RESUMEN

Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric volume were only observed at the highest dose of the drug. In another set of experiments, when 50% alcohol (v/v) was administered to the pyloric-ligated rats pretreated with amitriptyline, it was observed that the drug significantly reduced the pH, total acidity and protein content.

Asunto(s)

Amitriptilina/uso terapéutico , Antidepresivos/uso terapéutico , Antagonistas Muscarínicos/uso terapéutico , Úlcera Gástrica/prevención & control , Amitriptilina/farmacología , Animales , Antiinflamatorios no Esteroideos/efectos adversos , Antidepresivos/farmacología , Aspirina/efectos adversos , Frío/efectos adversos , Etanol/efectos adversos , Ácido Gástrico/metabolismo , Técnicas In Vitro , Indometacina/efectos adversos , Masculino , Modelos Biológicos , Antagonistas Muscarínicos/farmacología , Ratas , Úlcera Gástrica/etiología , Úlcera Gástrica/patología , Estrés Psicológico/complicaciones