RESUMEN

Research on ZnO nanoparticles (NPs) has broad medical applications. However, the green synthesis of ZnO NPs involves a wide range of properties requiring optimization. ZnO NPs show toxicity at lower doses. This toxicity is a function of NP properties and pharmacokinetics. Moreover, NP toxicity and pharmacokinetics are affected by the species type and age of the animals tested. Physiologically based pharmacokinetic (PBPK) modeling offers a mechanistic platform to scrutinize the colligative effect of the interplay between these factors, which reduces the need for in vivo studies. This review provides a guide to choosing green synthesis conditions that result in minimal toxicity using a mechanistic tool, namely PBPK modeling.

Asunto(s)

Nanopartículas del Metal , Nanopartículas , Óxido de Zinc , Animales , Óxido de Zinc/toxicidad , Óxido de Zinc/farmacocinética , Toxicocinética , Nanopartículas/toxicidad , Nanopartículas del Metal/toxicidad