RESUMEN
The accumulation rate and velocity of 99mTc-hydroxymethylene diphosphonate (99mTc-HMDP) in hip joints were determined within four minutes after a bolus of injection of 99mTc-HMDP in the patients with hip joint disorders. There exist a significant relationship between accumulation velocity of 99mTc-HMDP in the affected joint and serum osteocalcin in the patients with eight cases of degenerative osteoarthropathy and six cases of femoral necrosis. This result indicates that the accumulation velocity of 99mTc-HMDP in the affected joint is likely to become a marker of bone turnover in hip joint disorder.
Asunto(s)
Necrosis de la Cabeza Femoral/diagnóstico por imagen , Osteoartritis de la Cadera/diagnóstico por imagen , Medronato de Tecnecio Tc 99m/análogos & derivados , Adulto , Anciano , Proteínas de Unión al Calcio/sangre , Femenino , Necrosis de la Cabeza Femoral/metabolismo , Articulación de la Cadera/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Osteoartritis de la Cadera/metabolismo , Osteocalcina , Cintigrafía , Medronato de Tecnecio Tc 99m/farmacocinéticaRESUMEN
The dementia patients with central nervous or neuro-cerebro vascular disorders seemed to be decreased serum Mg due to abnormal Mg uptake in diet. An increment of PTH level was paralleled with a rise of serum Mg and hypomagnesemic group was shown to have a lower PTH level in these patients. Our results suggested that secondary hypoparathyroidism was likely to be induced by normo-calcemic hypomagnesemia.
Asunto(s)
Demencia/sangre , Magnesio/sangre , Hormona Paratiroidea/sangre , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
This study was carried out to investigate effects of drugs treated in the elderly osteoporotic patients on measurements of carboxy terminal, mid-region and intact PTH, by using the various kinds of PTH kits. The drugs such as 1 alpha(OH)D3, calcitonin and so on, in the treatment of osteoporotic patients, was brought about no significant inter-relationships among carboxy terminal, mid-region and intact PTH in sera of the elderly osteoporotic patients with serum high alkaline phosphatase activity.
Asunto(s)
Fosfatasa Alcalina/sangre , Osteoporosis/sangre , Hormona Paratiroidea/sangre , Anciano , Femenino , Humanos , Hidroxicolecalciferoles/farmacología , Hidroxicolecalciferoles/uso terapéutico , MasculinoRESUMEN
This study focussed on elucidating difference of blood PTH levels, by employing the various kinds of PTH kits. We carried out the measurements of PTH levels in sera of the hemodialysis patients with renal insufficiency presumably inactivated PTH degradative regulation in kidney. Our results showed the remarkable significant relationships among blood PTH levels of carboxyl and mid-region PTH and intact PTH in hemodialysis patients and was deduced that the difference of PTH levels by using various kinds of PTH kits was responsible of PTH cleavage effect in the kidney.
Asunto(s)
Fallo Renal Crónico/sangre , Hormona Paratiroidea/sangre , Juego de Reactivos para Diagnóstico , Diálisis Renal , Adulto , Anciano , Femenino , Humanos , Fallo Renal Crónico/terapia , Masculino , Persona de Mediana Edad , RadioinmunoensayoRESUMEN
In order to evaluate the gastric emptying and postprandial mixing of bile with food, the scintigraphies of hepatobiliary and gastrointestinal tracts by using three different kinds of radioisotopes were performed simultaneously (99mTc-E.HIDA for hepatobiliary scintigraphy, 111In-DTPA containing orange juice and 131I-albumin containing scrambled egg for gastrointestinal scintigraphy). This method was available for observation of gastric emptying of liquid and solid foods and also examination of the mixing effect of bile and food quantitatively.
Asunto(s)
Bilis/fisiología , Vaciamiento Gástrico , Iminoácidos , Compuestos Organometálicos , Ácido Pentético , Albúmina Sérica Radioyodada , Humanos , Lidofenina de Tecnecio Tc 99mRESUMEN
In order to evaluate the influences of serum PTH assay in the various concentrations of serum calcium, we divided into three groups which serum calcium had below 8.0 mg/dl, 8.2 mg/dl to 9.8 mg/dl and above 10.0 mg/dl at random samples and assayed PTH in serum sample, using various kits of PTH assay obtained from commercial sources. Our results suggested that the measurement of serum PTH influenced by the concentration of serum calcium and therefore, should be taken an attention of serum calcium in each sample.
Asunto(s)
Calcio/sangre , Hormona Paratiroidea/sangre , Radioinmunoensayo/métodos , Juego de Reactivos para Diagnóstico , Calcio/fisiología , HumanosRESUMEN
This study was focussed our attention on the measurement within the upper physiological level of human serum parathyroid hormone (PTH), using kits of human PTH 53-84. This assay kit was able to detect serum PTH in sera with subtle changes of serum calcium concentrations before and after short term exercise. These serum PTH levels before and after exercise seemed to be changed within the upper physiological levels of PTH. Thus, this study suggested that the assay kit was likely to become a useful tool of the measurement of the physiological level of serum PTH in humans.
Asunto(s)
Calcio/metabolismo , Hormona Paratiroidea/sangre , Esfuerzo Físico , Radioinmunoensayo/métodos , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Juego de Reactivos para Diagnóstico/normasRESUMEN
Clinical utility of determination of serum deoxythymidine kinase (TK) activity is described. It is well known that elevated TK level is observed in leukemia and other malignant diseases, or some viral infectious diseases. The TK activity was assayed on normal subjects, hepatitis B virus (HBV) positive liver diseases and various cancer by a newly developed high sensitive method, radio enzyme assay (REA) utilizing 125I-iododeoxyuridine as the substrate. Measurement of TK activity by the REA is revealed to be useful for "the marker of DNA metabolism anomaly" in leukemia, etc.