RESUMEN
Malignant melanoma of the rectum comprises 0.5%-4% of all anorectal cancers. Malignant melanoma of the rectum is exceptionally a rare disease. It commonly affects the fifth or sixth decade, with nonspecific symptoms such as rectal bleeding or anal pain. After skin and retina, anorectum is the third common site for malignant melanoma. Proper diagnosis is difficult in the majority of cases due to lack of pigmentation and amelanotic histological appearance. Prognosis is very poor with a median survival of 24 months and five-year survival of 10%-15%. Anorectal malignant melanomas disseminate along the submucosal planes, therefore complete resection at the time of diagnosis is usually not possible.
RESUMEN
Progeria is a rare genetic disease that manifests with progressive symptoms eventually leading to death. The only current treatment protocol of such patients is symptom based. However, recent trials are testing potential and promising drugs to treat the underlying genetic mutation and increase life expectancy of such patients.
RESUMEN
A man of 30 years, admitted in Neurology unit of Mymensingh Medical College Hospital with weakness of all four limbs for 4 weeks which was of gradual onset and progressive. He had no difficulty in vision, swallowing & speech. He had no disturbances of sensation, bowel & bladder functions. There was no preceding history of gastrointestinal or upper respiratory tract infection or vaccination. General examination was normal except the presence of hypertension detected two months before the onset of current illness. All cranial nerve functions were intact. Muscle power was grade 4 in all limbs and the reflexes were absent. All modalities of sensation and coordination were normal. Cerebro-spinal fluid (CSF) study revealed protein-cell dissociation. Electro physiologic findings were consistent with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). The patient was treated with prednisolone 60mg/day for two months with improvement of muscle power. The steroid was reduced gradually and then maintained 20mg/day without any relapse.