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Objectives: To evaluate the rate of use of antiplatelet pretreatment in patients with non-ST elevated acute coronary syndrome (NSTEACS) and its association with adverse events in two Argentine registries. Materials and methods: We retrospectively analyzed two Argentine acute coronary syndrome (ACS) registries from 2017 and 2022. We explored the incidence of pretreatment and the drug used. We evaluated the relationship between this strategy and a composite clinical outcome of in-hospital events: death + myocardial infarction + stent thrombosis + post-MI angina + transient ischemic event/cerebrovascular event, and with bleeding events (BARC 2 or higher). Subsequently, we performed a multivariate analysis by logistic regression with other clinical variables. Results: A total of 1297 patients were included; 75.6% were men, 25.6% diabetics, 27.1% smokers, 70.3% hypertensive, and 23.1% had a previous ACS. The mean age was 55.3 years. The mean GRACE score was 113.5, and the CRUSADE was 23.8. 44% of the patients received pretreatment, the majority with clopidogrel (93.5%). Pretreatment was significantly associated with a higher incidence of the composite clinical outcome (10.1% vs. 6.9%) (OR 1,56; IC 95%: 1,06-2,3; p=0,02). Bleeding events were numerically more frequent with pretreatment (8.7% vs. 5.9%) (OR 1,51; IC95%: 0,99 -2,3; p=0,054). In the multivariate analysis, pretreatment was no longer associated with a higher incidence of ischemic outcomes (OR 1,4; IC95%: 0,89-2,3; p=0,13). Conclusion: Pretreatment was used in almost half of the patients, mainly with clopidogrel, and did not show a reduction in ischemic events in patients with NSTACS.

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RESUMEN Introducción. La endocarditis infecciosa (EI) es una enfermedad potencialmente mortal que puede requerir tratamiento quirúrgico. A pesar de ser fundamentales en la toma de decisiones, los puntajes de riesgo quirúrgico no fueron generados específicamente para estratificar el riesgo de esta enfermedad. Objetivos. Evaluar la capacidad predictiva de los puntajes de riesgo quirúrgico ajustados a la EI. Material y métodos. Estudio unicéntrico observacional y retrospectivo de 270 pacientes mayores de 18 años que cursaron internación por EI en actividad desde 06/2008 hasta 02/2023, de los cuales 70 (26 %) fueron sometidos a cirugía cardíaca central. Se excluyeron las endocarditis asociadas a dispositivos, y los pacientes que no se sometieron a cirugía cardíaca. Los puntajes de riesgo quirúrgico analizados fueron: EuroSCORE II, EURO-IE, STS-IE y PALSUSE (Prótesis, Edad >70, (Large) gran destrucción, Staphylococcus, Urgencia, Sexo femenino, EuroSCORE >10). La capacidad predictiva de cada puntaje se evaluó por medio del estadístico C, calculando el área bajo la curva de la relación sensibilidad/1-especificidad, con sus respectivos intervalos de confianza (IC) 95%, y su significación estadística. Resultados. La mediana (rango intercuartílico, RIC) de edad fue de 60 años (48-67) y la de los días de internación fue de 23 (17-39). Cuarenta y un pacientes (58,57 %) tenían una válvula protésica. Respecto a los gérmenes causales, el Staphylococcus fue responsable del 30 % de las infecciones. Las principales indicaciones de tratamiento quirúrgico fueron la insuficiencia cardíaca (44 %), el absceso (19%) y la disfunción protésica (12 %). Se objetivó absceso anular en el 28,57 % de los pacientes. La necesidad de cirugía de urgencia fue del 45,71 % y de emergencia del 7,14 %. La mortalidad hospitalaria fue del 21,42 %. La capacidad predictiva de todos los puntajes fue estadísticamente significativa, excepto el STS- IE . El STS-IE presentó un área bajo la curva (ABC) de 0,586 (IC 95% 0,429-0,743). El EuroSCORE II, un ABC de 0,685 (IC 95 % 0,541-0,830); el EURO-IE presentó un ABC de 0,695 (IC 95 % 0,556-0,834) y el PALSUSE un ABC de 0,819 (IC 95% 0,697-0,941). Conclusión. Los resultados de este estudio sugieren que el score PALSUSE fue mejor predictor de riesgo quirúrgico en pacientes con EI activa, en comparación con los puntajes Euroscore II, EURO-IE y STS-IE.

ABSTRACT Background. Infective endocarditis (IE) is a life-threatening disease that may require surgical treatment. Despite being fundamental in decision making, surgical scores were not generated specifically to stratify the risk of this disease. Objectives. The objective of this study was to: To evaluate the predictive capacity of surgical risk scores adjusted for IE. Methods. Single-center observational and retrospective study of 270 patients > 18 years, hospitalized for active IE from 06/2008 to 02/2023, of which 70 (26 %) underwent central cardiac surgery. Device-associated endocarditis and patients who did not undergo cardiac surgery were excluded. The surgical risk scores analyzed were: EuroSCORE II, EURO-IE, STS-IE and PALSUSE (Prosthesis, Age >70, large cardiac destruction, Staphylococcus, Urgency, Female gender, EuroScore >10). The predictive capacity of each score was evaluated using the C statistic, calculating the area under the curve of the sensitivity/1- specificity relationship with their respective 95 % confidence intervals (CI), and statistical significance. Results. The median age (interquartile range, IQR) was 60 years (48-67) and the number of days of hospitalization were 23 (17-39). Forty-one patients (58.57 %) had a prosthetic valve. Regarding the causative germs, Staphylococcus was responsible for 30 % of the infections. The main indications for surgical treatment were heart failure (44%), abscess (19 %) and prosthetic dysfunction (12%). Annular abscess was observed in 28.57 % of patients. Urgent surgery was performed in 45.71 % and emergency surgery was performed in 7.14 %. Hospital mortality was 21.42 %. The predictive capacity of all scores was statistically significant, except for the STS-IE. The STS-IE score presented an area under the curve (AUC) of 0.586 (95 % CI 0.429-0.743). The EuroSCORE II, an AUC of 0.685 (95 % CI 0.541-0.830); the EURO-IE presented an AUC of 0.695 (95 % CI 0.556-0.834) and the PALSUSE an AUC of 0.819 (95 % CI 0.697-0.941). Conclusion. The results of this study suggest that the PALSUSE score was a better predictor of surgical risk in patients with active IE, compared to the Euroscore II, EURO-IE and STS-IE scores.