RESUMEN

Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs), being α-amino acids and their derivatives widely applied as building blocks. In this work we developed two different strategies for the synthesis of intermediates used on the synthesis of levetiracetam/brivaracetam and ethambutol. The results obtained show that methionine methyl ester can be continuously converted to the desired ethambutol intermediate by RANEY® Nickel dessulfurization/reduction strategy whereas levetiracetam/brivaracetam intermediates could be synthesized by both RANEY® Nickel (without H2) and Pd/C-H2 approach or by photochemical desulfurization.

Asunto(s)

Anticonvulsivantes/síntesis química , Anticonvulsivantes/farmacología , Antituberculosos/síntesis química , Antituberculosos/farmacología , Anticonvulsivantes/química , Antituberculosos/química , Técnicas de Química Sintética , Etambutol/síntesis química , Etambutol/química , Etambutol/farmacología , Levetiracetam/síntesis química , Levetiracetam/química , Levetiracetam/farmacología , Pirrolidinonas/síntesis química , Pirrolidinonas/química , Pirrolidinonas/farmacología , Estereoisomerismo , Azufre/química