RESUMEN
To determine the relative frequencies of gastrointestinal diseases (GI) in patients admitted to Samtah General Hospital, Gizan, the records of 2,442 adults admitted to the medical and surgical services for gastrointestinal diseases during the period 1413 to 1416 were analyzed retrospectively. 1,028 patients had acute appendicitis. The remaining 1,414 patients were admitted for various other GI diseases. In these 1,414 patients the commonest diseases were gastrointestinal infections (36.4%), peptic ulcer disease (19%), gall bladder disease (18.5%), viral hepatitis and its sequelae (20.7%). Despite the high prevalence of cholelithiasis, acute pancreatitis was uncommon (0.1 %). Inflammatory bowel disease was rare. There was no gender - related difference in the prevalence of gastrointestinal infections, peptic ulcer disease and carcinoma of the stomach. Males were significantly more afflicted than females with viral hepatitis (p< 0.0001), cirrhosis of the liver (p< 0.0001), hepatocellular carcinoma (p< 0.0005), variceal bleeding (p< 0.0005), and peptic ulcer bleeding (p< 0.005). As a large proportion of our patients had preventable diseases, it is expected that immunization and other public health measures will reduce the frequency of these diseases in the future.
RESUMEN
3 cases of aplastic anaemia occurring in association with anti-tuberculosis chemotherapy are reported. The patients had been on anti-tuberculosis chemotherapy for 13, 11 and 14 months, respectively, prior to the diagnosis of aplastic anaemia. Agents used included streptomycin, thiacetazone, isoniazid, p-aminosalicylic acid and dimethylcarbazine. Recovery from aplasia did not occur 6. 1.5 and 0.8 months, respectively, after the discontinuation of the suspect myelotoxic agents and despite the use of myelostimulatory agents. All 3 patients died of haemorrhage secondary to thrombocytopenia. The observations are consistent with a protracted and probably irreversible damage of the bone marrow by anti-tuberculosis agent(s) in susceptible individuals.
Asunto(s)
Anemia Aplásica/inducido químicamente , Antituberculosos/efectos adversos , Tuberculosis Laríngea/tratamiento farmacológico , Tuberculosis Pulmonar/tratamiento farmacológico , Acridinas/efectos adversos , Adulto , Ácido Aminosalicílico/efectos adversos , Quimioterapia Combinada , Femenino , Humanos , Isoniazida/efectos adversos , Masculino , Persona de Mediana Edad , Nigeria , Piridoxina/efectos adversos , Estreptomicina/efectos adversos , Tioacetazona/efectos adversosAsunto(s)
Endoscopía , Enfermedades Gastrointestinales/diagnóstico , Adolescente , Adulto , Anciano , Niño , Esofagoscopía , Femenino , Gastroscopía , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The aetiological factors at work in Nigerians with duodenal ulcer were examined. Stress and dietary factors were found to be major agents in the precipitation of exacerbations and recurrences of symptoms. Of the dietary agents, chillies and cassava preparations in the form of 'eba' and 'gari' are potent ulcerogenic food substances. Aspirin, alcohol and smoking also contribute to the worsening of the conditions but are not major factors.