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The distribution of skeletal metastases in prostatic and lung cancer was examined to test the hypothesis that prostatic carcinoma spreads by a unique hematogenous route. Abnormal technetium-99m methylene diphosphonate bone scans were retrospectively reviewed in 71 patients with prostatic carcinoma and 41 patients with lung cancer comparing patterns of osseous involvement. Differences in the distribution of lesions were not significant. It is concluded that prostatic carcinoma does not metastasize to specific skeletal sites by a singular hematogenous pathway.

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Roux-en-Y patients have symptoms that vary from almost none to inability to tolerate oral feedings. This study was designed to determine whether there is a relationship between a patient's symptoms and the function of the gastric remnant or the Roux-limb. Gastric remnant and Roux-limb emptying were studied in eight patients with technetium-99m-labeled oatmeal and Roux-limb motor activity was measured with a water-perfused manometry system. We found that gastric emptying was rarely significantly slowed, but emptying of the Roux-limb was delayed in several patients. We also found that there was a rough correlation between the patient's symptoms and the degree of abnormal motility found in the Roux-limb. There is no known reason for these abnormalities in Roux-limb function in some patients after a Roux-en-Y, but our finding of worse abnormalities in those who had multiple previous gastric surgeries suggests that the symptoms and dysfunction may be related to the number of surgeries, as well as to the type of surgery.

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Intrathoracic lipomas are often asymptomatic and incidentally discovered on routine chest radiographs. An infarcted, pedunculated thoracic lipoma causing chest pain is described. The possibility of liposarcoma was suggested by an inhomogeneous computed tomography appearance and an attenuation value that was greater than that of normal subcutaneous fat.

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Technetium-99m albumin-sucralfate ([99mTc]Su) can be used to demonstrate peptic ulcer disease in man and animals. We evaluated the usefulness of [99mTc]Su for detecting various grades of esophagitis. [99mTc]Su adhered to the distal esophagus for up to 3 hr in five of six patients with esophageal ulcers but adhered to only two of nine with lesser degrees of esophagitis. No adherence was seen in five patients without esophagitis. Thus, [99mTc]Su may not be useful for detecting any but the most severe grade of esophagitis. Based on these results, we speculate that the previously documented beneficial effects of sucralfate on mild to moderate esophagitis may be due to other mechanisms besides adherence to the ulcerated mucosa.

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A case of non-Hodgkin's lymphoma of the abdomen studied by gallium SPECT imaging is reported. The tomographic slices accurately demonstrated the location of residual disease after chemotherapy in the region of the transverse mesocolon. Previous transmission CT had shown considerable persistent retroperitoneal lymphadenopathy, but was not helpful in determining the presence of viable lymphoma.

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A rare case of extensive dermal uptake of Tc-99m MDP associated with renal failure is reported. The mechanism of Tc-99m MDP uptake in such examples of metastatic calcification is not proved, but may relate to adsorption onto hydroxyapatite crystals. This phenomenon is useful in demonstrating distribution of nonvisceral metastatic calcification.

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The deoxyribonucleic acid (DNA) of 36 isolates of Caryophanon latum and 3 isolates designated Caryophanon tenue, obtained from geographically diverse regions, has been examined for guanine plus cytosine (mol % G+C) base composition, genome size, and for relative reassociation levels. The isolates were found to be homogenous and group-specific in their base composition, with C. latum DNA ranging from 44.0 to 45.6 mol % G+C, and C. tenue from 41.2 to 41.6 mol % G+C. Genome size determined for representative isolates confirmed the distinction of the two groups. The genome size ranged from 1100 to 1200 X 10(6) daltons for C. latum and from 900 to 1000 X 10(6) daltons for C. tenue. DNA:DNA hybridization studies revealed relative reassociation levels as follows: C. latum to C. latum, 78-94%, C. tenue to C. tenue, 82-94%; and C. latum to C. tenue, 13-30%. Finally, based on genome size and mol % G+C similarities, DNA:DNA hybridization experiments between two strains of Lactobacillus and C. latum and C. tenue were performed. These experiments revealed essentially no polynucleotide sequence similarity between the Lactobacillus and Caryophanon isolates used.

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