RESUMEN
Microbes are unique creatures that adapt to varying lifestyles and environment resistance in extreme or adverse conditions. The genetic architecture of microbe may bear a significant signature not only in the sequences position, but also in the lifestyle to which it is adapted. It becomes a challenge for the society to find new chemical entities which can treat microbial infections. The present review aims to focus on account of important chemical moiety, that is, pyrimidine and its various derivatives as antimicrobial agents. In the current studies we represent more than 200 pyrimidines as antimicrobial agents with different mono-, di-, tri-, and tetrasubstituted classes along with in vitro antimicrobial activities of pyrimidines derivatives which can facilitate the development of more potent and effective antimicrobial agents.
RESUMEN
BACKGROUND: There is a lack of knowledge about epilepsy among the students and the population in general, with consequent prejudice and discrimination toward epileptic patients. OBJECTIVES: Knowledge, behavior, attitude and myth toward epilepsy among urban school children in Bareilly district was studied. MATERIALS AND METHODS: A cross-sectional survey was conducted among students of 10 randomly selected secondary schools of the urban areas in Bareilly district. A structured, pretested questionnaire was used to collect data regarding sociodemographic characteristics and assess the subject's knowledge, behavior, attitude and myth toward epilepsy. RESULTS: Of the 798 students (533 boys and 265 girls) studied, around 98.6% had heard of epilepsy. About 63.7% correctly thought that epilepsy is a brain disorder while 81.8% believed it to be a psychiatric disorder. Other prevalent misconceptions were that epilepsy is an inherited disorder (71.55%) and that the disease is transmitted by eating a nonvegetarian diet (49%). Most of them thought that epilepsy can be cured (69.3) and that an epileptic patient needs lifelong treatment (77.2). On witnessing a seizure, about 51.5% of the students would take the person to the hospital. Majority (72.31%) of the students thought that children with epilepsy should study in a special school. CONCLUSIONS: Although majority of the students had reasonable knowledge of epilepsy, myths and superstitions about the condition still prevail in a significant proportion of the urban school children. It may be worthwhile including awareness programs about epilepsy in school education to dispel misconceptions about epilepsy.