RESUMEN
We investigated stool specimens of 400 patients at Jordan University Hospital (300 patients with clinical diarrhoea and 100 controls without diarrhoea) for the presence of Clostridium difficile or its toxin. We found a 9.7% prevalence rate of C. difficile or its toxin in stools of patients with diarrhoea. The prevalence of other potential enteric pathogens, such as Salmonella spp. (2.3%), Shigella spp. (1.0%) and Entamoeba histolytica (2.7%), was significantly less. Prevalence of C. difficile or its toxin in controls was 3.0%. Toxin A was detected in 93.1% of C. difficile-associated diarrhoea cases using an enzyme immunoassay. Our study indicates that C. difficile-associated diarrhoea is mostly observed among hospitalized patients aged > or = 50 years, in association with antimicrobial treatment.
Asunto(s)
Clostridioides difficile , Infecciones por Clostridium/etiología , Infección Hospitalaria/etiología , Diarrea/etiología , Adolescente , Adulto , Distribución por Edad , Antibacterianos/efectos adversos , Toxinas Botulínicas Tipo A/análisis , Estudios de Casos y Controles , Niño , Preescolar , Infecciones por Clostridium/diagnóstico , Infecciones por Clostridium/epidemiología , Infección Hospitalaria/diagnóstico , Infección Hospitalaria/epidemiología , Países en Desarrollo , Diarrea/diagnóstico , Diarrea/epidemiología , Utilización de Medicamentos , Heces/química , Heces/microbiología , Femenino , Humanos , Técnicas para Inmunoenzimas , Control de Infecciones , Jordania/epidemiología , Tiempo de Internación/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Prevalencia , Factores de RiesgoRESUMEN
We investigated stool specimens of 400 patients at Jordan University Hospital [300 patients with clinical diarrhoea and 100 controls without diarrhoea] for the presence of Clostridium difficile or its toxin. We found a 9.7% prevalence rate of C. difficile or its toxin in stools of patients with diarrhoea. The prevalence of other potential enteric pathogens, such as Salmonella spp. [2.3%], Shigella spp. [1.0%] and Entamoeba histolytica [2.7%], was significantly less. Prevalence of C. difficile or its toxin in controls was 3.0%. Toxin A was detected in 93.1% of C. difficile-associated diarrhoea cases using an enzyme immunoassay. Our study indicates that C. difficile-associated diarrhoea is mostly observed among hospitalized patients aged > or = 50 years, in association with antimicrobial treatment