RESUMEN
A treatment modality employing radiotherapy with subsequent hyperglycemia induction was evolved in experiments on mice and then clinically tested in 32 cases of inoperable locally--extensive primary and recurrent cancer of the rectum. A 50% regression of tumor was registered in 14 (43.0%) out of 32 patients treated with radiotherapy in combination with hyperglycemia. Similar degree of regression was observed only in 6 (15.0%) out of 40 patients who received the same radiation treatment unaccompanied by hyperglycemia. The difference was statistically significant. No untoward side--effects developed. The results are encouraging and seem to open up new vistas of clinical research.
Asunto(s)
Adenocarcinoma/radioterapia , Glucemia/fisiología , Glucosa , Fármacos Sensibilizantes a Radiaciones , Neoplasias del Recto/radioterapia , Adenocarcinoma/sangre , Adulto , Anciano , Animales , Carcinoma de Ehrlich/radioterapia , Terapia Combinada , Humanos , Masculino , Ratones , Persona de Mediana Edad , Neoplasias del Recto/sangreRESUMEN
The paper deals with an analysis of the results of treatment of 12 breast cancer patients receiving preoperative radiation and chemotherapy and in whom short-term hyperglycemia was simultaneously induced. The peculiarities of the said modality and advantages offered by its application are discussed. The cases given the same treatment unaccompanied by hyperglycemia were in control. Since short-term hyperglycemia as a component of complex treatment of breast cancer resulted in a higher effectiveness of the latter, it merits attention and further studies.