RESUMEN
Chronic venous ulcers (CVU) of the lower limbs (LL) are common and cause psychological changes and significant social impact, as they make the patient susceptible to pain, absence from work and social bonds. Some materials are suggested as dressings for the treatment of CVU, but they are expensive and are generally not available for use in public health services. To evaluate the efficacy of the treatment for lower limbs (LL) chronic venous ulcer (CVU) using bacterial cellulose (BC), gel and multi-perforated film associated. A randomized controlled clinical-intervention study was performed among participants with LL CVU, divided into two groups: experimental (EG), treated with BC wound dressing and control (CG), treated with a cellulose acetate mesh impregnated with essential fatty acids (Rayon®). The participants were followed for 180 days, evaluated according to the MEASURE methodology. Thirty-nine patients were treated, 20 from the EG and 19 from the CG. In both groups, the wound area decreased significantly (p < 0.001), the healing rate was similar to the CG. The mean number of dressing changes in the SG was 18.33 ± 11.78, while in the CG it was 55.24 ± 25.81, p < 0.001. The healing dressing of bacterial cellulose, gel and associated film, when stimulating the epithelization of the lesions, showed a significant reduction in the initial area, with a percentage of cure similar to the Rayon® coverage. In addition to requiring less direct manipulation of ulcers.
Asunto(s)
Bacterias/metabolismo , Vendas Hidrocoloidales , Celulosa/química , Úlcera Varicosa/tratamiento farmacológico , Adhesividad , Adulto , Anciano , Anciano de 80 o más Años , Ácidos Grasos/química , Ácidos Grasos Esenciales/química , Femenino , Geles , Humanos , Extremidad Inferior , Masculino , Ensayo de Materiales , Persona de Mediana Edad , Riesgo , Cicatrización de HeridasRESUMEN
Purpose: To analyze the interaction between the cellulose exopolysaccharide (CEC) and urethral tissue when used as a pubovaginal sling. Materials and Methods: Forty Wistar rats were divided into four groups. In groups A and B the cellulose exopolysaccharide (CEC) was implanted around the urethral tissue (bladder neck below the upper margin) and the rats were sacrificed at 30 and 90 days. Similar procedure was used in groups C and D using a polypropylene mesh. After sacrifice bladder and urethra were sent for histological analysis. The histological parameters (inflammatory reaction) by evaluated by quantitative analysis. For collagen deposition analysis it was used stereological method. Results: The cellulose exopolysaccharide (CEC) was inert and well preserved at the implanted region at the time of examination. Morphologic alterations were not found at the CEC implant but some reactions of foreign body type were observed at the adjacent structures. In some areas a process of neovascular formation was observed. Stereological analysis at the suburethral area showed a significant difference in collagen presence in favor of CEC. Conclusions: The CEC implant showed adequate results when used as a suburethral sling with good integration to the host tissue, preserving its architecture.
Asunto(s)
Animales , Femenino , Biopolímeros/uso terapéutico , Celulosa/uso terapéutico , Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo/cirugía , Materiales Biocompatibles/uso terapéutico , Colágeno/análisis , Reacción a Cuerpo Extraño , Implantación de Prótesis , Polipropilenos/uso terapéutico , Ratas Wistar , Reproducibilidad de los Resultados , Mallas Quirúrgicas , Factores de Tiempo , Resultado del Tratamiento , Incontinencia Urinaria de Esfuerzo/patologíaRESUMEN
PURPOSE: To analyze the interaction between the cellulose exopolysaccharide (CEC) and urethral tissue when used as a pubovaginal sling. MATERIALS AND METHODS: Forty Wistar rats were divided into four groups. In groups A and B the cellulose exopolysaccharide (CEC) was implanted around the urethral tissue (bladder neck below the upper margin) and the rats were sacrificed at 30 and 90 days. Similar procedure was used in groups C and D using a polypropylene mesh. After sacrifice bladder and urethra were sent for histological analysis. The histological parameters (inflammatory reaction) by evaluated by quantitative analysis. For collagen deposition analysis it was used stereological method. RESULTS: The cellulose exopolysaccharide (CEC) was inert and well preserved at the implanted region at the time of examination. Morphologic alterations were not found at the CEC implant but some reactions of foreign body type were observed at the adjacent structures. In some areas a process of neovascular formation was observed. Stereological analysis at the suburethral area showed a significant difference in collagen presence in favor of CEC. CONCLUSIONS: The CEC implant showed adequate results when used as a suburethral sling with good integration to the host tissue, preserving its architecture.
Asunto(s)
Biopolímeros/uso terapéutico , Celulosa/uso terapéutico , Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo/cirugía , Animales , Materiales Biocompatibles/uso terapéutico , Colágeno/análisis , Femenino , Reacción a Cuerpo Extraño , Polipropilenos/uso terapéutico , Implantación de Prótesis , Ratas Wistar , Reproducibilidad de los Resultados , Mallas Quirúrgicas , Factores de Tiempo , Resultado del Tratamiento , Incontinencia Urinaria de Esfuerzo/patologíaRESUMEN
A statistical study on the behavior of ground-level O3 concentration in different regions of a large urban area was carried out, with emphasis on pollutant gas concentrations and meteorological variables. The study was based on data generated by a network of measuring stations distributed throughout the São Paulo Metropolitan Area, in regions with different characteristics of traffic and economic activities. The combined application of principal component analysis and clustering techniques to data collected from 1997 until 2000 has led to the identification of implicit relationships between variables that have been associated with dominant processes related to O3 formation in different locations. Similarities between different regions of the city have also been detected and associated with local characteristics. The results indicate that the application of such statistical techniques to data collected in large urban areas enables the grouping of different regions according to their behavior in terms of O3 levels, as well as the identification of dominant processes in each group. These techniques are thus important in the planning of air pollution policies, especially in the case of O3, a pollutant that is not directly related to pollution levels alone.