RESUMEN
The aim of this study was to investigate the seasonal variation and hypertensive disorders of pregnancy in eastern Sudan, in the period between January 2008 and December 2010. The medical files of women attending at Kassala hospital, eastern Sudan with hypertension, with or without proteinuria were retrospectively retrieved. The data of patients with hypertensive disorders of pregnancy were compared with a similar number of controls that were normotensive and non-proteinuric. During the study period, there were 9,578 deliveries; 153 patients had hypertensive disorders of pregnancy, yielding an incidence rate of 1.6%. Of all cases and controls (306), there were 183 (59.8%) deliveries in winter, 84 (27.5%) in summer and 39 (12.7%) in autumn. The highest rate of pre-eclampsia was in winter (1.1%) (CI = 1.1-2.7, OR = 1.7, p = 0.004) and the lowest rate was in autumn (0.2%) (CI = 0.4-1.8, OR = 0.8, p = 0.758.). Our study revealed significant association between the incidence of hypertensive disorders of pregnancy and the winter season (103 (67.3%) vs 80 (52.3%), p = 0.001). Thus, more attention in the winter season might reduce the morbidity and mortality of hypertensive disorders of pregnancy.
Asunto(s)
Hipertensión Inducida en el Embarazo/epidemiología , Estaciones del Año , Adulto , Estudios de Casos y Controles , Femenino , Humanos , Incidencia , Preeclampsia/epidemiología , Embarazo , Proteinuria/epidemiología , Estudios Retrospectivos , Sudán/epidemiología , Adulto JovenRESUMEN
SUMMARY: Anaemia affects almost two-thirds of pregnant women in developing countries; it is associated with poor maternal and perinatal outcomes. Anaemia during pregnancy, through many endocrine alterations might influence maternal and fetal environment. This study was conducted to investigate the anthropometric, biochemical and hormonal profiles in paired maternal and cord blood samples and to compare these between anaemic (n = 68) [haemoglobin <11 g/dl] and non-anaemic groups (n = 57). A case-control study was conducted in Gadarif Hospital, eastern Sudan. Sociodemographic characteristics were gathered using questionnaires. Biochemical and hormones profiles were measured using appropriate laboratory methods. There was no significant difference in maternal and fetal anthropometrics parameters between anaemic (<11 g/dl) and non-anaemic groups. Maternal prolactin, cord serum albumin and cord serum ferritin were significantly higher in the anaemic group. No significant difference was observed in the other maternal and fetal parameters (total protein, growth hormone, cortisol, insulin, thyroid stimulating hormone, total thyroxine and triodiothyroxine). Thus, in this study there were some maternal and fetal endocrine modulations due to anaemia during pregnancy and further studies are needed.
Asunto(s)
Anemia/sangre , Complicaciones Hematológicas del Embarazo/sangre , Prolactina/sangre , Albúmina Sérica/metabolismo , Adulto , Estudios de Casos y Controles , Femenino , Ferritinas/sangre , Sangre Fetal , Hormona de Crecimiento Humana/sangre , Humanos , Hidrocortisona/sangre , Recién Nacido , Insulina/sangre , Embarazo , Sudán , Hormonas Tiroideas/sangre , Adulto JovenRESUMEN
This study aimed to investigate the incidence of eclampsia and its maternal and perinatal outcome in the Hospital of Obstetrics and Gynecology at Gadarif, Sudan from March 2007 to April 2009. There were 45 cases of eclampsia in 8,894 deliveries (5/1,000). Some 62% of first convulsions occurred antepartum, 15.5% occurred intrapartum, and the rest (11.1%) occurred postpartum. Ten patients died and there were 16 (35.5%) perinatal deaths; eight of these were stillbirths and eight were early neonatal deaths.
Asunto(s)
Preeclampsia/mortalidad , Adulto , Femenino , Humanos , Incidencia , Embarazo , Resultado del Embarazo , Estudios Retrospectivos , Sudán/epidemiología , Adulto JovenRESUMEN
Between June 2006 and October 2008, the safety of artemisinins during early human pregnancy was assessed in central-eastern Sudan. Pregnant women in the first or second trimester who were attending antenatal-care clinics at the Wad Medani, Gadarif and New Halfa hospitals were interviewed. Each was asked if they had had malaria in the first trimester of the index pregnancy and, if so, what treatment they had received. The women who had received artemisinins were then followed-up until delivery and their babies were followed-up until they were 1-year-olds. Overall, 62 of the pregnant women reported receiving artemisinins - artemether injections (48), artesunate plus sulfadoxine-pyrimethamine (11) or artemether plus lumefantrine (three) - during the first trimester. Medical records were available for 51 (82%) of these 62 women, and, in each case, these records showed the reported treatment and that malaria had been confirmed. Only nine (15%) of the 62 women given artemisinins had not known that they were pregnant when treated. Two of the treated women (both given artemether injections in the first trimester) had miscarriages, one at 20 weeks of gestation and the other at 22 weeks, each while receiving quinine infusions for a second attack of malaria. The other 60 women who had received artemisinins delivered apparently healthy babies at full term. No congenital malformations were detected, there was no preterm labour, no maternal deaths were recorded during the follow-up, and none of the babies died during their first year of life. It therefore appears that artemisinins may be safe to use during early pregnancy, although further study is clearly needed.
Asunto(s)
Antimaláricos/efectos adversos , Artemisininas/efectos adversos , Malaria/tratamiento farmacológico , Complicaciones Parasitarias del Embarazo/tratamiento farmacológico , Adolescente , Adulto , Peso al Nacer , Femenino , Humanos , Embarazo , Resultado del Embarazo , Primer Trimestre del Embarazo , Segundo Trimestre del Embarazo , Medición de Riesgo , Sudán , Resultado del Tratamiento , Adulto JovenRESUMEN
A thirty-five-year-old Sudanese woman (gravida 4, para 3), at 34 weeks gestational age, presented with snakebite in her right leg. Examination of the cardiovascular, respiratory, gastrointestinal, and central nervous systems revealed no abnormalities. Her blood urea was 58 mg/dl; creatinine, 2.6 mg/dl; whole blood clotting time, 5:35 minutes. The patient was diagnosed as having acute renal failure and was then managed conservatively. She received polyvalent antivenom serum intravenously. On the next day, she delivered prematurely and the baby passed away due to respiratory distress. There was no postpartum bleeding and the patient's clotting time was 5:30 minutes. She was discharged from the hospital after 7 days when her clinical, biochemical and hematological parameters returned to normal values without dialysis.(AU)