the vaccinated students gained weight after vaccination and 63.89% of those who gained weight attributed this to increased appetite, 9.2% continued to have a cough and 9.2% used herbal products. CONCLUSION: It was determined that one out of every three young adults experienced a health problem after the COVID-19 vaccine. It is recommended that studies be conducted in different sample groups.
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Context: Pregnancy yoga is a modified version of yoga for pregnant women, and it aims to reduce pregnancy-related symptoms, such as insomnia, low back pain, tiredness, constipation, leg cramps, and shortness of breath. Objective: The study aimed to identify the experiences and expectations of pregnant women related to the practice of yoga. Method: The research team conducted a qualitative study. Setting: The study took place at the antenatal clinic of a public hospital in the Central Anatolia region of Turkey. Participants: The participants were 24 pregnant women at the clinic. Intervention: The study included an intervention group that performed yoga and received routine antenatal care; however, no control groups were used. Each yoga intervention was held for approximately 40-45 minutes, with yoga asana periods lasting 30 minutes. The pregnant women were expected to participate in yoga practice twice a week on a regular basis for 8 weeks. Outcome Measures: Data were collected through semi-structured interviews. The interviews were recorded and transcribed verbatim and thematic analysis was performed. Results: Four major themes emerged: (1) perceptions about pregnancy, (2) management of pregnancy symptoms, (3) prenatal attachment, and (4) birth perceptions. According to participants, the benefits of yoga practice were management of pregnancy symptoms, increased prenatal attachment, a positive perception of the birth, natural-birth beliefs, and management of fear and pain during birth. Conclusions: The participants reported barriers to performing yoga; however, they also said that they would try pregnancy yoga if they were encouraged by healthcare professionals. Also, the participants stated that pregnancy yoga practice should be made a part of antenatal education to facilitate participation.