RESUMEN

The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8+/-25.7 nM).

Asunto(s)

Dinoprost/farmacología , Oxitócicos/farmacología , Oxitocina/farmacología , Agregación Plaquetaria/efectos de los fármacos , Adenosina Difosfato/farmacología , Dinoprost/efectos adversos , Femenino , Humanos , Técnicas In Vitro , Trabajo de Parto/sangre , Oxitócicos/efectos adversos , Oxitocina/efectos adversos , Activación Plaquetaria/efectos de los fármacos , Embarazo , Hemorragia Uterina/etiología , Hemorragia Uterina/prevención & control