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Arterial hypertension is a highly prevalent chronic disease worldwide, with several etiologies and treatments that may eventually have side effects or result in patients developing tolerance. There is growing interest in traditional medicine and functional foods to isolate biomolecules that could be useful as coadjuvants for treating several aliments. Pitaya, a desert fruit endemic in Mexico, is a rich source of bioactive molecules (betalains and phenolic compounds). In this work, the vasorelaxation properties of pitaya juice concentrate and fraction one were investigated using aortic and mesenteric rings from rats. The incubation of rings with pitaya juice concentrate or fraction one induced significant vasorelaxation, independent of the endothelium, and showed resistance to potassium channel blockers. This vasorelaxation was associated with the transmembrane influx of extracellular calcium through the vascular smooth muscle cells, with an inhibitory effect on the voltage-dependent calcium channel currents. Also, 400 mg/mL of pitaya juice concentrate in spontaneous hypertensive rats reduced their blood pressure for 48 h. Phytochemical analyses showed that the primary compounds in F1 were glycosidic in nature, and could be a complex mixture of disaccharides, dimeric disaccharides, or even tetrasaccharides. The glycosidic compounds found in F1 primarily contributed to vasodilatation, establishing a voltage-dependent calcium channel inhibition as a possible molecular target.
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Abstract Chronic kidney disease (CKD) has severe consequences on the quality and expectancy of life and is considered a major health problem worldwide. This is, especially relevant in pediatric patients, as they have unique characteristics and a mortality rate 30 times higher (in advanced stages) than healthy people. This review aims to define the minimum components for the diagnostic approach and monitoring of CKD in the pediatric population from primary health care to promote comprehensive care and adequate risk management. For this purpose, we performed a systematic review of the literature with a panel of experts. Based on the evidence, to optimize the definition, diagnosis, and timely treatment of CKD in the pediatric population, we formulated 21 recommendations. These were approved by the research team and peer-reviewed by clinical experts. They will facilitate the definition of the diagnostic approach for CKD in the pediatric population in primary health-care settings, allowing for timely treatment intervention, comprehensive care, and monitoring of this disease.
Resumen La enfermedad renal crónica (ERC) tiene graves consecuencias en la calidad y la esperanza de vida, y se considera un importante problema de salud a nivel mundial. Esto es especialmente relevante en pacientes pediátricos, ya que presenta características únicas y una tasa de mortalidad en etapas avanzadas que es 30 veces mayor que en personas sanas. El objetivo de esta revisión fue definir los componentes mínimos para el abordaje diagnóstico y para el seguimiento de la ERC en la población pediátrica desde la atención primaria en salud, con el fin de promover la atención integral y una adecuada gestión del riesgo. Para esto, se realizó una revisión sistemática de la literatura con panel de discusión de expertos. Basándonos en la evidencia, y con el objetivo de optimizar la definición, diagnóstico y tratamiento oportuno de la ERC en la población pediátrica, se formularon 21 recomendaciones. Estas fueron aprobadas por el equipo desarrollador y los pares expertos clínicos evaluadores, y permitirán definir de manera oportuna el abordaje diagnóstico de la ERC en la población pediátrica desde la atención primaria en salud, facilitando la intervención temprana, una atención integral y el seguimiento de esta patología.
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Chronic kidney disease (CKD) has severe consequences on the quality and expectancy of life and is considered a major health problem worldwide. This is, especially relevant in pediatric patients, as they have unique characteristics and a mortality rate 30 times higher (in advanced stages) than healthy people. This review aims to define the minimum components for the diagnostic approach and monitoring of CKD in the pediatric population from primary health care to promote comprehensive care and adequate risk management. For this purpose, we performed a systematic review of the literature with a panel of experts. Based on the evidence, to optimize the definition, diagnosis, and timely treatment of CKD in the pediatric population, we formulated 21 recommendations. These were approved by the research team and peer-reviewed by clinical experts. They will facilitate the definition of the diagnostic approach for CKD in the pediatric population in primary health-care settings, allowing for timely treatment intervention, comprehensive care, and monitoring of this disease.
La enfermedad renal crónica (ERC) tiene graves consecuencias en la calidad y la esperanza de vida, y se considera un importante problema de salud a nivel mundial. Esto es especialmente relevante en pacientes pediátricos, ya que presenta características únicas y una tasa de mortalidad en etapas avanzadas que es 30 veces mayor que en personas sanas. El objetivo de esta revisión fue definir los componentes mínimos para el abordaje diagnóstico y para el seguimiento de la ERC en la población pediátrica desde la atención primaria en salud, con el fin de promover la atención integral y una adecuada gestión del riesgo. Para esto, se realizó una revisión sistemática de la literatura con panel de discusión de expertos. Basándonos en la evidencia, y con el objetivo de optimizar la definición, diagnóstico y tratamiento oportuno de la ERC en la población pediátrica, se formularon 21 recomendaciones. Estas fueron aprobadas por el equipo desarrollador y los pares expertos clínicos evaluadores, y permitirán definir de manera oportuna el abordaje diagnóstico de la ERC en la población pediátrica desde la atención primaria en salud, facilitando la intervención temprana, una atención integral y el seguimiento de esta patología.
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Atención Primaria de Salud , Insuficiencia Renal Crónica , Humanos , Insuficiencia Renal Crónica/diagnóstico , Insuficiencia Renal Crónica/terapia , Niño , Atención Integral de Salud/organización & administraciónRESUMEN
Background. Neonatal high blood pressure has been diagnosed more frequently in recent years, and its impact extends to adulthood. However, the knowledge gaps on associated factors, diagnosis, and treatment are challenging for medical personnel. The incidence of this condition varies depending on neonatal conditions. Patients in the Newborn Unit are at increased risk of developing high blood pressure. The persistence of this condition beyond the neonatal stage increases the risk of cardiovascular disease and chronic kidney disease in childhood and adulthood. Methodology. A case-control study was carried out. It included hospitalized patients with neonatal hypertension as cases. Three controls were randomly selected for each case and matched by gestational age. The variables were analyzed based on their nature. Multivariate analysis was performed using a multivariate conditional regression model to identify variables associated with the outcome. Finally, the model was adjusted for possible confounders. Results. 37 cases were obtained and matched with 111 controls. In the univariate analysis, heart disease (OR 2.86; 95% CI 1.22-6.71), kidney disease (OR 7.24; 95% CI 1.92-28.28), bronchopulmonary dysplasia (OR 6.62; 95% CI 1.42-50.82) and major surgical procedures (OR 3.71; 95% CI 1.64-8.39) had an association with neonatal arterial hypertension. Only the latter maintained this finding in the multivariate analysis (adjusted OR 2.88; 95% CI 1.14-7.30). A significant association of two or more comorbidities with neonatal arterial hypertension was also found (OR 3.81; 95% CI 1.53-9.49). Conclusions. The study analyzed the factors related to high blood pressure in hospitalized neonates, finding relevant associations in the said population. The importance of meticulous neonatal care and monitoring of risk factors such as birth weight and major surgeries is highlighted.
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Hipertensión , Humanos , Estudios de Casos y Controles , Recién Nacido , Hipertensión/epidemiología , Hipertensión/complicaciones , Femenino , Masculino , Factores de Riesgo , Displasia Broncopulmonar/epidemiología , Displasia Broncopulmonar/complicaciones , Cardiopatías/epidemiología , Cardiopatías/complicaciones , Cardiopatías/etiologíaRESUMEN
Introducción: El cáncer de tiroides es una enfermedad frecuente en el mundo, con mayor prevalencia del tipo diferenciado. El diagnóstico temprano y manejo pertinente, individualizado y adaptable puede mejorar su pronóstico. Objetivo: Generar recomendaciones basadas en evidencia sobre el tratamiento y seguimiento de personas adultas con cáncer diferenciado de tiroides (CDT). Metodología: Guía de práctica clínica (GPC) a partir de revisión sistemática de literatura (RSL) y consenso de expertos clínicos. El grupo desarrollador definió el alcance y cuatro preguntas que se resolvieron a través de revisión de evidencia de GPC existentes, RSL, estudios primarios publicadas en español o inglés en diferentes fuentes de información desde 2013. Las preguntas de investigación fueron: 1. ¿Cuáles son las indicaciones de la vigilancia activa?, ¿cómo realizarla?, ¿cuándo y con que periodicidad realizarla? 2. ¿Cuál es el tratamiento y su indicación en pacientes con nódulos tiroideos sospechosos de cáncer? 3. ¿Cómo y cuándo realizar seguimiento de pacientes con CDT de acuerdo con el riesgo dinámico? 4. ¿Cuál es el manejo actual de los pacientes iodo refractarios? Se propusieron recomendaciones basadas en la evidencia, y analizadas y discutidas por el colectivo experto en sesiones asincrónicas. Se evalúo la calidad de la evidencia y las recomendaciones fueron gradadas en fuerte o condicional y a favor o en contra a partir del análisis de la calidad de la evidencia, contexto de implementación (disponibilidad e implementación) y la experticia clínica. En el presente documento se desarrollada la primera pregunta, referente a vigilancia activa. Resultados: 86 recomendaciones fueron propuestas y acordadas por el grupo desarrollador, categorizadas en tratamiento y seguimiento para resolver las preguntas planteadas. 10 de las recomendaciones corresponden a vigilancia activa y se incluyen en el presente documento. Recomendaciones claves incluyen, brindar información completa y oportuna a pacientes, conformación de equipos multidisciplinarios, análisis individualizado del paciente para la decisión de tratamiento, estadificación rutinaria de riesgo dinámico para evaluar la respuesta al tratamiento y ajustarlo, minimización de procedimientos fútiles o que aportan poco a la supervivencia y calidad de vida de los pacientes. Conclusión: Se presentan recomendaciones que esperan incidir en la estandarización de la práctica clínica cotidiana de pacientes con CDT y mejores resultados en salud.
Introduction: Thyroid cancer is a common disease in the world, with a higher prevalence of the differentiated type. Early diagnosis individualized and adaptive management can improve prognosis. Objective: Generate evidence-based recommendations on the treatment and follow-up of adults with differentiated thyroid carcinoma (DTC). Methodology: Clinical practice guideline (CPG) based on systematic literature review (RSL) and consensus of clinical experts. The development group defined the range and four questions that were resolved through a review of evidence from existing CPGs, RSLs, primary studies published in Spanish or English in various sources of information since 2013. The research questions were: 1. What are the indications for active surveillance? How to carry it out? When and how often to carry it out? 2. What is the treatment and its indication in patients with thyroid nodules suspicious for cancer? 3. How and when to follow up patients with CDT according to dynamic risk? 4. What is the current management of iodine refractory patients? Evidence-based recommendations analyzed and discussed by the expert group in asynchronous sessions were proposed. The quality of the evidence was evaluated, and the recommendations were graded as strong or conditional and in favor or against based on the analysis of the quality of the evidence, implementation context (availability and implementation) and clinical expertise. In this document, is developed the first question, referring to active surveillance. Results: 86 recommendations were proposed and agreed upon by the development group, categorized into treatment and follow-up to solve the questions raised. 10 of the recommendations correspond to active surveillance and are included in this document. Key recommendations include providing complete and timely information to patients, develop of multidisciplinary teams, individualized patient analysis for treatment decisions, routine dynamic risk staging to evaluate response to treatment and adjust it, minimization of futile procedures or that contribute little to the survival and quality of life of patients. Conclusion: Recommendations are presented that longs to influence the standardization of the daily clinical practice of patients with DTC and better health outcomes.
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Fundamento: Moodle rompe las limitaciones de espacio y tiempo en el proceso de enseñanza aprendizaje, fomenta el uso de recursos que posibilitan el desarrollo del proceso de evaluación y la independencia cognoscitiva de los estudiantes. Objetivo: diseñar una metodología para la preparación del docente sobre el uso de la plataforma Moodle en el proceso de evaluación de la disciplina Metodología de la Investigación en Salud. Métodos: se realizó una investigación de desarrollo en la Universidad de Ciencias Médicas de Holguín, curso 2022. Se emplearon métodos teóricos y empíricos. Se calcularon valores absolutos y porcentajes. El Alfa de Cronbach aplicado en el cuestionario a docentes resultó 0.73. Se seleccionaron cinco especialistas para la valoración de la metodología. Resultados: más de 50 % de los docentes expresaron que pocas veces o nunca emplean la plataforma Moodle para la evaluación frecuente y 86,7 % consideró regular el conocimiento que poseen; mientras el 84,4 % de los estudiantes la emplean para descargar materiales docentes. Se propone una metodología para la preparación del docente en la evaluación frecuente utilizando la plataforma, incluye instructivo y entrenamiento, fue estructurada en cinco etapas. Conclusiones: la metodología diseñada facilitó herramientas para la elaboración de la evaluación frecuente mediante la plataforma. Los especialistas la valoraron como aceptada para su aplicación.
Background: Moodle breaks the limitations of space and time in the teaching-learning process, encouraging the use of resources that enable the development of the evaluation process and the cognitive independence of students. Objective: design a methodology for teaching preparation on the use of the Moodle platform in the evaluation process of the Health Research Methodology discipline. Methods: a development investigation was carried out at Holguín University of Medical Sciences, academic year 2022. Theoretical and empirical methods were used. Absolute values and percentages were calculated. Cronbach's Alpha applied to the teacher's questionnaire was 0.73. Five specialists were selected to evaluate the methodology. Results: more than 50% of teachers expressed that they rarely or never use the Moodle platform for frequent evaluation and 86.7% considered they regulate the knowledge they possess; while 84.4% of students use it to download teaching materials. A methodology is proposed for teaching preparation in frequent evaluation using the platform, it includes instructions and training, it was structured in five stages. Conclusions: the designed methodology provided tools for the preparation of frequent evaluation through the platform. The specialists assessed it as accepted for application.
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resumen está disponible en el texto completo
ABSTRACT Background: Urinary tract infection (UTI) is a common disease in childhood and one of the most common causes of consultation in the pediatric emergency department. Its incidence ranges between 5% and 10% in children under 2 years old. Objective: To generate recommendations on the diagnosis, treatment, and follow-up of UTI in pediatric patients in Colombia. Methods: 15 questions of clinical interest in the diagnosis, treatment, and follow-up of UTI in pediatric patients were formulated. A systematic review of the literature was carried out to identify the clinical practice guidelines (CPG) available in UTI, in order to use this evidence to answer the proposed questions and articulate the recommendations. Local and international tools were used to select and evaluate the CPGs. Information was retrieved from the selected guidelines, preliminary recommendations were compiled, and final recommendations were approved by expert consensus. Finally, the strength and direction of each recommendation was assessed. Results: A total of 4 CPGs were selected: American Academy of Pediatrics, Spanish Ministry of Health, McTaggart, and National Institute for Health and Care Excellence. Final recommendations for the diagnosis, treatment, and follow-up of UTI are presented in this paper. Conclusions: These recommendations will guide the teams to make clinical decisions regarding health care of pediatric patients with UTI in Colombia. This will help to improve health care and to generate policies for timely diagnosis, treatment, and follow-up in these patients.
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Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a low-prevalence pathology mainly associated with pathogenic variants of the UMOD gene. It is characterized by the progressive deterioration of renal function, associated with hyperuricemia and accompanied by a family history of gout or hyperuricemia. Often, clinical variability and a lack of molecular testing results in diagnostic failure to determine the ADTKD-UMOD association. Case presentation: We describe the case of a 14-year-old male who presented to the nephrology service with hyperuricemia, renal ultrasonographic changes, and progression to chronic kidney disease in 4 years. He had a family history of hyperuricemia. A probable genetic disease with an autosomal dominant inheritance pattern was considered, confirmed by the presence of a probably pathogenic variant of the UMOD gene, not previously reported in the literature. Conclusion: The investigation of this case led to the identification of a new variant in the UMOD gene, broadening the spectrum of known variants for ADTKD-UMOD. In addition, in this case, a comprehensive anamnesis, that takes into account family history, was the key point to carry out genetic tests that confirmed the diagnosis suspicion. Directed Genetic tests are currently an essential diagnostic tool and should be performed as long as they are available and there is an indication to perform them.
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Gota , Hiperuricemia , Enfermedades Renales Poliquísticas , Masculino , Humanos , Adolescente , Uromodulina , Gota/genética , Pruebas Genéticas/métodos , Enfermedades Renales Poliquísticas/genética , MutaciónRESUMEN
Antecedentes: la enfermedad de Fabry (Ef) es una enfermedad rara ligada a X secundaria al depósito lisosomal de glicoesfingolípidos, debido a la deficiencia de la enzima alfa galactosidasa A (α-Gal A). A pesar de su baja frecuencia, es una condición que afecta la calidad de vida de los pacientes y disminuye su esperanza de vida. Objetivo: generar recomendaciones informadas para el diagnóstico y tratamiento de pacientes pediátricos (menores de 18 años) con Ef. Material y Métodos: revisión de literatura en bases de datos y literatura gris a partir de 2010, incluyendo guías de práctica clínica, revisiones sistemáticas y estudios primarios. La calidad de evidencia se evaluó de acuerdo con el tipo. Las recomendaciones se sometieron a consenso de expertos a través de metodología Delphi modificada. El acuerdo se definió a partir del 80 %. Resultados: A partir del análisis de la evidencia recolectada se formularon un total de 45 recomendaciones para tamización, diagnóstico y tratamiento de paciente pediátrico con Ef. El panel revisor estuvo conformado por once expertos en el tema. Las recomendaciones fueron aprobadas con puntuaciones entre 82.3 % y 100 %. Conclusiones: las recomendaciones resultantes del consenso de expertos permitirán la toma de decisiones clínicas y estandarización de la práctica en la atención de pacientes pediátricos con Ef en el país y la región. El diagnóstico temprano y oportuno garantiza una disminución del impacto en la calidad de vida de los pacientes y sus familiares
Background: Fabry disease (fD) is a rare X-linked disease characterized by the accumulation of glyco- sphingolipids in lysosomes due to the deficiency in the production of alpha-galactosidase A (α-Gal A) enzyme. Despite its low frequency, this disease has a serious impact on the life expectancy and quality. Objective: To make evidence-based recommendations for the diagnosis and treatment of fD in pediatric patients (<18 years of age). Materials and Methods: A study of databases and gray literature was conducted in 2010, including clinical practice guidelines, systematic reviews, and primary research. The type of evidence was used to determine the quality of evidence. The recommendations were submitted to an expert consensus using the modified Delphi process. The agreement was set at 80%. Conclusions: The recommendations emerging from this expert consensus will enable the standardization of care provision for pediatric patients with fD in Colombia and Latin America and clinical decision-making for disease management. Notably, making an early diagnosis ensures a reduction in the impact of this disease on the quality of life of patients and their families
Fundamento: a doença de Fabry (Df) é uma rara doença ligada ao cromossomo X secundária à deposi- ção lisossômica de glicoesfingolipídeos devido à deficiência da enzima alfa galactosidase A (α-Gal A). Apesar de sua baixa frequência, é uma condição que afeta a qualidade de vida dos pacientes e diminui sua expectativa de vida. Objetivo: gerar recomendações baseadas em evidências para o diagnóstico e tratamento de pacientes pediátricos (com menos de 8 anos de idade) com Df. Materais e Métodos: foi realizada uma revisão da literatura em bases de dados e literatura cinza a partir de 2010, incluindo diretrizes de prática clínica, revisões sistemáticas e estudos primários. A qualidade da evidência foi avaliada de acordo com o tipo de evidência. As recomendações foram submetidas ao consenso de especialistas usando a metodologia Delphi modificada. A concordância foi definida a partir de 80%. Resultados: com base na análise das evidências coletadas, foram formuladas um total de 45 recomendações para triagem, diagnóstico e tratamento de pacientes pediátricos com doença de Fabry. O painel de revisão foi composto por onze especialistas no assunto. As recomendações foram aprovadas com pontuações entre 82,3% e 100%. Conclusões: as recomendações resultantes do consenso de especialistas permitirão a tomada de decisão clínica e a padronização da prática no cuidado de pacientes pediátricos com Df em nível nacional e regional; o diagnóstico precoce e oportuno garante a redução do impacto na qualidade de vida dos pacientes e seus familiares.
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HumanosRESUMEN
RESUMEN Fundamento: la utilización de las tecnologías de la información y las comunicaciones en el primer año de la carrera de Medicina constituye una herramienta para desarrollar habilidades informáticas en cuanto a la búsqueda y recuperación de la información en salud. Objetivo: diseñar una estrategia de actualización en búsqueda y recuperación de información científica para desarrollar habilidades informáticas en el primer año de la carrera de Medicina. Métodos: se realizó un estudio de desarrollo en la Facultad de Ciencias Médicas de Holguín, se diseñó una estrategia con tres etapas: planificación, ejecución y evaluación. Para el estudio se seleccionó 220 estudiantes por muestreo aleatorio simple y de forma intencionada, a los profesores principales de las diferentes asignaturas que se imparten en el primer año de la carrera y los profesores de la disciplina Metodología de la Investigación en Salud. Resultados: se diseñó una estrategia de actualización en búsqueda y recuperación de información científica para desarrollar habilidades informáticas, en el primer año de la carrera de Medicina. La planificación para transmitir conocimientos básicos en la utilización del portal de Infomed y sus recursos. La ejecución se materializa con actividades teórico-prácticas referentes a la búsqueda y recuperación de información científica. En la tercera etapa se evalúo la actualización en búsqueda y recuperación de la información científica de forma integral. Conclusiones: con la estrategia se prepara a los estudiantes en la búsqueda y recuperación de la información científica, la cual desarrolla conocimientos y habilidades informáticas, según las exigencias del plan de estudio E en la carrera de Medicina.
ABSTRACT Background: the use of information and communication technologies in the first year of the Medicine career constitutes a tool to develop computer skills in search and retrieval of health information. Objective: to design an update strategy in search and retrieval of scientific information to develop computer skills in the first year of the Medicine degree. Methods: a development study was carried out at the Faculty of Medical Sciences of Holguín; a strategy was designed with three stages: planning, execution and evaluation. A sample of 220 students was selected by simple random sampling and intentionally, to the main teachers of the different subjects taught in the first year of the career and teachers of the discipline Health Research Methodology. Results: an update strategy was designed in search and retrieval of scientific information to develop computer skills in the first year of the Medicine degree. With three stages: Planning, execution and evaluation. Planning to transmit basic knowledge in the use of the Infomed portal and its resources. The execution is materialized with theoretical-practical activities related to the search and retrieval of scientific information. In the third stage, the updating in search and recovery of scientific information is evaluated in a comprehensive way. Conclusions: the strategy prepares students in the search and retrieval of scientific information, which develops computer knowledge and skills, according to the demands of study plan E in the Medicine degree.
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Abstract Introduction: The numbers of SARS-CoV-2 infection in the pediatric population are low so far. There is limited information about the behavior of SARS-CoV-2 in a pediatric patient with chronic kidney disease. Objective: To formulate informed recommendations to the prevention, diagnosis, and management of SARS-CoV-2 infection in pediatric patients with kidney disease or acute kidney injury associated with COVID-19 in Colombia. Methodology: A rapid systematic review was performed in Embase and Pubmed databases and scientific societies, to answer questions prioritized by clinical experts in pediatric nephrology. The quality of the evidence was evaluated with validated tools according to the type of study. The preliminary recommendations were consulted by an expert group. The agreement was defined when approval was obtained from at least 70% of the experts consulted. Results: A response was obtained from ' 9 experts in pediatric nephrology in Colombia, who declared the conflict of interest before the consultation. The range of agreement for the recommendations ranged from 78.9% to '00%. The recommendations did not require a second consultation. Conclusion: The evidence-based recommendations for the management of a patient with kidney disease and COVID-19 in the Colombian context are presented.
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Humanos , Masculino , Femenino , Preescolar , Niño , Adolescente , Pediatría , COVID-19 , Pacientes , Sociedades Científicas , Colombia , Insuficiencia Renal Crónica , Lesión Renal Aguda , NefrologíaRESUMEN
Cystinosis is a rare autosomal recessive lysosomal storage disorder, which leads to abnormal accumulation of cysteine in various organs, including progressive dysfunction of kidneys. The most severe and frequent form, affecting â¼95% of patients, is termed infantile nephropathic cystinosis (NC) (OMIM 219800). We have reported oral findings in two patients with NC and described esthetic and functional rehabilitation in one of them. The first case describes a 16-year-old male patient, who was diagnosed with NC when he was 1-year-old. The patient exhibited generalized enamel hypoplasia, grade 1 drug-induced gingival overgrowth, caries lesion in molar tooth and supernumerary tooth (ie, distomolar). The second case describes a 14-year-old male patient diagnosed with NC at 3 years old. Clinical examination revealed generalized enamel hypoplasia and grade 1 drug-induced gingival overgrowth. Radiographic examination showed supernumerary tooth (mesiodens). The treatment included gingivoplasty and restoration with direct composite resin. The severity of hypoplasia highlights the importance of a dental rehabilitation treatment, as proposed here. Direct restoration with composite resin allowed harmony, function, and esthetics to be restored, in addition to being a rapid and low-cost technique.
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Cistinosis , Caries Dental , Adolescente , Preescolar , Humanos , Lactante , MasculinoRESUMEN
RESUMEN Fundamento: las estrategias curriculares se aplican para alcanzar objetivos relacionados con conocimientos y habilidades en la formación del egresado. Objetivo: valorar la aplicación de la metodología para implementar la estrategia curricular de investigación e informática en tercer año de Medicina. Método: se realizó una investigación de evaluación en la Facultad de Ciencias Médicas de la Universidad de Ciencias Médicas de Holguín, entre marzo-julio de 2017; se aplicaron métodos teóricos: análisis-síntesis, inducción-deducción e histórico-lógico; empíricos: la revisión documental, la observación a clases y la encuesta en forma de cuestionario a estudiantes y profesores; y procedimientos estadísticos: el cálculo de los índices relativo y de posición, la correlación elemento escala y el Alfa de Cronbach. Resultados: se determinaron tres variables para cumplir el objetivo de la investigación: conocimiento de la metodología para implementar la estrategia curricular de investigación e informática en su dimensión teórica y práctica, la cual fue valorada como parcialmente cumplida; preparación de los profesores, donde se comprobó que están orientados en cómo aplicar sus acciones; y preparación de los estudiantes, cumplida parcialmente pues fueron asignados valores bajos en algunos de sus ítems, y luego de triangulada esta información con los resultados de la observación a clases, se determinaron algunas insuficiencias en su aplicación. Conclusiones: el estudio realizado de los datos obtenidos con la aplicación de los métodos y procedimientos estadísticos permitió valorar que la aplicación de la metodología se cumplió de forma parcial durante el período analizado.
ABSTRACT Background: curricular strategies are applied to achieve objectives related to knowledge and skills in graduate education. Objective: to assess the application of the methodology to implement the curricular strategy of researching and computing sciences in the third year of Medicine. Methods: an assessment research was carried out at the Faculty of Medical Sciences of Holguín University of Medical Sciences, from March to July 2017; Theoretical methods were applied: analysis-synthesis, induction-deduction and historical-logical; empirical methods: the documentary review, the observation to classes and the questionnaire survey to students and professors; and statistical procedures: the calculation of the relative and position indices, the scale element correlation and the Cronbach's Alpha. Results: three variables were determined to meet the researching objective: knowledge of the methodology to implement the curricular strategy of researching and computing in its theoretical and practical dimension, which was assessed as partially fulfilled; teacher preparation, where it was proven that they are oriented on how to apply their actions; and preparation of the students, partially fulfilled because they were assigned low values in some of its items, and after triangulating this information with the results of the observation to classes, some insufficiencies in its application were determined. Conclusions: the study of the data obtained with the application of the statistical methods and procedures made it possible to assess that the application of the methodology was partially met during the period analyzed.
Asunto(s)
Investigación , Proyectos de Investigación , Estrategias de Salud , Educación MédicaRESUMEN
Introducción: La evidencia empírica dispar relacionada con el efecto del gasto público en materia sanitaria puede deberse a las importantes variaciones metodológicas de los estudios y a las diferencias significativas en la forma en que el gasto público influye dependiendo del nivel de desarrollo de los países. Objetivo: Determinar la relación entre el gasto público total del Gobierno general y la mortalidad infantil y la esperanza de vida. Métodos: Investigación realizada en una muestra de 78 países segmentada por niveles de renta, desde 1990 hasta 2012. Se constituyeron cinco submuestras de países divididos por su nivel de renta mediante un procedimiento de agrupación no jerárquico de k-medias. Se verificó la procedencia de la segmentación mediante el test de Chow. Para cada una de las submuestras construidas, se estimó el modelo correspondiente por mínimos cuadrados generales lineales y un test de cointegración. Resultados: En las submuestras superiores en nivel de renta, la salud se relacionó significativa y consistentemente con el gasto público. Sin embargo, en los países de renta inferior-baja, el coeficiente del gasto presentó un signo contrario al esperado. Conclusiones: Se demuestra un impacto positivo y de largo plazo entre el gasto público y la situación sanitaria. Sin embargo, para los países de menor renta, este parece haber superado su punto óptimo, lo que indicaría su ineficiencia en términos sanitarios. Se conjetura que lo anterior se debe a la baja capacidad institucional de estos países, lo que impide que un mayor gasto obtenga mejores resultados sanitarios(AU)
Introduction: The disparate empirical evidence related with the effect of public expenditure on health may be due to the significant methodological variations of the studies, as well as the significant differences in the way in which public expenditure influences depending on the level of development of the countries. Objective: To determine the relation among the total public expenditure of the General Government, and infant mortality and life expectancy. Methods: Research project carried out with a sample of 78 countries segmented by income levels from 1990 to 2012. By means of a non - hierarchical grouping of k - media, five sub-samples of countries were formed and divided by their income level. The origin of the segmentation was verified by means of the Chow test. Linear GLS and a cointegration test were applied on each subsample. Results: In the upper subsamples at the income level, health was significantly and consistently related to public expenditure. However, in the lower-low income countries, the expenditure coefficient showed a sign opposite to that expected. Conclusions: There is evidence of a positive and long-term impact among public expenditure and the health situation. However, for lower income countries, this seems to have surpassed its optimum point, which would indicate its inefficiency in sanitary terms. It is conjectured that this is due to the low institutional capacity of these countries, which hampers that greater expenditure obtains better sanitary results(AU)
Asunto(s)
Humanos , Financiación Gubernamental/economía , Salud Global/tendencias , Gastos en Salud/estadística & datos numéricos , Renta per Cápita/estadística & datos numéricosRESUMEN
Introducción: La evidencia empírica dispar relacionada con el efecto del gasto público en materia sanitaria puede deberse a las importantes variaciones metodológicas de los estudios y a las diferencias significativas en la forma en que el gasto público influye dependiendo del nivel de desarrollo de los países. Objetivo: Determinar la relación entre el gasto público total del Gobierno general y la mortalidad infantil y la esperanza de vida. Métodos: Investigación realizada en una muestra de 78 países segmentada por niveles de renta, desde 1990 hasta 2012. Se constituyeron cinco submuestras de países divididos por su nivel de renta mediante un procedimiento de agrupación no jerárquico de k-medias. Se verificó la procedencia de la segmentación mediante el test de Chow. Para cada una de las submuestras construidas, se estimó el modelo correspondiente por mínimos cuadrados generales lineales y un test de cointegración. Resultados: En las submuestras superiores en nivel de renta, la salud se relacionó significativa y consistentemente con el gasto público. Sin embargo, en los países de renta inferior-baja, el coeficiente del gasto presentó un signo contrario al esperado. Conclusiones: Se demuestra un impacto positivo y de largo plazo entre el gasto público y la situación sanitaria. Sin embargo, para los países de menor renta, este parece haber superado su punto óptimo, lo que indicaría su ineficiencia en términos sanitarios. Se conjetura que lo anterior se debe a la baja capacidad institucional de estos países, lo que impide que un mayor gasto obtenga mejores resultados sanitarios(AU)
Introduction: The disparate empirical evidence related with the effect of public expenditure on health may be due to the significant methodological variations of the studies, as well as the significant differences in the way in which public expenditure influences depending on the level of development of the countries. Objective: To determine the relation among the total public expenditure of the General Government, and infant mortality and life expectancy. Methods: Research project carried out with a sample of 78 countries segmented by income levels from 1990 to 2012. By means of a non - hierarchical grouping of k - media, five sub-samples of countries were formed and divided by their income level. The origin of the segmentation was verified by means of the Chow test. Linear GLS and a cointegration test were applied on each subsample. Results: In the upper subsamples at the income level, health was significantly and consistently related to public expenditure. However, in the lower-low income countries, the expenditure coefficient showed a sign opposite to that expected. Conclusions: There is evidence of a positive and long-term impact among public expenditure and the health situation. However, for lower income countries, this seems to have surpassed its optimum point, which would indicate its inefficiency in sanitary terms. It is conjectured that this is due to the low institutional capacity of these countries, which hampers that greater expenditure obtains better sanitary results(AU)
Asunto(s)
Humanos , Renta per Cápita/estadística & datos numéricos , Salud Global/tendencias , Gastos en Salud/estadística & datos numéricos , Financiación Gubernamental/economíaRESUMEN
Often, young patients (≤30 years old) present with carious lesions that progress acutely, compromising a large amount of tooth structure. In these cases, a treatment to prevent the occurrence of pulp exposure and promote remineralization of caries-affected dentin is necessary to maintain healthy dental structure and allow more conservative interventions. The approach will be different when pulp exposure occurs: The therapeutic treatments will be focused on reparative dentin formation and prevention of microorganisms penetrating the pulp organ. Due to the different possible treatments that can be performed to avoid pulp necrosis and the various materials that can be used for this purpose, professionals may have some difficulties understanding all the indications for conservative pulp treatments. The objective of this article is to describe and discuss a successful pulp capping and stepwise excavation associated with restorative treatment for deep caries lesions of anterior upper teeth.
Asunto(s)
Caries Dental/terapia , Recubrimiento de la Pulpa Dental , Necrosis de la Pulpa Dental/prevención & control , Restauración Dental Permanente/métodos , Niño , Preparación de la Cavidad Dental , Humanos , Masculino , Remineralización DentalRESUMEN
Introducción: ante el auge del empleo de las tecnologías de informática y comunicaciones en las universidades, se confeccionó un software educativo para favorecer el proceso de enseñanza aprendizaje de la asignatura de Metodología de la Investigación y Estadística. Objetivos: mostrar la validación del software educativo de Metodología de la Investigación y Estadística para su generalización en segundo año de la carrera de medicina en la provincia Holguín. Método: se realizó una investigación de evaluación en educación médica en el campo de recursos de aprendizaje en la Facultad de Ciencias Médicas Mariana Grajales Coello de Holguín desde septiembre de 2013 a febrero de 2014. Se emplearon métodos teóricos como el análisis-síntesis, análisis documentales; empíricos como encuesta y observación; y métodos estadísticos así como procedimientos matemáticos. Para determinar si el software es generalizable se evaluó según la metodología propuesta por Madariaga. Resultados: se constató que el software educativo puede ser empleado en todas las formas de organización de la enseñanza. La evaluación interna del software obtuvo el 98% del valor final de todos los criterios analizados y la evaluación externa se consideró el empleo del software educativo con la muestra estudiantil y los profesores que lo utilizaron; se obtuvo 91% de la puntuación total. Conclusiones: el software educativo para la enseñanza de la asignatura Metodología de la Investigación y Estadística es generalizable para su uso en los distintos escenarios de la provincia Holguín.
Introduction: with the growth of the use of information and communications technologies in the universities, educational software was compiled to help the process of learning of the subject Research Methodology and Statistics. Objectives: to validate the educational software Research Methodology and Statistics for generalization second year medical career in Holguin province. Method: an evaluation research was conducted in medical education in the field of learning resources at the Faculty of Medical Sciences Holguin September 2013 to February 2014. Theoretical methods such as analysis-synthesis, documentary analysis were used; as well as empirical and Survey and observation; and statistical methods and mathematical procedures. To determine whether the software is generalizable was evaluated according to the methodology proposed by Madariaga. Results: the results showed that educational software can be used in all forms of organization of teaching. As part of the internal evaluation software it won 98% of the final value of all the criteria analyzed. As part of the external evaluation, the use of SE was considered in the students and teachers samples, and 91% of the total score was obtained. Conclusions: educational software for teaching Research Methodology and Statistics course is generalizable for use in the various stages of Holguin province.
RESUMEN
Introducción: ante el auge del empleo de las tecnologías de informática y comunicaciones en las universidades, se confeccionó un software educativo para favorecer el proceso de enseñanza aprendizaje de la asignatura de Metodología de la Investigación y Estadística.Objetivos: mostrar la validación del software educativo de Metodología de la Investigación y Estadística para su generalización en segundo año de la carrera de medicina en la provincia Holguín.Método: se realizó una investigación de evaluación en educación médica en el campo de recursos de aprendizaje en la Facultad de Ciencias Médicas Mariana Grajales Coello de Holguín desde septiembre de 2013 a febrero de 2014. Se emplearon métodos teóricos como el análisissíntesis, análisis documentales; empíricos como encuesta y observación; y métodos estadísticos así como procedimientos matemáticos. Para determinar si el software es generalizable se evaluó según la metodología propuesta por Madariaga.Resultados: se constató que el software educativo puede ser empleado en todas las formas de organización de la enseñanza. La evaluación interna del software obtuvo el 98 por ciento del valor final de todos los criterios analizados y la evaluación externa se consideró el empleo del software educativo con la muestra estudiantil y los profesores que lo utilizaron; se obtuvo 91por ciento de la puntuación total.Conclusiones: el software educativo para la enseñanza de la asignatura Metodología de la Investigación y Estadística es generalizable para su uso en los distintos escenarios de la provincia Holguín(AU)
Introduction: with the growth of the use of information and communications technologies in the universities, educational software was compiled to help the process of learning of the subject Research Methodology and Statistics.Objectives: to validate the educational software Research Methodology and Statistics for generalization second year medical career in Holguin province.Method: an evaluation research was conducted in medical education in the field of learning resources at the Faculty of Medical Sciences Holguin September 2013 to February 2014. Theoretical methods such as analysis-synthesis, documentary analysis were used; as well as empirical and Survey and observation; and statistical methods and mathematical procedures. To determine whether the software is generalizable was evaluated according to the methodology proposed by Madariaga.Results: the results showed that educational software can be used in all forms of organization of teaching. As part of the internal evaluation software it won 98 percent of the final value of all the criteria analyzed. As part of the external evaluation, the use of SE was considered in the students and teachers samples, and 91 percent of the total score was obtained.Conclusions: educational software for teaching Research Methodology and Statistics course is generalizable for use in the various stages of Holguin province(AU)
Asunto(s)
Humanos , Educación Médica , Evaluación Educacional , Programas InformáticosRESUMEN
Introducción: La fibrilación auricular (FA), con una incidencia aproximada del 30%, es la arritmia más frecuente tras cirugía cardiaca. Se han asociado a la FA factores como la inflamación, la presencia de fibrosis cardiaca, el estrés y la apoptosis de cardiomiocitos. Objetivos: Consideramos que el remodelado auricular es un proceso preexistente en los pacientes con FA posquirúrgica. Analizamos los factores relacionados con la incidencia de FA en el postoperatorio de cirugía cardiaca. Métodos: Incluimos a pacientes consecutivos, estables hemodinámicamente y en ritmo sinusal, sometidos a cirugía cardiaca programada con circulación extracorpórea. Se valora la caída en FA posquirúrgica. Resultados: Se incluyeron un total de 100 pacientes sometidos a cirugía de revascularización coronaria (59) o sustitución valvular aórtica (41) por estenosis aórtica grave. La FA postoperatoria se produjo en 29 pacientes con predominio de la cirugía valvular respecto a la cirugía coronaria. Los factores predictivos de la aparición de FA postoperatoria en el análisis multivariable fueron el sexo masculino, la ausencia de terapia crónica con betabloqueadores, la perfusión de fibrinógeno intraoperatorio, valores bajos de colesterol HDL y valores elevados de troponina T ultrasensible en el preoperatorio. Conclusiones: El colesterol HDL y la troponina T ultrasensible pueden ser biomarcadores útiles para predecir la aparición de FA postoperatoria. La identificación precoz de estos pacientes nos permite adoptar medidas preventivas para minimizar sus efectos negativos.
Introduction: Atrial fibrillation (AF) has an incidence rate of approximately 30% and is the most frequent arrhythmia following heart surgery. Factors such as inflammation, the presence of heart fibrosis, stress and cardiomyocyte apoptosis, have all been associated with AF. Objectives: We believe that atrial remodelling is a pre-existent process in patients with post-surgical AF. We have analyzed the factors related to the incidence of atrial fibrillation in the period after heart surgery. Methods: We included consecutive, hemodynamically stable patients with a sinusal rhythm who were subjected to programmed heart surgery with extracorporeal circulation. An assessment was made of the fall in atrial fibrillation after surgery using prolonged electrocardiographic monitoring. Results: A total of 100 patients were included in the study and were subjected to either coronary revascularisation surgery (59) or aortic valve substitution due to severe aortic stenosis (41). Postoperative AF occurred in 29 patients who received predominantly more valve surgery than coronary surgery. The following factors were predictive of postoperative AF in the multivariate analysis: Male sex; beta-blocker therapy for chronic disease; the use of intraoperative; fibrinogen perfusion; low HDL cholesterol values; and high sensitive troponin T values, in the preoperative period. Conclusions: HDL cholesterol and high sensitive troponin T can be useful biomarkers to predict the occurrence of AF after surgery. The early identification of these patients who develop of FA allows us to take preventive measures to minimize the negative effects.
Asunto(s)
Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fibrilación Atrial/sangre , HDL-Colesterol/sangre , Complicaciones Posoperatorias/sangre , Troponina T/sangre , Biomarcadores/sangre , Procedimientos Quirúrgicos Cardíacos , Valor Predictivo de las PruebasRESUMEN
INTRODUCTION: Atrial fibrillation (AF) has an incidence rate of approximately 30% and is the most frequent arrhythmia following heart surgery. Factors such as inflammation, the presence of heart fibrosis, stress and cardiomyocyte apoptosis, have all been associated with AF. OBJECTIVES: We believe that atrial remodelling is a pre-existent process in patients with post-surgical AF. We have analyzed the factors related to the incidence of atrial fibrillation in the period after heart surgery. METHODS: We included consecutive, hemodynamically stable patients with a sinusal rhythm who were subjected to programmed heart surgery with extracorporeal circulation. An assessment was made of the fall in atrial fibrillation after surgery using prolonged electrocardiographic monitoring. RESULTS: A total of 100 patients were included in the study and were subjected to either coronary revascularisation surgery (59) or aortic valve substitution due to severe aortic stenosis (41). Postoperative AF occurred in 29 patients who received predominantly more valve surgery than coronary surgery. The following factors were predictive of postoperative AF in the multivariate analysis: Male sex; beta-blocker therapy for chronic disease; the use of intraoperative; fibrinogen perfusion; low HDL cholesterol values; and high sensitive troponin T values, in the preoperative period. CONCLUSIONS: HDL cholesterol and high sensitive troponin T can be useful biomarkers to predict the occurrence of AF after surgery. The early identification of these patients who develop of FA allows us to take preventive measures to minimize the negative effects.