RESUMEN

Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.

Asunto(s)

Antozoos/química , Antineoplásicos/aislamiento & purificación , Esteroides/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Humanos , Océano Índico , Células MCF-7 , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Sesquiterpenos/química , Sesquiterpenos/aislamiento & purificación , Esteroides/química

RESUMEN

Chemical investigation of the soft coral Lobophytum lobophytum collected from the Red Sea led to the isolation of a new compound gorgostan-5,25-dien-3ß-ol (1), and two known compounds gorgosterol (2), and alismol (3). Structures were elucidated by employing extensive NMR and HR-ESI-MS experiments.

Asunto(s)

Antozoos/química , Esteroides/química , Animales , Colesterol/análogos & derivados , Colesterol/aislamiento & purificación , Océano Índico , Espectroscopía de Resonancia Magnética , Estructura Molecular , Sesquiterpenos/aislamiento & purificación , Espectrometría de Masa por Ionización de Electrospray , Esteroides/aislamiento & purificación