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Introduction Tympanoplasty is the main treatment of mucosal type of chronic suppurative otitis media. Objective The aim of the present study was to compare clinical outcomes in terms of healing and audiological outcomes of two groups. The authors used single layer graft (perichondrium with cartilage island) graft in one group and double layer grafts (perichondrium cartilage island composite plus temporalis fascia) were used in the second group. Methods Forty patients complained of chronic suppurative otitis media safe type with subtotal perforation subdivided into two groups. The first group author used single-layer perichondrium with cartilage island graft (composite graft) while in the second group authors used double graft in the form of perichondrium/cartilage island (composite graft) plus temporalis fascia. Results There was no significant difference in the mean Air bone gap (ABG) between pre- and post-operative audiometry in subjects who had single layer tympanoplasty. There was a significant difference in the mean ABG between pre- and postoperative audiometry in subjects who had double layer tympanoplasty. There was a significant difference in in the mean ABG differences between subjects who had single layer tympanoplasty and double layer tympanoplasty. Also, there was a significant difference in the healing of the tympanic membrane between subjects who had single layer tympanoplasty and double layer tympanoplasty. Conclusion Tympanoplasty by double graft (temporalis fascia and tragal cartilage/perichondrium) achieved a considerable improvement in healing of the tympanic membrane ™ with lower risk for residual perforation or graft rejection.
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Abstract Introduction Tympanoplasty is the main treatment of mucosal type of chronic suppurative otitis media. Objective The aim of the present study was to compare clinical outcomes in terms of healing and audiological outcomes of two groups. The authors used single layer graft (perichondrium with cartilage island) graft in one group and double layer grafts (perichondrium cartilage island composite plus temporalis fascia) were used in the second group. Methods Forty patients complained of chronic suppurative otitis media safe type with subtotal perforation subdivided into two groups. The first group author used single-layer perichondrium with cartilage island graft (composite graft) while in the second group authors used double graft in the form of perichondrium/cartilage island (composite graft) plus temporalis fascia. Results There was no significant difference in the mean Air bone gap (ABG) between pre- and post-operative audiometry in subjects who had single layer tympanoplasty. There was a significant difference in the mean ABG between pre- and postoperative audiometry in subjects who had double layer tympanoplasty. There was a significant difference in in the mean ABG differences between subjects who had single layer tympanoplasty and double layer tympanoplasty. Also, there was a significant difference in the healing of the tympanic membrane between subjects who had single layer tympanoplasty and double layer tympanoplasty. Conclusion Tympanoplasty by double graft (temporalis fascia and tragal cartilage/perichondrium) achieved a considerable improvement in healing of the tympanic membrane ™ with lower risk for residual perforation or graft rejection.
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SUMMARY: Osteoporosis is a bone condition marked by a loss of bone mass and a disruption of bone microarchitecture. Men lose bone density as they age, resulting in brittle bones. The loss of free testosterone is one of the key factors. The objective of present study was to evaluate Allolobophora caliginosa extract (AcE) for its anti-osteoporotic and antiapoptotic activity in orchiotomized rat model at two different dose levels. Twenty eight male rats were divided into two groups. The first group represented sham operated rats while the second group underwent bilateral orchidectomy (OCX). After one week of recovery from orchidectomy surgery, the second group was randomly subdivided into 3 subgroups. The first OCX subgroup was administered orally distilled water daily for 10 weeks. The other two OCX subgroups were administered AcE (100 or200 mg/kg body weight/day) orally for 10 weeks. Orchiectomy induces remarkable loss of the cortical as well as trabecular bone loss; which, could be counterbalanced by Allolobophora caliginosa extract (AcE) that prevented cortical as well as trabecular bone loss. Allolobophora caliginosa extract (AcE) at Dose 200 mg/kg/day was found to be effective at a highly significant level in osteoporotic bone, as determined by histological images and immunohistochemical study, where Dose (100 mg/kg/day) was found to be moderately significant.In the present study, it is suggested that AcE may inhibit steroid-induced osteoblasts apoptosis, potentially via upregulation of Bcl-2 and downregulation of caspase-3. Allolobophora caliginosa extract demonstrates anti-apoptotic and anti-oxidant properties. Therefore, AcE may be used for the prevention of steroid-induced bone damage.
RESUMEN: La osteoporosis es una afección ósea caracterizada por una pérdida de masa ósea y una alteración de la microarquitectura ósea. Los hombres pierden densidad ósea a medida que envejecen, lo que resulta en huesos quebradizos. La pérdida de testosterona libre es factor clave en este proceso. El objetivo del presente estudio fue evaluar el extracto de Allolobophora caliginosa (AcE) debido a su actividad antiosteoporótica y antiapoptótica en un modelo de rata orquiectomizadas con dos niveles de dosis diferentes. Se dividieron veintiocho ratas macho en dos grupos. El primer grupo incluyó ratas con operación simulada, mientras que el segundo grupo se sometió a orquidectomía bilateral (OCX). Después de una semana de recuperación de la orquidectomía, el segundo grupo fue subdividido en 3 subgrupos. Al primer subgrupo de OCX se administró diariamente agua destilada por vía oral durante 10 semanas. Los otros dos subgrupos de OCX se administraron por vía oral AcE (100 o 200 mg / kg de peso corporal / día) durante 10 semanas. La orquidectomía induce una pérdida notable del hueso cortical y trabecular; el cual podría ser contrarrestado por el extracto de Allolobophora caliginosa (AcE) que previno la pérdida de hueso tanto cortical como trabecular visualizado en imágenes histológicas y estudio inmuno- histoquímico, donde se encontró que la dosis (100 mg / kg / día) era moderadamente significativa. En el presente estudio, se sugiere que la AcE puede inhibir la apoptosis de los osteoblastos inducida por esteroides, potencialmente a través de la regulación al alza de Bcl 2 y la regulación a la baja de caspasa 3. El extracto de Allolobophora caliginosa demuestra propiedades anti apoptóticas y antioxidantes. Por lo tanto, AcE puede usarse para la prevención del daño óseo inducido por esteroides.
Asunto(s)
Animales , Masculino , Ratas , Oligoquetos , Osteoporosis/tratamiento farmacológico , Extractos de Tejidos/administración & dosificación , Orquiectomía/efectos adversos , Osteoporosis/etiología , Osteoporosis/prevención & control , Extractos de Tejidos/farmacología , Huesos/efectos de los fármacos , Inmunohistoquímica , Ratas Wistar , Apoptosis/efectos de los fármacosRESUMEN
ABSTRACT Studies related with the storage of peach fruits have received great relevance in Egypt. In this study, the effect of pre-harvest sprays of calcium chloride and chitosan, separately and in combination, on quality attributes and storability of peach fruits stored at 0±1 °C was studied. 'Early Swelling' peach trees were sprayed twice with 1% or 2% calcium chloride. The first spraying was at pea stage, while the second one was performed at 10 days before harvesting. Chitosan sprays were performed at 0.5 or 1%, alone or in combination with 1 and 2% calcium chloride, at 10 days before harvesting. Untreated trees served as control. Fruits were harvested at maturity stage, then packaged and stored at 0±1 °C and 85-90% of relative humidity. Fruit physical and chemical properties were evaluated at 7-day intervals. Results showed that pre-harvest application with 2% CaCl2+1% chitosan was most effective in minimizing weight loss (%) and decay (%), as well as in maintaining maximum firmness and lengthening shelf life. Fruit color was not affected by any of the treatments, while untreated fruits and calcium chloride treatment alone, at both applied concentrations, maintained higher total soluble solids (TSS, %), total phenolic content, and lower titratable acidity percentage.
RESUMO Estudos relacionados ao armazenamento de pêssego tem sido considerado de grande relevância no Egito. Neste estudo, o efeito da pulverização pré-colheita com cloereto de calico e quitosano, isoladamente ou em conjunto, na qualidade e na capacidade de armazenamento de frutos de pessegueiro armazenados a 0±1 °C foi avaliada. Frutos da variedade 'Early Swelling' foram tratados com 1,0 ou 2,0% de cloreto de cálcio. O primeiro tratamento foi aplicado num estado precoce de formação do fruto enquanto o segundo foi aplicado 10 dias antes da colheita. Quitosano foi aplicado nas concentrações de 0,5 ou 1,0%, isoladamente ou em combinação com 1,0% ou 2,0% de cloreto de cálcio também 10 dias antes da colheita. Árvores não tratadas serviram como controle. Os frutos foram colhidos quando maduros, empacotados e mantidos a 0±1 °C e sob condições de humidade relativa de 85-90%. Propriedades físicas e químicas dos frutos foram avaliadas em intervalos de 7 dias. Os resultados mostraram que a aplicação de 2% CaCl2 + 1% quitosano foi a mais eficaz em minimizar a perda de peso (%) e a senescência (%), bem como na manutenção da rigidez e aumento do período de vida em prateleira. A cor dos frutos não foi afectada por nenhum dos tratamentos enquanto frutos não tratados e cloreto de cálcio isoladamente, em ambas as concentrações, mantiveram um elevado teor de sólidos solúveis totais (TSS, %), elevado teor de fenóis e reduzida percentagem de acidez de titulação.
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Objective: To assess the sequelae of unilateral chewing on muscles of mastication via comparing the approximatemuscular volume (AMV) of the masseter (MM), medial pterygoid (MPM), temporalis (TM),superior and inferior lateral pterygoid muscles (SLPM/ILPM) bilaterally using MRI. Materials and methods:Twenty patients (16 females and 4 males) were selected from outpatient dental clinics of Kaser AlAini Hospitals, Cairo University, complaining from being unilaterally edentulous for one year or more. Alsosix fully dentate individuals (2 males and 4 females) were selected as control group. Magnetic ResonanceImaging (MRI) of the masticatory muscles was performed followed by measuring the approximate musclevolume (AMV) for each muscle bilaterally using the planimetry method. Results: Showed increase in theapproximate muscular volume (AMV) of the dentate side in both right side and left side edentulous patients.Conclusion: Our study shows the effect of long term unilateral chewing on decreasing the AMV in the nonfunctioningside, suggesting that measuring the approximate masticatory muscle volume using MRI couldbe helpful in detection of long-term functional disability of each muscle in comparison to adjacent muscles.
Objetivo: Avaliar as sequelas da mastigação unilateral sobre os músculos da mastigação por meio da comparaçãodo volume aproximado muscular (AMV) do músculo masseter (MM), pterigóideo medial (MPM), temporal(TM), músculos pterigóideos laterais superior e inferior (SLPM/ILPM) bilateralmente usando ressonânciamagnética. Materiais e métodos: Vinte pacientes (16 mulheres e 4 homens) foram selecionados a partir deambulatórios odontológicos do Hospital Kaser Al Aini, Universidade do Cairo; todos os participantes eram unilateralmentedesdentados há um ano ou mais. Também, seis indivíduos totalmente dentados (2 homens e 4mulheres) foram selecionados como grupo controle. Imagem por Ressonância Magnética (RM) dos músculosmastigatórios foi realizada seguido pela medição do volume muscular aproximada (AMV) para cada músculobilateral utilizando o método de planimetria. Resultados: Foi observado aumento no volume aproximadomuscular (AMV) do lado dentado em ambos os lados direito e esquerdo de desdentados laterais. Conclusão:Este estudo mostra o efeito em longo prazo da mastigação unilateral na diminuição da AMV no lado nãofuncional, o que sugere que a medição do volume muscular mastigatório aproximado usando ressonânciamagnética pode ser útil na detecção de deficiência funcional de cada músculo em comparação com músculosadjacentes em longo prazo.