RESUMEN
Two children with idiopathic pulmonary haemosiderosis are reported. These are the first cases of this disease from Saudi Arabia and highlight the diagnostic problem caused by their presentation as cases of iron deficiency anaemia. The aetiopathogenesis, clinical presentation, diagnosis and management are discussed. The attention of paediatricians is drawn to this relatively rare cause of iron deficiency anaemia.
Asunto(s)
Hemosiderosis/diagnóstico , Enfermedades Pulmonares/diagnóstico , Anemia/diagnóstico , Biopsia , Niño , Preescolar , Diagnóstico Diferencial , Hemosiderosis/tratamiento farmacológico , Humanos , Enfermedades Pulmonares/tratamiento farmacológico , Masculino , Arabia SauditaRESUMEN
This prospective study analyzes the clinical features and histopathological findings in liver biopsies of pediatric patients presenting to the hospital with liver disease during a 10 year period. Only those patients in whom liver biopsy was performed for a tissue diagnosis were included. Fifty patients were investigated, all below the age of 12 years, of whom 36 were male and 14 female. Thirty-two were of neonatal-infantile group, 11 had a diagnosis of neonatal giant cell he hepatitis of infections origin and an intact biliary tree. Two had septic shock and one had leishmaniasis. The remaining 18 patients of the neonatal-infantile group constituted five case of glycogen storage disease, six of infantile obstructive cholangiopathy (biliary atreasia), four of fatty change and one each of congenital hepatic fibrosis, neuroblastoma and nonspecific reactive hepatitis. The eighteen older children had the following diagnoses: thalassemia in five, sickle cell disease in four, two each of Reye syndrome and hepatoblastoma. The remaining were one each of glycogen storage disease, Rotor syndrome, cirrhosis, fatty change and non-Hodgkin lymphoma (NHL). These findings are presented and discussed.
RESUMEN
Hemoglobinopathies are a major public health problem in Saudi Arabia. We studied the effect of splenectomy in 16 Saudi Arabian children with compound hemoglobinopathies. Seven patients no longer require regular blood transfusions, and transfusion requirements were decreased by 30 to 60% in the other eight patients. Three patients whose heights and weights were below the 5th percentile before splenectomy reached the 25th percentile 1 year after the surgery. In spite of preoperative pneumococcal vaccination and the penicillin prophylaxis after the surgery, one patient died of Haemophilus influenzae Group B bacteremia, and three others had six episodes of pneumonia.
Asunto(s)
Hemoglobinopatías/cirugía , Esplenectomía , Anemia de Células Falciformes/complicaciones , Anemia de Células Falciformes/cirugía , Niño , Susceptibilidad a Enfermedades , Hemoglobinopatías/complicaciones , Hemoglobinopatías/epidemiología , Hemoglobinopatías/genética , Heterocigoto , Humanos , Lactante , Estudios Retrospectivos , Arabia Saudita/epidemiología , Esplenectomía/efectos adversos , Talasemia/complicaciones , Talasemia/cirugía , Trombocitosis/etiologíaRESUMEN
Thirty-three children with leukemia who had neutropenia and fever were randomized to receive cefataxim and amikacin, versus the same antibiotics plus intravenous gammaglobulin (i.v. IgG). Duration of neutropenia, hospitalization and the interruption of chemotherapy were not different in the two groups; however, duration of fever was significantly shorter in the i.v. IgG group.